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larp7

Gene
larp7
Protein
La-related protein 7
Organism
Xenopus tropicalis
Length
593 amino acids
Function
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Mass
68.069 kDa
Sequence
MTAIETDTPSNKVKEDESTDLRKDREKKKRSRVKQLLADIAKQVDFWFGDVNLHKDRFLREQIEKTRDGYIDISLLASFNKMKKITTDSKLIARAVKNSSVVEINLSGTKIRRRFPLGEKPQDVDSRTVYVELLPKNVTHSWIERVFGKYGMVVYVSIPRYKSTGDPKGFAFIEFETQEQAAKAIEVLNNPPEEAPRKAGMFPKTVKNKHLPPVEVTEHSITEGCGTEEKKKKKKKKSKARKDSVEKAEEDTKEQDMDIISEGVPKRRKTVSESSVPDVQEADKQTAKKEKKKKERAESFDQSEKVRQGKRKCSSSEEHDCSSAKQKKSDTKDLPQDEKPMVTQEVLQECKELSTEEEKDAVDKKEISVPKVKRKRKKKHKERHRVGEEVIPLRVLSKTEWLVLKAEYLTLQRASMASLKKSMSEMNHISEEEMQTQPSMQSFDIKNGKVETVKNEPLGPQFVCGVIGKITSSDPLQGRKYVKDAFSGVCEVVYVDMLEGDTECHVRFKSPEDAQTAVKTRSDLQGKHNWKLQILAGDNEQRYWQKILVDRQAKLNRPREKKRGTEKLIAKAEKMRLAKTQEASKHIRFSDGF
Protein
La-related protein 7: larp7

Gene
LARP7
Protein
La-related protein 7
Organism
Homo sapiens
Length
582 amino acids
Function
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Mass
66.899 kDa
Sequence
METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
Protein
La-related protein 7: LARP7

Gene
LARP7
Protein
La-related protein 7
Organism
Macaca fascicularis
Length
581 amino acids
Function
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Mass
66.637 kDa
Sequence
METESGNQKNVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNVQAKEENMDTTNTSISKMKRSRPTSEGSDIESTEPQKQSSKKKKKRDRVEASSLPEVRTGKRKRSSSEDAESLGPRSKVKKIIQKDIIKEPSEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDGGVPQKTGMKNEKTNSEECPTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEISKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
Protein
La-related protein 7: LARP7

Gene
Larp7
Protein
La-related protein 7
Organism
Rattus norvegicus
Length
571 amino acids
Function
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Mass
64.949 kDa
Sequence
METENQKTMEESTEKRKEEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALKSSSVVELDLEGTRIRRKKPLGERPKDEEERTVYVELLPKNVTHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPSLRVAEEKKKKKKKKGRIKKEESVQAKELVVDSSSSGVSKATKRPRTASEGSEAETPEAPKQPAKKKKKRDKVETGGLPESKAGKRERSSAEDEDCLPPRPKLKKRAQKDGGGPAASEVSKEHRDLEFCSTEEEKEPGDRKGDSLSKGKRKHKKKHKERHKMGEEVIPLRVLSKTEWMDLKKEYLALQKASMASLKKTISQIKLESEMETESKAPPGSGQQCSTQEKVSAQGPQFVTGVIVKILSEDPLPGRKQVKDILATISEVVYIDLLEGDTECHARFKTPEDAQAVMNAQTEIKKKHSWNLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASQHIRFSEYD
Protein
La-related protein 7: Larp7

Gene
Larp7
Protein
La-related protein 7
Organism
Mus musculus
Length
570 amino acids
Function
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Mass
64.802 kDa
Sequence
METENQKTMEESTKRKEEKKKRSRVKQVLADIAKQVDFWFGDANLHKDKFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALKSSSVVELDLEGTRIRRKKPLGERPKDEEERTVYVELLPKNVTHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPSLRVAEEKKKKKKKKGRIKKEESVQAKESAVDSSSSGVCKATKRPRTASEGSEAETPEAPKQPAKKKKKRDKVEASSLPEARAGKRERCSAEDEDCLPPRPKAKKRAQKDGVGQAASEVSKESRDLEFCSTEEEKETDRKGDSLSKVKRKHKKKHKERHKMGEEVIPLRVLSKTEWMDLKKEYLALQKASMASLKKTISQIKLESEMETDCKAPTAGSGQECSTQEKVSAQGPQFVTGVIVKIVSGEPLPGRKQVKDILATISEVVYIDLLEGDTECHARFKTPEDAQAVMNAQTEIRKKHSWNLEVLSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASQHIRFSEYD
Protein
La-related protein 7: Larp7

Gene
larp7
Protein
La-related protein 7
Organism
Danio rerio
Length
555 amino acids
Function
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Mass
64.063 kDa
Sequence
MKVCQRKTIDTEKMSSVGDTACADLSEKKDNEKKKRSRVKQLLSDVKKQVEFWFGDVNLHKDRFMKSIIEQSRDGYIDIAVLTTFNRMKNLTADVKLIARALKNSTIVEVNDEGTRIRRKEPLGETPKDVDSRTVYVELLPKTVTHIWLERVFSKCGHVVYISIPRYKSTRHSKGFAFVEFETQEQAQKAVEMLNNPPEDAPRKPGIFPKTCRKKAVPFDAVTQDNDEDGKKKKTELKNSTSEETGSNNMDQDGMLESTVTSEPNLATLTSTVSKKAKKKRLRSQSFEASSGEDQFEMSSKMRKVEEEKSELKDLSSENKDEELNSLKKKDDSVLKAKRKRKKKLKERLKVGEEVIPLRVLSKKEWLDLKQEYLTLQKRCMAHLKQSVFQINQKPTNYHIVKLKEDDTNAFYKDTPKKELTSGPEFLSGVIVKISYNQPLPSKRCIKDMLSELSPVAYVDLLDGDTEGHVRFKSSEDAQKVIKARFEFQKKYNWNLELLSGDHERRYWQKILVDRQAKLNTPREKKRGTEKLISKAEKIIIAKAKEASNHIRFDD
Protein
La-related protein 7: larp7