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large2-a

Gene
large2-a
Protein
LARGE xylosyl- and glucuronyltransferase 2-A
Organism
Xenopus laevis
Length
723 amino acids
Function
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Has a higher activity toward alpha-dystroglycan than LARGE.
Similarity
In the N-terminal section; belongs to the glycosyltransferase 8 family.
Mass
83.148 kDa
Sequence
MLFSCRSKAKLLALTLLLLSAATWLYLSVGETEYGQSLGPVAPRFSATPSFQMELEIRLREAKEENRRLRQQLGEVRNEEQSTGGGTEGDNSSHCEHRSLTEKCELIHVAIVCAGHNSSRDVVTLVKSILFHRRNPLHLHLITDDVALRVLGNLFNTWMVPSLQISFYNASELKPDVAWIPNKHYSGIYGLLKLTLTKALPSDLSKVIVLDTDITFATDIAELWAIFKKFTGEQVLGLVENQSDWYLGNLWKNHKPWPALGRGFNTGVILLLLDKLRLIGWEEMWRLTAERELMNMLSTSLADQDIFNAVIKSSPTLVYQLPCYWNVQLSDHTRSEQCYSELADLKVIHWNSPHKLRVKNKHVELFRTLYLTFLEYDGSLLRRELIGCPSEGEQQGGSQATLSQLDEEDPCYDFRRESVASHRVHLSFLPHLTPPPDPYDVTLVAQLSMDRLQMLELICRHWEGPMSLALYLSDAEAQQFLRYAQASEVLQSRTNIGYHVVYKEGQLYPVNLLRNVALKNSHTPYVFLSDIDFLPMYGLYEYLRKSIAQQDPAGSPRALIVPAFETLRYRLSFPKSKADLLSMLDTGALYTFRYHVWEKGHAPTDYAKWRTATTPYRVEWAPDFEPYVVVRRDCPEYDQRFLGFGWNKVSHIMELDAQEYELVVLPNAFIVHMPHAPSFDISKFRSSENYRLCVQALKEEFHQDLSRRYGSAALKYLTAERNR