l(2)gl

Protein lethal(2) giant larvae

1166 amino acids

Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk (By similarity). Could act as a tumor suppressor.

Belongs to the WD repeat L(2)GL family.

127.028 kDa

MLKFIRGKGQQPTAERQRLQKDLFAYRKTAQHGFPHKPSALAYDPVAKLMAIGTQTGAIKVFGQPGVELYAQHTLVNNSAAELNVQLLEWVYGTGRILSLTAANQLILWEPVGTTLVPIKTLPFDGKLKKVSSLCCSLNKDLLWIGTEGGNIYQLDLKSFTIREPVIYHDVVLEQVPPTYKLNPGAIESIRQLPNSLNKLLIAYNRGLCVLWDMQTSAVERAYIAPGHGQSVGLSVNSTGTEFSWYHADGSYATWSIDNGEPPQNVNYVPYGPDPCKSINRLYKGQRGTNDVIVFSGGMPRSAYGDHNCVSVHVSDGHKVCLDFTSKVIDFFVTYKEGSDDVEVLIVLLEEELCAYDLTDPSILSIKAPYLHSVHASAVTCNYLASQVTQGVYERILRAGDEQDIDYSSIDWPITGGVLTDDSVESDEDEVVKDYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTASIFGNEHEYREDGAADISAEQLDEGEPPFRKAGLFDPYSDDPRLAVKKIAFCPKTGQLVVGGTAGQIVIADFDTAAEDQSSLKYNSMNLVSDRDGFVWKGHDQLNVRANLLEDNAVPLTENGVNITGVLQVLPPASITCMALEANWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGRSTRNNPTNQVPTTLEARPVERQIEARCTDDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTAATTVPPASGNVPPQASRRISAQLAKEIQLKHRAPVVGISIFDQTGSPVDQFNAGENGSPPHRLLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPELLQSLHSGSPTKSVRSHGEGDGAGNVSATSAAGRGDLYHEMALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGISSLCFTNDGEALYMMSSSELQRIALSTSKVVQPTGIVEVEPLESEDNETASLVNDGNESDKDGEANKELANTASDTQPPVATLRAKPLELNADRSSLHLTNGISNSNSPNRANETITSSIGDITVDSVRDHLNTTTTTLCSTTTEETVGRLSVLSTQTNQATTTVNMKDIPDINIPNLMDLASKSNTTETSTSSVVIKSVITSISHEKTNGESENVTTKTTAHEESQF

l(2)gl

Lethal(2) giant larvae protein

1161 amino acids

Isoform p127: Has an accessory function in control of cell proliferation and differentiation during development.

Belongs to the WD repeat L(2)GL family.

126.892 kDa

MLKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSYATWSIDNPEPPSNVNYVPYGPDPCKSINRLYKGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTFENNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPLENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPNQANETISSSIGDITVDSVRDHLNMTTTTLCSINTEETIGRLSVLSTQTNKASTTVNMSEIPNINISNLEDLESKRNTTETSTSSVVIKSIITNISHEKTNGDNKIGTPKTAPEESQF