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ku3

Gene
ku3
Protein
Non-homologous end joining protein Ku 3
Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Length
263 amino acids
Function
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.
Similarity
Belongs to the prokaryotic Ku family.
Mass
29.616 kDa
Sequence
MECCRFGLVSVPVQLFTAVERHTIRFHQVQRGTGDRVRQKRVNERTGQEVPFEEVVKGYPTEDGWVIVDPKELEDIAPGRSRTLEIVGFVDLDEIAPVYFRDTYYLAPSGPQYTKVYGLLREALATANRAGIATFVMRNRQYLAALKAEHEVLAVYLLHWADEVRDPHRELGASLPDHSGASEQELRMAVQLIEAMAIDWDPADYHDTYQQQVQALIDAKRAGGTLEPGIPPPRETEAVDLMQALRASVEHARAGRSGDRDTH