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korA

Gene
korA
Protein
2-oxoglutarate oxidoreductase subunit KorA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
653 amino acids
Function
Component of KG oxidoreductase (KOR) that catalyzes the CoA-dependent oxidative decarboxylation of 2-oxoglutarate (alpha-ketoglutarate, KG) to succinyl-CoA. Methyl viologen can act as electron acceptor in vitro; the physiologic electron acceptor is unknown. Is involved in the alternative TCA pathway that functions concurrently with fatty acid beta-oxidation. Since a growing body of evidence indicates that lipids (for example cholesterol and fatty acids) are a predominant growth substrate for M.tuberculosis during infection, flux through KOR likely represents an important step in intermediary metabolism in vivo. KOR-dependent decarboxylation of KG also appears to be an important source of CO(2) in M.tuberculosis metabolism.
Mass
69.182 kDa
Sequence
MDPNGSGAGPESHDAAFHAAPDRQRLENVVIRFAGDSGDGMQLTGDRFTSEAALFGNDLATQPNYPAEIRAPAGTLPGVSSFQIQIADYDILTAGDRPDVLVAMNPAALKANIGDLPLGGMVIVNSDEFTKRNLTKVGYVTNPLESGELSDYVVHTVAMTTLTLGAVEAIGASKKDGQRAKNMFALGLLSWMYGRELEHSEAFIREKFARKPEIAEANVLALKAGWNYGETTEAFGTTYEIPPATLPPGEYRQISGNTALAYGIVVAGQLAGLPVVLGSYPITPASDILHELSKHKNFNVVTFQAEDEIGGICAALGAAYGGALGVTSTSGPGISLKSEALGLGVMTELPLLVIDVQRGGPSTGLPTKTEQADLLQALYGRNGESPVAVLAPRSPADCFETALEAVRIAVSYHTPVILLSDGAIANGSEPWRIPDVNALPPIKHTFAKPGEPFQPYARDRETLARQFAIPGTPGLEHRIGGLEAANGSGDISYEPTNHDLMVRLRQAKIDGIHVPDLEVDDPTGDAELLLIGWGSSYGPIGEACRRARRRGTKVAHAHLRYLNPFPANLGEVLRRYPKVVAPELNLGQLAQVLRGKYLVDVQSVTKVKGVSFLADEIGRFIRAALAGRLAELEQDKTLVARLSAATAGAGANG

Gene
korA
Protein
2-oxoglutarate synthase subunit KorA
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
376 amino acids
Mass
41.377 kDa
Sequence
MTEEYFIQGNDACARGAIKAGCRFFAGYPITPSTEIAEEMALLLPREGGVFVQMEDEIGALGAVIGAVWSGVRGMTATSGPGFSLMQEHVGYAAMTETPLVIVNVQRGSPSTGQPTMASQSDMMQARWGSHGDYEIIALSPSSVQECFDFTVRAFNLAEEYRVPVMVMGDEIVGHMREKITIPDRVKIRKRRGPSVPPEEFLPFSAPEDGVPEMPAFGDGYRIPVTGLTHDEGGYPDASNPEGHHRLVKRLCDKILRHRDRISDVQEELTEDAYITVISYGAPSRSVATAVKMAREDGVRAGYLKINTPWPFPETEVRAAAERSGKLLVVEMNLGQMFYEVQRVAAGMAEVELLPKIGGEIHRPEEILNMILKMNR

Gene
korA
Protein
2-oxoglutarate synthase subunit KorA
Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)
Length
375 amino acids
Mass
40.974 kDa
Sequence
MTEEYFIQGNDACARGAISAGCRFFAGYPITPSTEIAEEMAVLLPGEGGVFVQMEDEIGALGAVIGAVWGGVKGMTATSGPGFSLMQEHVGYAAMTETPLVIVDVQRGSPSTGQPTMASQSDMMQARWGSHGDYEIIALSPSSVQECFDFTVRAFNLAEEYRVPVVVLSDEIVGHMREKITIPDKVEIRKRKSPTSPPGEFIPFKPQGDFVPEMPAFGDGYRVPVTGLTHDERGYPDASNPEGHEKLVKRLCDKILNHRDKIVDVQKGWTDDADITVISYGAPSRSVATAVKMARSEGVRAGYIKINTPWPFPETEIREAAESSRKLLVVEMNLGQMFYEVQRVASGMAEVELLPKIGGEIHRPDEILNKIMGMK

Gene
korA
Protein
2-oxoglutarate synthase subunit KorA
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
366 amino acids
Mass
41.06 kDa
Sequence
MKVEFMQGNQACAKGAIKAGCRFFAGYPITPSTEIAEAMARELPKVGGYYIQMEDEIGSIAAVIGASWGGLKAMTATSGPGFSLMQENIGFAYMTETPCVVVDIQRGGPSTGQPTMASQGDMMQCRWGSHGDYEVIALAPSSVQEMYDFTIMAFNYAEKYRIPVFVMADEIVGHMREKVILHDNIEIINRKKPEEKPCKKPYPFDKLIPEMPVFGEGYNVHITGLTHDERGYPDVSPETHDKLVRRIVNKIRKNKDEIIKWEGENLDAEIVFVCYGSPSRTVKHAVRNLREKGLDVGYIRLITVYPFPDDLLKKLKAKKVVVPEMNLGQIYYEVERVCKKAEEVILVDKIGGELHRPEELERAVLG

Gene
korA
Protein
2-oxoglutarate synthase subunit KorA
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
346 amino acids
Mass
37.506 kDa
Sequence
MEMELIQGNEAAVRGAINAGCNFFAGYPITPSSEIAHGMAELLPKFGGVFIQMEDEIASISAVIGASMAGAVAMTATSGPGFSLMQEGMGYAAITESPVVIFNVMRAGPSTGIPTAPSQGDAMQARYGSHGDYPIVVLAPASVKDMYYLTVEAFKIAFRFSTPVIVLSDEIVGHMRESVALPPLGEIESYEKRAKNLIDGRRRHRTGLVHTENGLPTTDLEEYEKLLRLLFAKFDDFRPMVRFEGEEGVLFVAYGSSYRLAKSSAKLLAEKGVSAGILKLESLFPFPEDAVRRYSKKADLVVVPEMNAGQVVKEVERVCCCRVKGVSYFGSLILPEKLVEIVEGEL

Gene
korA
Protein
Protein KorA
Organism
Streptomyces lividans
Length
241 amino acids
Function
Controls plasmid transfer and prevents the lethal effects of the tra/kilA gene. Repressor for the transcription of certain pIJ101 promoters, including those the from kilA and kilB loci.
Mass
25.318 kDa
Sequence
MSLERTPPYLQVVAALKAKIVSGELKHGDTLPSVRDLAAQYEISTATAQKVHRTLKAEGLAEAKQGSATTVSTRRTLHRTAADRLESALSTGRIYADGEYAVITSAALAEPPEWVADLLGTESGQAVRRERVTHSADDQPVSASVSWFSADLAETVPALLVRDRIIGGTPSAIEAATGRRAVATEEATTAAAATEDQAALLGVAAGAPVLLSRNVYVDAQGDTIEVGESVAPAGRWRVHRD