Function
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development.
Sequence
MEYHCVLFTVLLQLIIQPGRSRPTITPEGPRLTVPLYSNFSLHCQSNSTVRWQHENRPMRTLKEEQRQGQQTILKVNRAGPQHLGKYSCREEKTGEKSSIYVYVKDPENPFRRTIVFDIVAAEGDTTVIPCLATDPDMKNLNLQKCDGQPLPNSLRYSASLETGVSVEKVRKEFEGCYVCVGTLDAATVKSGRYQLTVRLVPDAPPPITLGQPQRVLLTQGEKLSLSCSTSNVNSDIAVKWKAPNGVNPSVHQNSHLLTEPITHVRTAILSLSSVTMQDAGNYSCEAINEKGTTAKPVWVNIYEKGFINITSVDNSTRRVRAGESLSLRVVMNAYPKPHTFSWSYSGVKLTNTTDHVITSRTHGNSYTSELKLVRLKVSESGIYTFSCLNRDATIRQTFEVHVISKPQIVSYEGPIDGQVRCVAEGYPTPQIKWYYCDLPHSRCSNLLNATQEEEDVVTVTMTNPPFGKGAVESRLNITKNNYATLECVASANGEIVYTLFSISENTVPHELFTPLLIGFVAAAVILVLILIVLTYKYMQKPKYQIQWKVIEGIHGNNYVYIDPTQLPYDHQWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTVMTVAVKMLKPSAHATEKEALMSELKVLSYLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYYTTLGEDAYYRNVMMQSEPNDSRNGYMTMKPSVLGILSSENRRSLNKGDSYSDSDAVSEILQEDGLTLDTEDLLSFSYQVAKGMDFLASKNCIHRDLAARNILLTQGRVAKICDFGLARDITTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMESPEFSPSEMYDIMHSCWDADPVKRPSFSKIVEKIEQQISDSTKHIYLNFSSRLPAAPGPREESSSHVHRLNSVGSHSTATQPLLSSNDVFLDRSSPSHPVV