Protein
Kinase D-interacting substrate of 220 kDa B
Function
Downstream target for both neurotrophin and ephrin receptors. May play a role in nerve growth factor (NGF)-induced recruitment of rapgef2 to late endosomes and neurite outgrowth.
Sequence
MDTTTSIKMTTLAIQNLFSYVEEENLAAVKVHLDKFKEVDGRSDNGQTPLMLASEQGSLEIVQELIRRGANVNLDDVDCWSALISAAKEGHVEVVKELLENSAYIEHRDMGGWTALTWASYKGRVEVATVLLENGANPNTTGQQYSVYPIIWAAGRGHAEIVKLLLEHGAKVNCSDKYGTTPLIWAARKGHYDCVMHLLENGADVDQEGANSMTALIVAVKGGYTEVVKELLKRNPNVNMTDKDGNTALMIAAKEGYTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLHKYADIDIRGQENKTALYWAVEKGNATMVRDILQCNPDTETTTKDSETPLIKATKMRSIEVVELLLDKGAKVSAVDKRGDTPLHIAIRGRSRRLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTESDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQVEPLFQFSWLVVLLSLLLCGSVALVLGFTVDPKLAIAISLSILALLYVFFVVVYFGSRREGESWNWAWVISTRLARHIGYLELLLKLMFVNPPELPEQTTRALPVRFLFTDYNRLSSVGGETSMAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCIPSFVIFLFILGCLIMGMALLAVFKVDGQNQTVNAVLVSMASVVGLALLLNCRTWWQVTDSVLNSQRKRLHSAANKMHKLKSEGFMKVLKNEVELMAKMAKTIDGFTQNQTRLVVIIDGLDSCEQDKVLQMLDTVRVLFSKGPFISIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSSAKKMCAPAPANGETGNSEGWHEELDRKLSQNSLGDQTKFGSKTTLNRRDTYRRRQMQRSVTRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLILYLEETDGIPDQTNLKTIYERISKNIPTTKDVEPLLEIDGDVRSFEVFLSSRTPVLAARDIRTFLPCTVNLDPKLREIIADVRAAREQVNMAGVTYPTLPLQEGRPISMYSQQSSACSPTASFNGPYNPPGVSPQPHSAYFSGMAGPQHPFYNRGSASVVSGTPSILLSSMSTDVICERVKLIDGIDQNLISQYTATIKKANINGRVLSQCNIDELKKEMNMNFGDWQLFRTSVLEMRHVENQVLHEEAPSEQGSITVGHVEPCRHAGAAAQGVAGNTDTSPMYNFNLSFEELSNVGLEEPPRHVNATWMGTTHRTPSMSSLNSQESSNEICKLTDKQQAEYRNAYEDYIASMSQLELGMEKPVPPFVSQLMHSSSEDKKKDGNDQDGRKSVSKRGSTKSGSDNTDYASADAATLDPITEEDEKVDHGSSKSLLGRKTSGDKVSLFQGADLKLKAGGGSRYQKLTSDDEESEESDNAPLLKDGKKPEAKASDGGDRSLTKGKDYLSDKKDSSDSGVRSNESSPNHSLQDEEADLSQSERANLIELDEENSARKRGLPNSLSGLQDPTIARMSICSEDQCSLLASSPEESWPSSKSYNLNRTPSNTTLNNNTNAQQGNHIRQPSDSSNTTSTTTGSDVIINPGTSTTSATTQNENVRVVHLKRGLNPGDPPEILKVSSETVTFGEERESIL