KDTA

Probable 3-deoxy-D-manno-octulosonic acid transferase, mitochondrial

447 amino acids

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses.

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily.

49.888 kDa

MKLGVFVYRLYRALTYGVSPLIHLHIRWRRLRGLEHFSRWPERFGHPSAVRPPGSLIWFHAVSLGEGMAAIPVIRHCNEVKSDLTILMTTTTVSAFEVIKNQLPVGVLHQFAPLDTPLAIDRFLGHWKPNAIIIMENELWPNLIMAASGLLIPLGLLNARMSTKSFKRWSSPLLLPLVSLLLSKFSLIAPLSTLQGIRFQLLHAPPFVINYSGDLKYVVNKFHVSSGTSESIRDLKVELAEMKVWIASSLHRGEEEVILGVHNMLLESHPDSVVIIVPRHPHHGQQIAHKLRKDGQSVALRSQNEKLTPRKTNIYVVDTLGELRELYSVAPIAVIGGSFIPGLTGHNLSEAAAAGCAVITGCHVGHFSHMVKAMQQANPLSVTQVSTKLELKEAVDLLLSNPEILETHQRASKDVYESLSSCIITNIWKLLNLHIFRGKSRNHIECK

kdtA

3-deoxy-D-manno-octulosonic acid transferase

353 amino acids

Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily.

40.676 kDa

MQFEVLKRFFPKESLKNCKGALWVHTASIGEFNTFLPILKELKREHRILLTYFSPRAREYLKTKSDFYDCLHPLPLDNPFSVKRFEELSKPKALIVVEREFWPSLIIFTKVPKILVNAYAKGSLIEKILSKKFDLIIMRTQEDVEKFKTFGAKRVFSCGNLKFICQKGKGIKLKGEFIVAGSIHTGEVEIILKAFKEIKKTYSSLKLILVPRHIENAKIFEKKARDFGFKTSFFENLEGDVILVDRFGILKELYPVGKIAIVGGTFVNIGGHNLLEPTCWGIPVIYGPYTHKVNDLKEFLEKEGAGFEVKNETELVTKLTELLSVKKEIKVEEKSREIKGCYLEKLREFLRGL