Protein
Lysine-specific demethylase 5B-B
Function
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity).
Similarity
Belongs to the JARID1 histone demethylase family.
Sequence
MTQQGPAEFTPPPECPVFEPSWEEFKDPFAFINKIRPIAEKTGICKVRPPPDWQPPFACDVDRLHFTPRIQRLNELEAQTRVKLNFLDQIAKFWDLQGCTLKIPHVERKILDLYQLNKLVADEGGFDLVCRERRWTKIAMTMGFAPGKAVGSHLRAHYERILYPYNLFQSGTNLLCLQKPGDEVNDIDKEYKPHDLLQRQNVPLQPSNTSAPARRAKRMKTESGCIKSEEGEGVENKPNLRRRMGSFVVKTEPKKEIPIQVKEEPVEIKELNPEPEKSKPKKKNIPPPPVSMVDLYVCLVCGKGNDEDRLLLCDGCDDSYHTFCLIPPLTDVPKGDWRCPKCLTQECCKPQEAFGFEQAHRDYTLKAFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVGTIQEDVTVEYGADIASKEFGSGFPIKGGRFKIAPHDEKYLQCGWNLNNMAMMTPSVLTHVTADICGMTLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGAPGFAAEQLEAVMKKLAPELFDSQPDLLHQLVTIMNPNTLMAHGVPIYRTNQCAGEFVITFPRSYHSGFNQGFNFAEAVNFCTVDWMPLGRQCVDHYRQLHRYCVFSHDEMVCNMAMKADCLDVVLASAVQKDMQLMIKEERELREKVRKMGVAQCELFQYDLLADDERQCVKCRTTCYLSALTCPCRPGVQVCLYHTHDLCSCPISNYTLNYRFTLDDLYPMMNAVRQRAEYYDDWASRVTEVMEAKLDKKRNVTVFRTLLEESNEQSFPENDLLRQLRLVTQDAEKCSSVAQQLLNGKRQTRYRTGKAKSPNQLTVEEMRSFVRQLYNLPCSLTQAPLLKELLNSIEDFQQHSEKLLSDEVSADAVSEIESLLEEGSQFDVFLPELPLLRERLEQARWLTGVHQAEDPVANPCGLSLESMRRLIDRGVGLTPHPSIERMMARLQELLTVSEELEENAQALLKARPPESLETLCSMLTQVEGVPAYLPNCLLLQDTVNRAKEWLQEAESLQVGGQVPVFSSLSDMVLRAHSIPVRLEPLDQLEVQVSEVQSWKETAAKTFLIKSSPFTLLEVLCPRWEMGSSLKKKKMRKMKGDCVSSGKKKFVKLDSMSDVERALSDSKDSASAMFTLAEVRLKELESLCSLRASNESKLLPTADCASLKVCVCQKPAMGAMLQCELCRDAFHSVCVRGPSDPLDPEAWLCPLCLRSTKPPLDKIRSLLSSLQRIRVRLPEGDALRYMIERSVSWQRRVREVIDSYGLSSTSQDGRGASPSQNLYRSTGHSRKLQLCGSPSRCQDWAVSGQEQTVFYTEQRCIPLQGLSPELEELMVEGLVLQVSLPETQQLYRLLLSGPPTTNTSHAEHKSYLTPPQTETDAITSAEKKAKRRMNRDEVDIRERGTKLKSKKQRMMGVEKRRERKAASVSASDMSQSEDSEEDMTLCPAESCLQPEGEEVDWVQCDCCNRWFHMICVGVSAELAAEEDYMCVSCSTSHMDRRK