kdm3a-b

Lysine-specific demethylase 3A-B

1334 amino acids

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).

Belongs to the JHDM2 histone demethylase family.

149.945 kDa

MVLTQQENLSVLVGQRFVCLLGKDLQVDPDTVSKWPWKSGIVRAASHKDLHCPEIKIFVEYDDESWENRTWLELYGPTVKMFLVEHNLVLADHASPSNPSVSVQCPAMVYKVLVGKFSLGSTACLQFLGEKDKVFLSKELVKPVRDRETLKQFMQDNKTFNKAFQELIRKSVDESRLLQAARNIISMPINVYSMDPSMQWFSGTITNVRTASRALEIKCEQLPSLKIIDPALLHVVLVHNYGDQNDKSKKPRASKRKSQDTESEDQTEVKQTRNEEVPSKDVTQKTSFLTYRRDDGKTLVVVDNPKATTNNLFNYMTPATEDQQKVQQSLSSKQSVPVGFGETLLGCAATTPGIQNAATPPPANSPPSFGAATPQGKGSQNLPGDTTVLNGDANREETNLFLSAAASQGNKRSMGFGIMESPSTFSSLSTMPSWSGQPNSENGLKSENLFAAFTKSSTVFPKGFEFSVKSFPEQKMLSVTDSPKTALQKTCVPQQEQNVIRKPENNHTSVKAIKPQEPPYTKSPNKTDGVTYPKSILLNPQKLKRLQQSGDCFVQDGSCNNIAPHLHKCRECRLDRFGRSREQRDSAVFCRFFHFRRLHFNKHGMLKEGGFLTPNKYDAEAINLWLPLASSVVDLDLDTAKYILANIGDHFCKLVMSEKEVMSSTDPSKQVAWKRAVRGVREMCDACDTTIFNLHWVCPKCGFGVCVDCYRMRKKSLSSGEEGNEMFSWLKCMKGQLHEPENLMPTQIVPGKALYDVCDIVHSVRGRWGIKSNCSCSNKHMRPVSKPVVKEEVKPSTPEPEPIKSLLAQPNVCTVPDPPAIPNKPPTPACSSPLSWLTNFPQTIVNKENKDNLFASTSKSEHKPLPSFASFGKPVSALQTFGSSILTPTTSNNSGFLRNLLNASTLKQETSDKSTPKILDDIFASLVQSRPLSDFDRKPQGLPIQPSLMGFNTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHNNLNSELWRPESFRREFGDQEADLVNCRTNDIITGATVGDFWDGFEDIPGRLKNDTGESMVLKLKDWPPGEDFRDTMLSRFEDLMNNIPLPEYTRREGKLNLAARLPTYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGEHDQDQEVLRTIQDGDADELTIKRFIEFKEKPGALWHIYAAKDTEKIRQFLKKVAEEEGHENPPDHDPIHDQSWYLDNILRKRLLQEHGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFCLTQEFRYLSHTHTNHEDKLQVKNVIYHAVKDSIAILKANESSLGKL