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kdm3a-a

Gene
kdm3a-a
Protein
Lysine-specific demethylase 3A-A
Organism
Xenopus laevis
Length
1331 amino acids
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
Similarity
Belongs to the JHDM2 histone demethylase family.
Mass
149.611 kDa
Sequence
MVLTQQENLSVLVGQRFTCLLGTDLQLDPDGVSKWPWKSGIVRAASHKDLHCPEIKIFVEFDDEAWEKRTWIELYGATVKMFLVEHNLVLADRVSPSNSVPVQCPAMVYKVLVGKFSLGTATCLQFLGDKDKLFLSKELVKPVRDRETLKQFMQENKTFNKAFQELIRKSVDESRLQQATRNIIGMPINVYSMDPSMQWFSATISNVRTASRALEIKCEQLPSLKIIDPALLHVVLVHNYGDLNDKSRKPRAPKRKSQDTESEDQTELKQTRNEEVPSKDVTQKTSFLTYRRDDGKTLVVVDNPKATNNLFNYINTTTEDQQKVQQQSLSSKQSVPVGFGEALLGCAATTPGILNAATPPQANSPPSFGAATPQGKGTQNLPGDTTLLNGEAKREETNLFLSAAASQGNKRSLGFGMMESPSTFSSLSSMPSWSGQPKSENGPKSENLFAAFTNSSTVFPKGFEFSVKSFPEQKMLSVTDSPKTAPPMTCVQQQEQKVVKKPENNHTSVRAIKPQEPPYPKSPNKNDGVTYPRSILLDPQKLKRLQQSGDCFVQDGSCNDIAPHLHKCRECRLDRFGRSREQRDSAVFCRFFHFRRLHFNKHGMLKEGGFLTPNKYDAEAINLWLPLASNVVDLDLDTAKYILANIGDHFCKLVMSEKEVMSATDPSKQVAWKRAVRGVREMCDACDTTIFNLHWVCPKCGFGVCVDCYRMKKKSLSSGEDGNETFSWLKCVKGQLHEPENLMPTQIVPGKALYDVGDIVHSVRGRWGIKSNCLCSNKHVRPVVKPVVKEEVKPSTPEPEPTKAPLAQPNVCTAPDPIAIPSTPPTPACSSPLSWLTNLSQTTVNKENKDNLFASNLEHKPLPSFASFGKPVSALQTFGSSILTPTTSNNSGFLRNLLNSSTLKQETNEKSTPKILDDIFASLVQSRPLSDFARKPQGLPIQPSLMGFNTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVIVSGIHNNLNSELWRPESFRREFGDQEADLVNCRTNDIITGATVGDFWEGFEDISARLKNDKGEAMVLKLKDWPPGEDFRDTMLSRFEDLMNNIPLPEYTRREGKLNLAARLPAYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDATNVMVYVGIPKGEHDQEQEVIRTIQDGDADELTIKRYIEFKEKPGALWHIFAAKDTEKIRQFLKKVAEEQGHENPPDHDPIHDQSWYLDNTLRKRLLQEHGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSHTHTNHEDKLQVKNVIYHAVKDSIAILKANEASLGKL