kce

3-keto-5-aminohexanoate cleavage enzyme

276 amino acids

Involved in the anaerobic fermentation of lysine. Catalyzes the reversible reaction between 3-keto-5-aminohexanoate (KAH) and acetyl-CoA to form 3-aminobutyryl-CoA and acetoacetate. The reaction involves the deprotonation of KAH, the nucleophilic addition onto acetyl-CoA and the intramolecular transfer of the CoA moiety.

Belongs to the KCE family.

30.222 kDa

MEPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPEIIIQISTGGAVGESFDKRLAPLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIITQNPLHIQFVLGVPGGMSGKPKNLMYMMEHLKEEIPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALNK

kce

3-keto-5-aminohexanoate cleavage enzyme

273 amino acids

Involved in the anaerobic fermentation of lysine. Catalyzes the reversible reaction between 3-keto-5-aminohexanoate (KAH) and acetyl-CoA to form 3-aminobutyryl-CoA and acetoacetate. The reaction involves the deprotonation of KAH, the nucleophilic addition onto acetyl-CoA and the intramolecular transfer of the CoA moiety.

Belongs to the KCE family.

29.685 kDa

MEKLIITAAICGAEVTKEHNPNVPYTVEEIVREAKSAYDAGASVIHLHVREDDGTPTQSKERFKMCVDAIKEACPDAIIQPSTGGAVGMTDEERLQPVFLKPEMASLDCGTCNFGGDEIFVNTENMIINFSKYMIKNGVKPECEVFDKSMIDMAIRLAKKGHIQTPMHFNFVMGVNGGISATPRDLVFLIGSIPSESSFTVSAMGRNQFPMAAMAIITGGHVRVGFEDNVYIEKGVPAKSNGELVEKVVRLAKEFGRPVATPSEAREILGISK

kce

3-keto-5-aminohexanoate cleavage enzyme

272 amino acids

Involved in the anaerobic fermentation of lysine. Catalyzes the reversible reaction between 3-keto-5-aminohexanoate (KAH) and acetyl-CoA to form 3-aminobutyryl-CoA and acetoacetate. The reaction involves the deprotonation of KAH, the nucleophilic addition onto acetyl-CoA and the intramolecular transfer of the CoA moiety. It can also use beta-alanyl-CoA as substrate.

Belongs to the KCE family.

30.137 kDa

MMEKLIITAAICGAEVTKEHNPAVPYTVEEIAREAESAYKAGASIIHLHVREDDGTPTQDKERFRKCIEAIREKCPDVIIQPSTGGAVGMTDLERLQPTELHPEMATLDCGTCNFGGDEIFVNTENTIKNFGKILIERGVKPEIEVFDKGMIDYAIRYQKQGFIQKPMHFDFVLGVQMSASARDLVFMSESIPEGSTWTVAGVGRHQFQMAALAIVMGGHVRVGFEDNVYIDKGILAKSNGELVERVVRLAKELGREIATPDEARQILSLKK