kanE

Alpha-D-kanosaminyltransferase

386 amino acids

Glycosyltransferase involved in the biosynthesis of kanamycins by catalyzing the transfer of the hexose kanosamine from UDP-alpha-D-kanosamine to disaccharide precursors. Can also use UDP-alpha-D-glucose as sugar donor with much lower efficiency.

Belongs to the glycosyltransferase group 1 family.

43.218 kDa

MHLLVRALVEEMAGRGVPHRVLTMSPPKVPKDIRIGQRIKVHARRLPVLPIPSDLEGYFGLVGAWAKGSLLWVLRNRKRLRREIGARVHAHCDGSGAAAFYPYLMSRILGVPLVVQIHSSRYLSQHPTTLFERVTDPIAKWAERHAVRKAAAVLMLTDRARDEMRRKAQLPAERVHRLAYLASDQFKDADTEARRAELRERYGLDDRPIVLYVGRIAAEKGVEYYIEAAAELTRRGRDCQFVIAGDGPARPDLEKLIGARGLRDRVTITGFMSHEFIPSMISLGELVVLPSRYEELGIVILECMTMRRPLVAHDVNGVNKLIEDGTTGIVVPPFRTPEMADAVERLLDDPELRERMAENAAPLPAAKYSLSAAGDQLAGIYREIGL

kanE

2-deoxy-scyllo-inosamine dehydrogenase

343 amino acids

Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(+) or NADP(+), forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).

Belongs to the zinc-containing alcohol dehydrogenase family. DOIA dehydrogenase subfamily.

35.936 kDa

MKALVFHSPEKATFEQRDVPTPRPGEALVHIAYNSICGSDLSLYRGVWHGFGYPVVPGHEWSGTVVEINGANGHDQSLVGKNVVGDLTCACGNCAACGRGTPVLCENLQELGFTKDGACAEYMTIPVDNLRPLPDALSLRSACQVEPLAVALNAVSIAGVAPGDRVAVMGAGGIGLMLMQVARHLGGEVTVVSEPVAERRAVAGQLGATELCSAEPGQLAELVARRPELTPDVVLEASGYPAALQEAIEVVRPGGRIGLIGYRVEETGPMSPQHIAVKALTLRGSLGPGGRFDDAVELLAKGDDIAVEPLLSHEFGLADYATALDLALSRTNGNVRSFFNLRD