kamB

Gene

kamB

Protein

16S rRNA (adenine(1408)-N(1))-methyltransferase

Organism

Streptoalloteichus hindustanus

Length

215 amino acids

Function

Specifically methylates the N(1) position of adenine 1408 in 16S rRNA. Confers resistance to various aminoglycosides (By similarity).

Similarity

Belongs to the methyltransferase superfamily. Kanamycin-apramycin resistance family.

Mass

23.67 kDa

Sequence

MRRVVGKRVLEFSEAEFDQLRSQYDEVVLDVGTGDGKHPYKVARQHPNQLVVALDADKTRMERMSAKAAAKPAKGGLPNLLYLWATAEKLPPLTGVGELHVLMPWGSLLRGILGSSPEMLRGLAAVCRPDAAFLVALNLHAWRPPVPEVGEHPEPTPETVDEGLAARYAQAGWQLTDCRYLAAEEVAALETSWTRRLNSSRDRFDVLALTGKINP

Protein

16S rRNA (adenine(1408)-N(1))-methyltransferase: kamB

Gene

kamB

Protein

16S rRNA (adenine(1408)-N(1))-methyltransferase

Organism

Streptoalloteichus tenebrarius (strain ATCC 17920 / DSM 40477 / NCIB 11028)

Length

215 amino acids

Function

Specifically methylates the N(1) position of adenine 1408 in 16S rRNA. Confers resistance to various aminoglycosides, including kanamycin, neomycin and apramycin.

Similarity

Belongs to the methyltransferase superfamily. Kanamycin-apramycin resistance family.

Mass

23.664 kDa

Sequence

MRRVVGKRVQEFSDAEFEQLRSQYDDVVLDVGTGDGKHPYKVARQNPSRLVVALDADKSRMEKISAKAAAKPAKGGLPNLLYLWATAERLPPLSGVGELHVLMPWGSLLRGVLGSSPEMLRGMAAVCRPGASFLVALNLHAWRPSVPEVGEHPEPTPDSADEWLAPRYAEAGWKLADCRYLEPEEVAGLETSWTRRLHSSRDRFDVLALTGTISP

Protein

16S rRNA (adenine(1408)-N(1))-methyltransferase: kamB