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jk0900

Gene
jk0900
Protein
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
Organism
Corynebacterium jeikeium (strain K411)
Length
167 amino acids
Function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
Similarity
Belongs to the class II aldolase/RraA-like family.
Mass
17.709 kDa
Sequence
MAEEKLTFIPTADLVDIIGSDVRSCDTQFRDLGGVVEFCGKITTVKCFQDNALLKSVLQEDNPGGVLVIDGDASMHTALVGDIIAGLGKDHGWAGVVINGPIRDSKVIGQMEFGCKALGTNPRKSTKTGEGERDVTVSFGGVDFIPGEYIYCDSDGIIVSDEIVQPV