jak1

Gene

jak1

Protein

Tyrosine-protein kinase JAK1

Organism

Cyprinus carpio

Length

1156 amino acids

Function

Tyrosine kinase of the non-receptor type.

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Mass

132.246 kDa

Sequence

MPELAVMELGRQLCGKMKKQRKAEMTVLTVMKGLEIHFYLPDTHQLEYFKDCHTAEDLCVEGCQEDATSHLCADNLFALSEESQDLWYAPNHAFKITEETSIKLHYRMRFYFTNWHAPVRTESPVWRHSLFKHKGVSVSPKGPEGTPLLDAASLEYLFAQGQYDFLRGLAPVRAPQNEAEKHEIENECLGMAVLAITHHAKSNDLPLSGVGAETSYKRFIPDSLNRTIKQRNFSHVYVYNNVFKNFLNEFNSKTIQDSNITLYDLKVKYLSTLETLTQGLGRETIEPKILKVSGESDGSPALTLPSGDDGLGYEVQVSGTTGISWRRKPVPNILIVKDKTKSKKNKADKQSKKEMTKRKTVMTIFSDFFEITHIVIKESCATIYSQDNKTMELDLFYRDAALSFAALVDGYFRLTVDAHHYLCTEVAPSSVVQNLENGCHGPICTEYAIHKLRQEGNEEGTYVLRWSCTDYNYIIMTVVCIEMDLCESRPVPQYKNFQIETSPQGYRLYGTDTFRPTLKELLEHLQGQNLRTENLRFQPVLVGLGQPRKISNLLVMTRDREPDSQRQPQVSQLSFHRILKEEIVQGEHLGRGTRTNIYSGVLKLKSEDDDDMGGYSQEVKVILKVLGSGHRDISLAFFETASMMRQISHKHIALLYGVCVRHQENIMVEEFVQYGPLDLFMRRQSIPLSTAWKFQVAKQLAGALSYLEDKKLVHGNVCSKNILVARDGLDGEGGPFIKLSDPGIPITVLSREECVDRLPWIAPECVQDTANLSIAADKWGFGTTLWEICYNGEIPLKDKKLTEKERFYAAQCQLASPDCEELAKLMTHCMTYDPRQRLFFRAIVRDIDMVEKQNPSIQPVPMLEVDPTVFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKPENREEQSSNLWREIHILRELYHENIVKYKGIWHEEGGRSIKLIMEFLPAGSLKEYLPRNKAHIDLKTLLNYAVQICQGMDLLASRNYIHRDLAARNVLVENENTVKIGDFGLTKSIKDNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDISCSPMSVFLTMIGPTHGQMTVTRLVKVLEEGKRLPKPDGCSDRLYCLMRRCWEATPEKRIDFKGLIANFQQMIDNQ

Protein

Tyrosine-protein kinase JAK1: jak1

Gene

jak1

Protein

Tyrosine-protein kinase JAK1

Organism

Cyprinus carpio

Length

1156 amino acids

Function

Tyrosine kinase of the non-receptor type.

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Mass

132.246 kDa

Sequence

Protein

Tyrosine-protein kinase JAK1: jak1

Gene

JAK1

Protein

Tyrosine-protein kinase JAK1

Organism

Homo sapiens

Length

1154 amino acids

Function

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Mass

133.277 kDa

Sequence

MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK

Protein

Tyrosine-protein kinase JAK1: JAK1

Gene

jak1

Protein

Tyrosine-protein kinase JAK1

Organism

Danio rerio

Length

1153 amino acids

Function

Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures.

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Mass

132.481 kDa

Sequence

MPELAVMDLGRQLCVKMKKQRKAEMTIPTAMKGLEIHFYLADTHQLEFFKACYTAEDLCVEAAKRCRISPLCHNLFALYEESQDLWYAPNHVFKVTDETSIKLHYRMRFYFTNWHGTSEIESPVWRHTLSKQKSVLNSQKTTEGTPLLDAASLDYLFAQGQYDFLRGLSPVRPTQTDEEHHEIENECLGMAVLAITHHAKSNNLPLSGAGAETSYKRFIPDSLNRTIKQRNFLTRIRISNVFKNFLNEFNSKTIQDSNIGLYDLKVKYLSTLETLTQGVGREIFKPKNLKVTGESEGSPAQMLPLGDNGMGYEVQVYGTTGISWRRKPAPNQLILKDKPKSKKIKGDKQWNDKKKDSGWTLFSDFHEITHIVIKDCCVTIYRQDNKTMELDLFYRDAALSFAALVDGYFRLTVDAHHYLCTDVAPSSVVQNLENGCHGPICTEYAIHKLRQEGNEEGTYVLRWSCTEYNFIIMTVVCIELDLCESRPVPQYKNFQIETSPQGYRLYGTDTFRPTLKELLEHLQGQLLRTDNLRFQLRRCCPPQPREISNLLVMTTDREPVPQKKTQVSQLSFDRILKEEIVQGEHLGRGTRTNIYAGILKPKSDDEDDLGGYSQEVKVVLKVLGSGHRDISLAFFETASMMRQISHKHTALLYGVCVRHQENIMVEEFVQYGPLDLFMRRQTTPLSTAWKFQVAKQLASALSYLEDKKMVHGYVCSKNILVARDGLDGEGGPFIKLSDPGIPITVLSREECVDRIPWIAPECVKDTANLTIAADKWSFGTTLWEICYNGEIPLKDKKLSEKERFYAAQCQLATPDCDELAKLMTHCMTYDPRQRLFFRAIVRDIVMVEKQNPSIQPVPMLEVDPTVFEKRFLKKIRDLGEGHFGKVELCRYDPRGDRTGELVAVKSLKPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPRNKAHINLKTLHNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIKDNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSPMSVFLKLIGPTHGQMTVTRLVKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRIDFKSLIANFQQMLDNL

Protein

Tyrosine-protein kinase JAK1: jak1

Gene

jak1

Protein

Tyrosine-protein kinase JAK1

Organism

Danio rerio

Length

1153 amino acids

Function

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Mass

132.481 kDa

Sequence

Protein

Tyrosine-protein kinase JAK1: jak1

Gene

Jak1

Protein

Tyrosine-protein kinase JAK1

Organism

Mus musculus

Length

1153 amino acids

Function

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor.

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

Mass

133.367 kDa

Sequence

MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVVPEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNRIITVDDKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVHDLKVKYLATLETSTLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLEYNKHKKDDERNKLREEWNNFSYFPEITHIVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVKTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK

Protein

Tyrosine-protein kinase JAK1: Jak1