IWR1

RNA polymerase II nuclear localization protein IWR1

353 amino acids

Directs RNA polymerase II nuclear import. Binds RNA polymerase II in the active center cleft between the two largest subunits in the cytoplasm. Then uses an N-terminal bipartite nuclear localization signal that may be recognized by karyopherin alpha to direct the polymerase II complex nuclear import. In the nucleus, is displaced from polymerase II complex by transcription initiation factors and nucleic acids, enabling its export and recycling.

Belongs to the IWR1/SLC7A6OS family.

40.64 kDa

MSTISTTTAPEFIRVKRRRDEDSVQALLIDEGKRVKKQKFIFKLSKTVSSESYQSEQESSTPLLKLAHEDHRHFVLEQRKKSRRDSDDEKSQQRLAAEGSTVDDDGLPPEINQMVNDYLKLNKGVEKTERKKPSRKYFTGDSAKIASLPSLDYVFDIYHLEKIHDDEVARYNNEKNIGFVKIIEHIDLALDEESDPNEARSDDEDSNDENYYQNDYPEDEDDDRSILFGSEGEDIAALGEEIVIGVNKSRFSSWNDDKIQGSNGYHDVEEEYGDLFNRLGGKSDVLKSINSSNFIDLDGQEGEIEISDNEDDSDEGDDIEYPRNEFFPTDVDDPLAHHRDRIFHQLQKKINRS

iwr1

RNA polymerase II nuclear localization protein iwr1

277 amino acids

Directs RNA polymerase II nuclear import.

Belongs to the IWR1/SLC7A6OS family.

31.711 kDa

MPLPVLRVKRKASEDPVNALYLELGNNPNSVSSTKRRKFAGRYYFKLSQTLKQDDRYIQINDESSEPTHEDVRNIHSHTKISSLKKNNYGIPVVQTSEDVVKAPTHMDLGSRENTKGILSFSSPRYTIQNLPSTQSNRVFDAIRVEQGHTTYHPHPQLDSMIQEYLSNGDLPLQQSTEDYVYDIYEASSKEPNKPTFAYGVIDALSIPDAFRSSLEQELVSETVDSDKDDPLHDEIDEDSNAESFYQNSYPDEDEWQDSSENDEFAYSDDAEQDFYD