About Products Protein Database Contact

ispH2

Gene
ispH2
Protein
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
335 amino acids
Function
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Similarity
Belongs to the IspH family.
Mass
36.297 kDa
Sequence
MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVETVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR

Gene
ispH2
Protein
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
335 amino acids
Function
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (PubMed:23091471). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Has a higher activity compared with LytB2 (PubMed:23091471). Is essential for M.tuberculosis growth in vitro (PubMed:26309039).
Similarity
Belongs to the IspH family.
Mass
36.297 kDa
Sequence
MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVETVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR

Gene
ispH2
Protein
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
329 amino acids
Function
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Similarity
Belongs to the IspH family.
Mass
34.666 kDa
Sequence
MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ

Gene
ispH2
Protein
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
Organism
Burkholderia mallei (strain ATCC 23344)
Length
326 amino acids
Function
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Similarity
Belongs to the IspH family.
Mass
35.162 kDa
Sequence
MSSTDTLSGQVAAADAEILLAQPRGFCAGVDRAIEIVERAIAMHGAPIYVRHEIVHNKYVVEDLKKKGAIFVEELEEVPSGNTVIFSAHGVSKAVRDEAAVRGLRIYDATCPLVTKVHVEVAKMRQEGVDIVMIGHKGHPEVEGTMGQVERGMHLVESVEDVRRLELPDPERVALVTQTTLSVDDAAEIIGALKAKFPAIREPKKQDICYATQNRQDAVKFMAPQCDVVIVVGSPNSSNSSRLREVAEKRGVAAYMVDAPEQIDPAWVAGKRRIGVTAGASAPEVLAQAVIARLRELGVTNVRALEGIEENVSFPLPRGLNLSSAA

Gene
ispH2
Protein
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Length
320 amino acids
Function
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Similarity
Belongs to the IspH family.
Mass
34.614 kDa
Sequence
MLAKSPLKIVLCSPRGFCAGVVRAIDTVERALALYGAPVYVRHEIVHNKYVVDSLRAKGAIFVEELEEIPDTKAPVVFSAHGVPKSVPEHALSRNFFSIDATCPLVTKVHREAAIHFKRGREILLIGHSHHPEVVGTLGQLPAGAVTLIETAADAEAYQPKDPNNLAFVTQTTLSIDDTAGIVTVLRERFPNISGPHKEDICYATTNRQAAVKKVAPVVDAMIVVGAPNSSNSQRLREVAEREGCKVAVLVQRASDLDWSQFEGIKVLGLTAGASAPEVIVEEIMGAFAERFDLSVETVSAAEENEFFPVPRVLRPDAAE

Gene
ispH2
Protein
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
Organism
Burkholderia pseudomallei (strain K96243)
Length
313 amino acids
Function
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Similarity
Belongs to the IspH family.
Mass
33.769 kDa
Sequence
MRVILAQPRGFCAGVVRAIEIVERALQQNGAPVYVRHEIVHNRHVVENLRNKGARFVEELDEVPHGAVAIFSAHGVAQTVEQDAQARGLDVLDATCPLVTKVHVQGRQYVAAGRRLILIGHAGHPEVEGTIGQIPAEVILVQSEAEVDTLTLPADTPVAYVTQTTLSVDDTRGIIEALQRRFTDIVGPDTRDICYATQNRQAAVRELSEQVDVLLVVGATNSSNSNRLREIGTESGVPSYLVADGSEVRAEWFANARTVGLTAGASAPEEMVEDVIAALRALGPLEVATMSGREEKVEFKLPAKLTQAVAREV

Gene
ispH2
Protein
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Length
308 amino acids
Function
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Similarity
Belongs to the IspH family.
Mass
33.269 kDa
Sequence
MEVYLAQPRGFCAGVVRAIEIVERALEKFGPPVYVRHEIVHNKYVVESLKNKGAIFVEELSEVPPKAVTVFSAHGVARSVEEEAAARDLPVLNATCPLVTKVHNQGKRYITKGRTLILIGHAGHPEVEGTMGQVPAPVLLVQSVEEVNALTLPADTPVAYITQTTLSVDDTRDIISALQARFTDIQGPDIRDICYATQNRQSAVRDLSKLVDVILVVGAANSSNSNRLREIGTEAGVASYLIADGSELNPEWLKDARTVGVTAGASAPEVLVDDVIEAMRRIGPVKVQVLPGREENIEFRLPAELAAS