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irs4

Gene
IRS4
Protein
Insulin receptor substrate 4
Organism
Homo sapiens
Length
1257 amino acids
Function
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Mass
133.768 kDa
Sequence
MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRHLGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVDRGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPMAPQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRGLDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYKIKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYVNVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASALAAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGDNQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR

Gene
Irs4
Protein
Insulin receptor substrate 4
Organism
Mus musculus
Length
1216 amino acids
Function
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Mass
130.147 kDa
Sequence
MASCSFSGHQALRRLRASAAAAASAALAAVATTPLLSSGTRTALIGTGSSCPGAMWLSTATGSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYRNARKFRHSVRAAAAAAEAAASGAAVPALIPPRRVIILYQCFSVSQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGALPDGEPAALAAAAAAEPPFYKDVWQVVVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDSVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSTRRHLGLLPLEPGGWLRRYGLEQFCRLRAIREREEMLFTRRFISPREPPPPFRRGRGHLPRARRSRRAASVPPSLFRRSAPSPGRIPQPEDVPNDRAREASGSSSGNTEEKDKEGEEGNRGDCIPMNNWGSGNGRGSGGGRGSSGQGSSSQGSGGRQGSGGGQGSGGQGAGGNQCSGNGQGTAGGHGSGGGGHGSGGGQRPGDGHGSGGGKNSGSGKNSDDGDRGKSVKKRSYFGKFTQSKQQQTLPPPPPPPPAAGATGGKGKSGGRFRLYFCADRGTKERKEAKEVRDMETSGGATRGPYRARAFDEDEDDPYVPMRPGVAAPLACSSDYMPMAPQNSSASTKRHSRSPFEDSRGYMMMFPRVSPPPPVPSAPKAPDTNKGDDSKDNDSDSDYMFMAPGAGAIPKNPPNAQGGSSSKSWSSYFSLPSPFQSSPLGQSDHSEYVPMLPGKFLGSGLHKEASFSQGTKNVSSKPSTEASFSKPEDKGSSAKPSDDVPPMNKAKEPNHLSFIAKGTQVKPKPLNPTQERREAAGSRDYINIDFIKRERLVLPSSAQGLPDMRGVVTDPAPTAFSGYLNVEFGVPFPNPTIRLSDLLRVLPGANSIPLAGTRWPFPGSAIGSIVEAGEYIEVIFNPAMTPAMSFADSAICYDAQTGQIYVVDPFSECCMDVSLSPGRCSEPPPVARLRREEAQERRRPQSRSQSLFASTRAAVSAFPTDSLDRDFPAASAVIAAPAEAPLLAVSRALAVVSALAAAPSIGDVFAGFRAAAGVDSASARGFQPVAGAQAVREFQDLAAGWNPGALNHRARGEDLAAGAAAPPPPPRQIWVLRPQERADSEDDDDDDDDIYVRMDFARRDYRK

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
1005 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
110.19 kDa
Sequence
MSALSASLAAAAAAARASETSRESNNVAVTKARPPQHTLVKPAPAKPPRPVARRPKQPVKITVDTSVANTPAPQGSSATSAAAAAARHFKKQKDEQSSPKLSPHHRPPASHRNSGESAKTPSSDSRPASTTSTIPVTPVSATTPSSTVAAAASAAAKRSSTFNKSVPTPVVSDIMKKEQEENRAAAAAAAAQEKATQIIRDLPSPSNSVRSKRLSQSSLVPVLSDEDIYNHRRYARSSQSFATIPTDEDSPGEMGDFEDNNQVHRERARGIQSAAKHANRLSQTSMDSTHTSQQLQPVVSPHTGLPQEGSVLAAALKAGSNASSTMERISLTNEAKEREKAEKRQRKDAKAKAKLLAQANAVYQQSTNESHHAHHHQYHQGNIFKRVIGKSGKPIDPFQGFSPNFSERPGEHFHNHQREMQGAPDGIRRSMDTSRQSIDAPRQSLDAARQSIDTPRELTTNDTSPIPIQPLKSHDAGAVSDLPTSLDEPGLSGHPHLQQSFSNNNALQTVKSSTDDSMSIASLDSVDDSGPGRPPLLAPIPIRNASIIPVSSESESEDIRRGHRRHLSSSQSQRNSLQFPMSPTFSASPAKQLITPEQLLPKRRRGIARTPSVSSSAPRSSSPVISIPLERSSTLQSTLQGSPMNSPVAKSPVFFEGNNGSTNGGLGSSMSNSPPDSELALTPSESTAHSYFAREYREPKSSSTRGVEGASRLAKKLPHRHLAAGGKSIVKSIWNKATPDAPPPPPVSTGGMKTSLRKQPKKKFNEDKPWKHHNDADTLTDADRKRYDGVWATNRGAHVPYYMEPEEYDILIDEEEFYDEGFLSDSDFTDSDSDDDSVSSAEYIMSGENIGNDDVVVSDQNDAVHGYIVSRLWRRSRLPDERLSDIWELVDRCNDGTLDREGFLVGMWLVDQCLYGRKLPNKVDPRVWGSVGRLNVNIKIRQKEPKRNSAKRKARRKVRRDRKELVRERERNEKERRKDEKKEKKDEKKDKKDDRRRDKKRVGEA

Gene
irs4
Protein
Increased rDNA silencing protein 4
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Length
923 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
97.434 kDa
Sequence
MADPIFNGDASDTKTAKLTRPVTGTSTAARNTQQSAAFENSASVSASTSTLQSTTSSTPRINHNPSINSLRNTHVGGAGTETGRGISAAQNAALTGASLAFSNAKEGRAKARVVPPVPNKGNVQLGEKGLNGNGGALAAAAKAGAVGHNAGGGGRTRSPSKVSAMDEGTVHGQHILGSEKTGESQTTDGGSINGRLEHQIGHTGLQKRKQRSNGHLLPPFSGSGNSMTEHGANMKSSSAAFMAANLAAKRSRESSPSQSHGTGIGIGGGLGKQGSPLMSRRQSYASSIDSLDRRLDVSSIPPTSNLVGMWEQANRGVKKGGAGGGGESSSDRGNEVVSRQESLRRPASSHAPVPVLKPEGLTRPVSSHVPDVELVKSSATKPAVQPPNTSSQASISDEIKSPGKPAVQPQIVYSHTSELEPKKSAAKASVPLRPSSSQDLISEETKSTSKPAVQQRPVSSYTPGSVTLKPSSKSPAQKPVIHNTRPVSSHGPSPNFSAKPSIQKLSRPVSSHSPPPTKPSAKPSSQSIRPISPRAMESTESLSKSPVQKPSIPPSRHTPADAPALNTQSAKPQVQAPRPLSMHSPILKPADRDEPSLKPPVQPPRHSSTKTPPKSPRPKPPFEPPVSKQSYNNNYDDDDGSSDDSFVSASSQPKPKSPSFRAKIAQQKRSQSTSISSMNVNSLANAIVAGSLASSRASTPSISSGTTRAPAPPPTRRHKNLHIFHSDNSRTPTPPHNNGSAAGVPIMKTTMRKPKTGKELKEEEGEGEKRRAKKHLVKKHPNKHNEGNRKRWRDGITERERKRYEAVWASNKGLFPYTINQDGEMVEVDGAVDTVPGIVVRDIWERSRLGEDVLEEVWGLVEGRGYRSRLVANMKAGGRLEKDEFVVGLWLIDQRLKGRKLPGRVGSSVWGSAGPMGGIKIRS

Gene
irs4
Protein
Increased rDNA silencing protein 4
Organism
Botryotinia fuckeliana (strain B05.10)
Length
885 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
94.374 kDa
Sequence
MADAHSDGRTGSTTPGKITRPETTGTKNTHSDNASTSAPGNSASASASASASASTSTLHSNSSTTTSSPQRMINHNPSTSSLRNINTGGTRIETGTGRGTGAVQNAALTGAALAFSNAMGKATPVVPNKFAGKTQLGGNGLGGKDGALAAATKVRVGGGGSPNNGGGRTRSPSKVSVTDPGMGGEQQIYGYQKVGRERTGESETDGGSVISGGLEYQGGQRIPQKRNQRPNGHLLPPFSGTSETSPNVKNNSAAFMAANLAAKRSRENSPSHTGQNYGMGMGMGKQASPLPSRRQSYASSIDSTDRRVDLSSIPPTSNLVEMWEQPDKGVKKERGLVSNRGNEIVNRQVQKRPVSSHAPIPVLKPAGLTRPVSSHASESSVQSRIASSQAPISEQVKSKPKPVIHPRPSSSQASVPGPSKPVSKPDVQPPPVSSHTTSSEAPKPSPKPPVQKPAIYNTRPASSHGPVPNLSTKPSIQKLSRPVSSHGPPPAKPSAKPSLQSIRPTSSHTLESTESSSKASVQKPSLPPPRRTPANLSVSGDQSTSLPMHAPQPRSMQSPILTTADRTEPASESPTQSPRSSSTTKTPRRSSKPTLPSRPPVSRQSYNNDADDDESSDDSFVSASSQPKPKSPSFRAKIAEQKRLQTSTYAPSMTAKTLSNAMVAGYLASSRASTPSISPGVIQPPAPPPPRRLKKFFHSEHSRTPTPPQNTLSATGVPTMKTTMRKPKTEKELKEEEGEGEKRRAKKHLVKKHPNKHDEGNRKRWRDEITEKERKRYEALWASNKGLFPYTMDPRGEIIEIEGAADTVPGMVVKDLWERSRLGGDVLEEVWELVHGKGYWGRQKQKRFGRLERDEFVVGLWLIDQRLKGRKLPARVNHSLWASAS

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
882 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
97.78 kDa
Sequence
MASGTAANAAALAAFNAGKKRDDGWKQNNEGNNKSSKYVCAPAVKSQNNKVKPAAPAAPAALAGAVNTNTTNTTNTVTTTSASTTPKPKSNHAVHRDTTPTSMVNQQYSQNNDRIMTKSPRPVLNVNTDSSKQGSYSSAASKNNHDNKGLDYFNLGSATSGRSDTFKLPRYLPHTPKDMINNVKSSIEAKNIANDPSSRRLSANYSPQQMLKNLKTSLNEKSKAPAPPKASENDKGRQILSDMRERLDTSRKIAADQAATRGLAPGFDFEEDGDKEDKGYEDYTWNLTDRKKPVSSNRSAKSFKSFKSVKSTNSNKTVNSIAKNVVTKAGENDQLGTTELNISTPERHGICIDVTYHDSDVEDDCLKNENGNKCANGIGHENGHGTQNENNVENGIRNENQHDNESDIGDQVMVPIKLYNSDKSSISSKSKVRRKPPPSLSQEEYGSSSTELLSTDLKHIMALHAKSSDTFSSGDNFNQSDDQISIAENDAGQPNVGTTAAATLVRRGDTKFPQFPEIKKKHYHSRNIFGLKRHDHRNQNSVIWLDPDSDVEAEGEGLGGEAKYVRGVNRKSAGEDDELEEEEEEEQDGEEEEEEEEEGNEVEENEESEFSDASAIANNFNHGNTKNGVRRLGPQSRPQQAHVQQQQPQQSQQQPVQFRTTMRTTNKRKDRKSKFDEYKPWKNHSDLNYLTDQERKRYEGVWVSNKGNYTNLVVVKLHGVDYSTVKDGKVNLEHIDDSMRAALISTNAYPSSKQEEQESMKSNNGTGIKVNSDGSVYNSAIEVPSQANNQSRPERVELSQLILGAVVKRIWSRSGLPDETLEQIWNLVDFRRDGTLTKNEFIVGMWLVDQCLYGRKLPKKVESIVWESLGGIGVNINTKKMR

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
870 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
96.331 kDa
Sequence
MHMRLNKRRRNHVQEQMSELPQDAKNDSLAAAQVIFKRHADNANSTPPSPVGLDSAGHLDKQADTAQRVHKVGTPSGTSSSHNSGNEGMHKVTKPLGENTATTAPIAIKQPVRVVRASPTAIVSPTSHTPLDAATAAANVVAEKSKIRTTQQQLQDKKRRDIENAHHAASAAAVTSSNLAVGSPPSQYIPSVPTLNVTSPQMRNSSQNIDRRSKSNEEAHNGHEKMMNSRSNSINSSTIKGSVSEPNTVTPLRQNSPSNMDDIIQKMEAVDIDEGRKNSFVMNGSGDSVDSLKPNVVRRPMRTPSGRRVRPPSPIDKIGSIQEPHLESTGFNDQNDFSEMSSLIDGSSSEDITKIRGSGIRERSPVDGVEHGGMSVNIPMQRSLSSDVLSPSQQAAMVAATKLSPSTQTLPVEELEYLASTGDVSAYKALNKINGTNMAYKGTIPDLIPSRARAQKTSKLKFKIFGGGKNSDRRNNATPIGYDPVMNISTDFGGKKVVESNQNNVKFKTTMRSQKYLGNDNLDDNDLRTQYIDDDDDDDDYDSAYEDLDYSRDDSEAMYKGDRESSNPRSNSLLQSSSYSGKVGFNSNANSGTSINNSGNVSNLDYSLRDGVAEKKKSRRDKIKKKLKSTASVVPYYPHYALTHLASGVSTVNSNLNNSNKNTKWFNEDKPWKSHKDVGFVTSQERKRYEAMWVTNRYLYLNLLPWWPKEEVEKDEDDSASNLNSNASTNVGGVLSDGDNEEDDVTRFLLSLPADGLMLNLVAKDIWERSNLPNDLLKQIYDLVDTRKDGTLNRESFLVGMWLVDQCLYGRKLPQELDPKIWDSVDRWVLNVVNSTMMTALERKQKKKMMKKELKNIKREQKQAIAEQHN

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
765 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
86.251 kDa
Sequence
MASNNSTSQLAALAAFKAINNKKNEESQPNNRSRIPLKVDTTAPPQTQMKALNSATRAKSSNKISQTQADKTRGQTSERKDQKTTPTGSNMTNIFKMPNTPKTPKISKSAETPNSVGASRRSSTYSNSFAVESLENEPPKNDNFGEPLSTVNNLERRKTVSQHSLNYDPQDMIRNVKNSIGSKYISNDLSPGQVNTKRLSTGTQPKDMLDSVRNSINSKTKTNSKNQEMSQRNALILNGIRDSIDSKRISSHHDNSTISLPLAEERDKILKSISKSNNPEEQLMLYGQPIYNYSSSSFASSFSENDNDQLRTPVIIRTDMDLLDPDSNASIQHDERENYSNEDDDFEYNDTYDTKEDKEVSPINIPLSSHACARLGISNNDTPKTFMNLRIQTPDKEDSSRLKPKRKPPPEMDNDSISPTFTEQSDGYQTEGDDRMSDASSNRTRRHSVQYNDYGGYSDASSKSQIKVNDDSDYSYFDESDLSGSETPSVEKIDNDKSFLDDRLPIFPDIKAKSRKLFRNRKSKPIYNSDDPDTSKSDLQSATEELKNISVPSRTSTPVMGHQSQPVQLKATMRTNKKREKKYSFNENKPWKNHSELSYIAESERKRYEGLWVSNKGLYINCAVSRFIGVDYNGKPEIESQIENQDAPTTAALLSSRTTNEDNSNVVQQNFHNLLSAETSQLIHGVVVKRIWKRSRLPKETLEAIWDLVDFRKDGTLNKPEFLVGMWLVDQCLYGRKLPKKVDGTVWNSLGNVGLNVVLKKKGRR

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
744 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
82.631 kDa
Sequence
MRFRSERQSKILSASNGEAGEVHKASLKAAQATFKKHADGARVNPRVPSAPGNSKGSMDGLVDPIAGLQLDVSGRRSKRGLVGRSLPPGGSANNINPRRISSGVSCGEYDYKVAAAAAARAARNENESIWPPTNAQHASPLLALPPLKLAGTHTRSSSNISMSTLTSGNGSHLSLDEIIATIKVNDPNSQISLKPPTSRRSTQTGAYLSSRESPRGGVDNSTESLPAGGSQYSPGRLHIPPIVINPALLGKDSQAILACSESQASPSHCSETTSPPPNTDGPVLPVRPPAVSSPIQSTYSFRSFSSNRMPRRIPPPCDPLSQLTKNEQKAVPQAAPLLESSEYSGGDSDYDGKQYSKACISETDSALEDDDDFGSGYENFSNAEDYLSSQDDFRERNDNNDNDDDDELDDDNLVESENDATMEQDSQSDDDTESAKEFTVANVSYSTLNKIPMNMTYRGTLPDLIPNYQRKQSKWMKLFKRHGQTGLGPSKNHPPTSHIYTQNDNALVQSKLHVRLKTTMRGILNDSSSSEPHQLSDDSEDSEEDYGSDRNSRSRSPGRRSGKKREKIRQNLRYRNSFNEDKPWKSHLDVGYVTERERKRYEGMWVSNRDTYLDLLPWWNNGNYDETREVPEDGLMLNLVVTDIWSRSNLPQDTLAQIYDMVDTRRDGTLDRNSFVVGMWLVDQSLYGRKLPRELDRRVWDSVDKYVINVNGSNKNPKHHHRTRKKLLKKELKLIKKESKSHNV

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)
Length
741 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
77.173 kDa
Sequence
MGAGLAPRGANGALLAATQAARGHAAAGGGNKGVNEGGSAAAAVGAGTGSGSGLDGGHGHGGGLVGQRVLDLHAGSGSGGGGSTLLPPPAGRSGADGGGGGGGRKSSPSLIAATLAASRSVSPARGPIPQLDLNGGGGKVTRKRGQSVGAASVIVGSVGPRHEAEVLDTASIPPTTSLVSLFEGKREANDVDPVKKRAPSVRRKDMDTEEQARKERASQEPQKVKPKPVPKPKPKPEVATDVAVPKSSDDAHGASEGTSRLGGTGRSGHGDERGRAEAKPSQRRARSQHSEHKPAKKPKPAQHRPPTPPPSLPTRSPSNHVVSQPKRVAKTPRLEPPTPPVKTSTIAKMAEPIVQVTPVEPDIDQVDVFHHQDRNPKPRQVSQGSTSSNDSFVSASSVPSGAVSPVREVESTPRRPAPPARSPSSRSISTPNPPRQQASHPSTPNLTLSSLTNAMMASNLASARLTPTTPSQPPPLPAPRRSGRSPLQPHHTADSIGSQLTGGSKSPNHAAHQQKQRTGMLQTLRSPHASLSDDEDARRQHHHRRRSKVLSGGNRKHAHHEGSRRRWRDEITARERKRYEAVWASNRGLFLRPGWAAQYQNTTTATTGGASPTQQGHGPGTGEETQHQTRDQAVEASRASHGAEAELVVNVVARDIWSRSRLPADELAEVWDLVDRGARGALGRDEFVVGLWLIDQRLRGRKIPARVSQSVWDSAAGGYQGVVVPLPGGGAGGGGRKGRRA

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
680 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
74.009 kDa
Sequence
MTIMTSPAHRPPASSLSIPHEQAQSAALKGASLAFQKQLDASKKKASPPGPNHNNKLTTDPRGGALVAATSAASLSNQTTGGSSVADHHHGVPEHATLSSRLAQLQQRSGSPHLRPPGNAGGPRSASFIAATLAASRSTSPSPSRKNSVVTPQEQRRRAGAHSRASSVGSLRLTSPSNLGPSPGQGVDYGGYDGEDDADLDHDEDTGFRRLGRRKVVAETPTLPAREQSRRRDGDPVKSPSPVRDTEVPQPRRKVIDRVPEQEEPASPVQKPRPKPKPKPKPKPEKIIKTEPRAAPEPVESKRAEQYPGSEPTSPSIRRASVQQPKPKVARAQPARTPIKAYHSQKEIQVLSRILMPKDVDDIDCGPLTLDGAHGPPFRERVDSISSDDTFFSTSSGQGRRAPTPPPPRRIRSVRETPSRPHSEATTPSSQQRSTSSQSKQTPTSANRSSLALDSLTNAIVASSLASARHTPASRSQTPAPVPVPSRKRNDRLASNLTGGGMSRSHSRSPPKKQGMLTTLRAPHSKSDDEEARKHKERHRKRGPLGGKKHVHHEGSRRRWRDSVTAEERRRYEALWASNRGLLLPPKDGGVGQQHQQQQPEDLVANVVVRDLWSRSRLPHDELAEVWDLVDLGRRGSLSKEEFVVGMWLIDMRLRGRKIPPRVSQSVWDSVKGLRVPAPA

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
667 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
73.894 kDa
Sequence
MSAGQSTSQAAALAAFKSISTHPKTDQNPSKVHQSPERNVKRNPSGRLTNSRNATAVNAINRSPPKAPQKPQLSVVTASGHETKKNVENNRQRSSSPSPLYRTTTPKQMTSPSTSSASLPSNMIKSVKDSIEAKRHASEAKRLAQENQPSDMLTKIRQSINDRTRNIPNQAKVNERNMATINGIRESIESKRITTQANSSMIVLDTSSNSPYNFAPPDELRSPYEAHSPNYSYSSFESVPSAYSNPDSNIDLHDRGPETPSIVVDSPFNSQYDLSSPREDSDIDQERRNTAPILIPPSSNACARSANSAGSADDARSHLSSLKYQVEKEKNEDKNKKPKRKPPPELKPTTDLDGAFFSDSSSLNPGSSRSSLDAGSYSTDNESMGRNRMGSNDSDLSKPIKLPQYPELDTSSTKFKIRKRHGESNQNVGKMTESGSESDFEYPKATVPVSRATAPPLVHQKSQHVQLKTTMRDSKKKKKDKKSFDVDKPWKNHSDLDRISEADRKRYEGVWASNRGTYFNYVVTRINGIDYGSGGGSEQKIIVDEEDSMKAARLSAKQQADTVSGANGGYQSAEFHNITNAEISQLIHSSVVERIWERSRLPSETLRDIWELVDYRKDGTLNKPEFLVGMWLVDQCLYGRKLTKKVPASVWESLEGIGVSVKKKGKR

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
638 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
70.365 kDa
Sequence
MRFRSRHQVDKPNVIVTQSNRKNEDRLGEDASLKAAQAMFKKHTVSQGFAVSDAPGTKLSLPNSGHGTPAHNVQAMARSSSSSSATSTPINIIRRSPRSSLKGKPMGGLSVSPRTVEGNAALSQQAAAVALENEISGDESIVLVPAGNSNGSMTRSNSSINAIRIVPGGGLSSSRSSSKVSIVKNSPTHSLALADKLNSITLESVYGKPSTATGTATRTLAGRKAPPAAFIDQDSVLSNDKHSENEDTPIKGTISYDTTARMNVPVTYEGTLPDLIPGHQRHKKKKWRNIFGSSATHGSSAGGAIGINGTSASGNDQYENPSGTLSELQLNRAEDNLIVKSVNPTQKTRLQTTLRSNDYDRNSELAAVAGGYSSDESAFSSDSDRELHYATDNHHNNSINNHSSGVYYGNVGGNGVYNGGTAGVGRTKHRAMVRSHKRKSFNEDKPWKSHVDIGYISERERKRYEGIWVTNRNSYLELLPWWNQPLQDEEQEQEQEREMDHESQHGLEEELEEEREQESGQGQEQDADIPEDGLMLNLIVMEIWSRSNLSNQLLGQIYDKVDTRHDGTLNRQSFLTGMWLVDQCLYGRKLPKQIDQRVWDSVDKFVISIPNNNPHHRHRRRKKMLRKELKTIKKDLKT

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
638 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
71.771 kDa
Sequence
MSGNSAANAAALAAFNGIGKKKKESTTKLNGTDNNTNHLGVIGSTSNQTKQHQQQQQQPQALRTPLPAHPSRKKSNKFSQLKRLNTAPAMASLQPALQIASPSISPTQPSAPASALDSDPDYFTLSPHTIPSKNEIAKSPQTPQDMIRNVRQSIELKAIPNNAQAKRLSVDYSPQEMLKNLRHSLHSRTKTSPMLTTSDKMGQTMLAEMRDRLENTRRIASNSVASLSLSPNLDFNKSTSDVSNLSHHYDVDTVSTDSFASFNSSINDRHLPHGISIDVTNHDSDEDEIDDREREEDHEPLDNGELKSTNNKVTVSSRLRRKPPPGEDFQMQLNDKSRDTISSGSYSLNPDEVYSFTDPDSYENLVSEVEVGETTRLFPQFPDANHYHQHSSKFRKKHQKVKPINGIYYRDMDSSNTSDTEESTSNLPSRSTTPLLGQPQQQVHFRSTMRKANTKKDKKSRFNELKPWKNHNDLNYLTDQEKKRYEGIWASNKGNYMSQVVIKLHGVNYETQKDPKEEAKMEHSRTAALLSAAAVEDSNYNGNNSLHNLDSVEINQLICGPVVKRIWKRSRLPSDTLEKIWNLIDFRRDGTLNKNEFLVGMWLVDQCLYGRKLPKKVDNVVWDSLGGIGVNVTVKKKK

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
628 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
69.743 kDa
Sequence
MSENSTASHAAAMAAFKSLANNNTSSSSIPSSYKIPTSAESAKIRSPTPLNSNAAVPQNRPKRAATSVGVKSTTKPMAKSIATPISVKPSKANGFVSGVNKQRAPLPLARADSSLKSSRRYPQSKGLQASSSSSTMPKDMINSVKQSIESKSVGKDPSQKRISSLYEPQEMLKNLRSSISAKTVSGTSVRPMISEKNQAMINGIRDRIDSKRIVTDVSKTSSLSSEDVSHLQGHDLANTHTYQPLNNNDSFSSFGSSFSEVEPSSLSKANGEEDEESIIDNASATVQEHPPVNEEVAKNMNMDKTPKAKPKRRPPPDLVSGPREETSIPMFHDKSVESLPDGYSSTDADITLENDRNSSQSKFPQFPDIKKHKKTEKKGNFLKKYSRPLKCVDNEVNLLDSDEAEEEDETDSSYGKRAPQILTPPTQQVRLKSTMRKTNRRKEKKYMFNENKPWKNHNELSSISEQERKRYEGLWASNKGNYMNSVVTRLVGVDYDSGKSEPEVEEEEDSRKAARLSSKAGTFDSGKMSDQENFHGLLSVEVDQLIHGVVVRRIWKRSRLPRETLEAIWNLVDFRKDGTLNKPEFVVGMWLVDQCLYGRKLPKKVENEVWDSLGSIGLNVVVRKKGKR

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
615 amino acids
Function
With TAX4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Seems also to be involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
68.91 kDa
Sequence
MRLSFGKQRYHGGTTVTLTEQGASDSLRAAQAIFQNHSNEVSSPCPPVTVSRNPQTRLSEPSLQKSGRKQEQKKARIRTKQVPKIKTTAPNDVELSKKHRSSPAGKDNVSSTAQMAAALAHSQSKLSSDNNSSHSSALDTLKVLETPNLNGLLGIHSRSSSRNGSNESLTPGQRTPDNRSQENLLTSFSSGRRLSSSSMEPATNKDSNKALPKRRPSPPLQSSLVGSGQLHENENLSSISIDSRHSLNPDTSDVISNRSQTSLSQTINQLSLCESEPSIASSNTTTTTSNQGSGLPNLVPNYSSDMRKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTSVSTNAENDHASSLHEGNLRYKYNPSNDTYDVYDDTDSDSESDQNQDALTKPRKRDRIKRKIRNSANKTAHHRPIHRTRDRKFNEDKPWKSHTDITFVTDNERKRYESMWVSNRHRHLNLLSWWPSLTGDSGAINTLPEDGLILGIIVRDIWKRSNLPNSLLAEIYTKVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLPNVVEQCVWDSVDRYASTMVVPVSTLKAMAKQKRKQMKEEIKNIKKENRVVLVDHNSSS

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
615 amino acids
Function
With TAX4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Seems also to be involved in rDNA silencing.
Similarity
Belongs to the IRS4 family.
Mass
68.88 kDa
Sequence
MRLSFGKQRYHGGTTVTLTEQGASDSLRAAQAIFQNHSNEVSSPCPPVTVSRNPQTRLSEPSLQKSGRKQEQKKARIRTKQVPKIKTTAPNDVELSKKHRSSPAGKDNVSSTAQMAAALAHSQSKLSSDNNSSHSSALDTLKVLETPNLNGLLGIHSRSSSRNGSNESLTPGQRTPDNRSQENLLTSFSSGRRLSSSSMEPATNKDSNKALPKRRPSPPLQSSLVGSGQLHENENLSSISIDSRHSLNPDTSDVISNRSQTSLSQTINQLSLCESEPSIASSNTTTTTSNQGSGLPNLVPNYSSDMRKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTSVSTNAENDHASSLHEGNLRYKYNPSNDTYDVYDDTDSDSESDQNQDALTKPRKRDRIKRKIRNSANKTAHHRPIHRTRDRKFNEDKPWKSHTDITFVTDNERKRYESMWVSNRHRHLNLLSWWPSITGDSGAINTLPEDGLILGIIVRDIWKRSNLPNSLLAEIYTKVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLPNVVEQCVWDSVDRYASTTVVPVSTLKAMAKQKRKQMKEEIKNIKKENRVVLVDHNSSS

Gene
irs4
Protein
Increased rDNA silencing protein 4
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
552 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
60.419 kDa
Sequence
MAKPSTPSRRVVLPRSLNNSTVNPPASAAALQGALLAFSHAVPPKPQSPMMADRPPVSLLDSDPDPPSELPEPGSIKGKIALFSANSTATAPSDRPRSAHESVPEIARQKSPQLLAAEIATGSVQGPGGKTTSDDVQRTRLQRNGAVPSRDLSSPIPVRKPVINPRLLDPYQDETPEHSPPKPGSDQRPVSSKSSASPRPPIRKPRPVPPPIPRKPSPALSEPASKSASHRFENGLRRDEARKPPLPLRSKASAATLSEERPPTLPPRRAATAHDLYINQSTPGRAESPAGLSSSPSVVSLYSPAHNASRTSVHTVASRDAPSDAVAASSTASNRALQARKSPPPPPPQRRRRSRSRSLLHVQHKKDRTPNPSPGGLRETLRPQARSDDEDEQRRRQHKSHIINKHPHKHNEGERRRWRSEITEKERKRYEGVWAANKGLLIHPSQVLDENLEPDKIPPGMYPPAALDMVVNLVVRDIWSRSRLPNHVLEQIWNLVDGQKIGLLTRAEFVVGMWLIDQQLRGHKLPAVVSESVWASVTRVPGISLEPYNTKH

Gene
irs4
Protein
Increased rDNA silencing protein 4
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
513 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
56.845 kDa
Sequence
MDDKSRGTTDAQHHATDADRPPDDGSAGLPEPGSVKSKIGLFTAQSTQKALEGERDKSATFRPRPPQQAAAQLAMQKPPVPVNKPVTLGRMNSTPELRQTEPQGSDDRAEPDLPMPKPVRNMTADADTVEKLLQDNRELPVRNPPILHRNPAMQPATSPRSPDIASVSATKPRPPPPRKGGAKPVPKSPSRSEPKIHGGQQSYEPLSNSDMDLTGADEARPKLPRRPDASPVTHIPPSDHRVLLEAHERSKRHLAPSSPLLDRSLQNNGSSPDLIDYSPGLDEEAMSDAIVASSLASRKAPSAKKFPPPPPPQRQRGTHSLLRPNTSNSDSPRSSSPASSLRHTLRPPTKIGEEEFDHHKHRKHIIHRHPHKHHEGDRKRWQSEVTEKERKRYEGVWAANKGLLIPISNSKERSSHEETSSECYPPSASEMVLNIVVRDIWARSRLPSSILEQIWNLVDRQKIGLLTREEFVVGMWLIDQQLKGHKLPVKVPDSVWDSVRGVPGIRIPKVPSR

Gene
irs4
Protein
Increased rDNA silencing protein 4
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
513 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
56.75 kDa
Sequence
MDDKSRGTTNAKHLATDTDHPPDDGSAGLPEPGSVKSKTGLFTARSTQKALDGERDEFATFRTRPPQQAAIAMQKPPVPVNKPVTLGRPNSTPELRQTESQGSDDRAEPGYPMSKPVRNMTAGADTVENLLQDNRELPVRNPPIPHRNPAMHPDTSPRPPDIASVSGTKPRPTPPPPRKGGAKPVPKSPSRNEPKIHGEKQSYIPLSNSDVDLTGADEARPTLPPRPDPSRVTHIPPSDHRILLEAHEHSKRHLTPSSPLLDRSLQNNGSSPDLIDYSPGLDEEAMSDAIVASSLASRKAFSAKKVPPPPPPQRQLRTHPLLRPNTPSSDSPRSSSPAPSLRHTLRPATKVGEEELDHHKHRKHIIRRHPHKHHEGDRKRWQSEVTEKERKRYEGVWAANKGLLIPISNSKERSSLEEVSCEGYPPSASEMVLNIAVREIWARSRLPSSILEKIWNLVDRQKIGLLTREEFVVGMWLIDQQLKGHKLPVEVPGSVWDSVRGVPGIRIPKVPSR

Gene
irs4
Protein
Increased rDNA silencing protein 4
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
504 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
55.104 kDa
Sequence
MEPVGVSHNTPEMDPPRNIQTPELPESGSVKDKIGKFSAYQQQPSGLKDAFGKTPTSIGANRSRTPQQIAAQLAAGRSTPGEITATHTGVSRTQGSRPTTSKRSDDNEGPPLLAPKPVWATSANTASVNKLLRSEADLPIRDKSIQRRPVAQISPIEAARLAAKKPRPPPVPRKPAAVATGPTSVPINVHSKGPESPEPTSKNHSSRHLEDTTIPFKAPPALPPRTGASSVPRKDLTNHRRLLDTNHGSRRRPSTPGTASLYTTSLSNSTTSLLDSSSGLDEGALSDAVVASSRASVRASQERKVPPPPPPERRARSRSLKQFPHTAKGEHTDSSSPSTHLRQTLREPTKIAENDEGYQRHKHLIRKHPHKHHEGDRRRWRSEITEKERKRYEGVWAANKGLLLPPAHLRVPEAYPPESSEMVVNLVAADIWSRSRLPRHVLAQVWDLVDGQHIGLLTREEFVVGMWLIDQQLKGHKLPPRVPASVWGSAKRISGVHIHGLPPA

Gene
irs4
Protein
Increased rDNA silencing protein 4
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
501 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
54.359 kDa
Sequence
MAVHPEDKCAELPEPGSVRDKIGMFTAHSDDKRSLQPPSGRERGSVAASTSRSPQPAAGPGTTQRPPVPKKKPSLLADMGARPGFNQPRSQESCDSGTTDVLARKPVRSMTAGNGMPEGPQQTNKEMTIRSASIPARKPVPAPPSFGPPNTAQVPITRVRPSPPPPRKGGATPVSKITSLGEVKTGEISRSSQASANSKNGPAVGAEPRPKLPPRPEALSTSQSPLKSHRILLNEHDIRKGSMSPSSASTYSPLQQNGSSSSLLDQSSGLDEEALSNAIVASSLASAKALSTKKVPPPPPPQRQPRSRSILPLHSTKYDSPNDSSPTPSLRTTLRTPTKADEDQHDHHRHRKHIIPKHPHKHHEGDRKRWQSEVTEKERKRYEGVWAANKGYLIPISNPGNASSKQEDPRSAYPPSASEMVLNIVVRDIWSRSRLPAPILSQIWDLVDRQKIGLLTREEFVVGMWLIDQQLKGHKLPTKVPNSVWDSVRGVSGIKLPKFPV

Gene
IRS4
Protein
Increased rDNA silencing protein 4
Organism
Coccidioides immitis (strain RS)
Length
435 amino acids
Function
Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).
Similarity
Belongs to the IRS4 family.
Mass
47.532 kDa
Sequence
MKIPVTADAESASKDGLQHDDIRATATVRDRIKQFSAEASIPLEKASFSRQAPSQNPSITAKPPIPPQRAALKPGTKLVKATGTELCGNQQHGRSRNISPIAHFPAVPLSNKNTSAILSSDSETGAELADRREFTASKAVRHGSRDPHAEMSSWKSPTPLPQRKKEAPPVPPRSSQLSTESELLQLDPPSLHTDQEGSGVNHTLEVRESDISDSALADAMTASYLIPSHAALGSKRGLKQPPPPPPPRQRGSPSQPLLQLSSDSSKVNPPALGPDEILKRGMDMLDEPKSGSELPPKPPRRVTFNPNPEVFQIESGNVVQGQVISSERKRYEEVWEANRGVARFGVMHDPNVDQKVIRKSLAYEDLVVDLVVRDIWSRSRLPQAELAKIWKLVSHDAVGMLSREEFVVGMWLIDQCLKGHGLPTNVPKSVWKSVQ