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ipaJ

Gene
ipaJ
Protein
Cysteine protease IpaJ
Organism
Shigella flexneri
Length
259 amino acids
Function
Virulence factor that eliminates N-myristoyl protein modifications in infected host cells. Acts as a cysteine protease that cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3 of human ARF1, leading to the elimination of the myristoyl group and alteration of protein trafficking in host cell. Could also cleave an array of N-myristoylated host proteins involved in cellular growth, signal transduction, autophagasome maturation and organelle function.
Mass
28.807 kDa
Sequence
MSEQRKPCKRGCIHTGVMLYGVLLQGAIPREYMISHQTDVRVNENRVNEQGCFLARKQMYDNSCGAASLLCAAKELGVDKIPQYKGSMSEMTRKSSLDLDNRCERDLYLITSGNYNPRIHKDNIADAGYSMPDKIVMATRLLGLNAYVVEESNIFSQVISFIYPDARDLLIGMGCNIVHQRDVLSSNQRVLEAVAVSFIGVPVGLHWVLCRPDGSYMDPAVGENYSCFSTMELGARRSNSNFIGYTKIGISIVITNEAL