Function
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Plays a central role in convergent extension movements in gastrulating embryos, a processus regulated by Wnt signaling (By similarity).
Sequence
MSNPPQGSSLASPIQAAAVTGDKTTLLRLIASSPQVIDQEDQLGRTPLMYSVLGDRRSCAEALLKHGAKVNRPDRSGRTALHLAAQTGNHRLLKLLLSRKADCTHRDLCDITALHLSTRHQDTQCLVLLLKYTPPGQVDAQDQRKQTALHWSAYYNRPQHVRLLVRHGSNIGIPDTEGKIPLHWAAGHKDPEAALTVRCLFEAAPTESLLNWQDYEGRTPLHLAVGDGNQEVVRLLTSYRGCNVAPYDNLFRTPLHWAALLGHTPIAHLLLERNNSPNIPSDSQGATPLHYAAQGNCPDTVRVLLSHPSVRDEADLEGRTALMWAAGKGSDEVVRTMLELNPKLEVNRTDKYGGTALHAASLSGQITTVRILLENRAQADAVDVMKHTPLFRACEMGHREVIATLIKGGAKVHLVDKDGRSPLHWAALGGNANVCQILIENNINPDAQDYEGRTPLQCAAYGGYIGCMEVLMENKADPNIQDKNGRTALHWSCNNGYLDAVKLLLGYNAFPNQMENTEERYTPLDYALLGGHQEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGHKVRRAFQERKNLLMKHEQLRKGAAAKKREGENRQKVKVGQTKGKQKDADSMERQNKSNEQIIKNEVVHEWQGEASGNAEDRKGKHREENLETNHLQHSKHMAKNQRITAQIQSSPSEHEHTNSIQIRTSPSGTSNTQSSPLGNEIPKNMYWDDNPSQKHTQTRRTSRHQMESPDVVVHRIEDLIQKESRRKSHREERKGSHRQRQSSDYRLHTSEKEASDSAIHREEEGKKKETKKGRRTVAVTPKIEACCKGGCGKLSQSEKVSLGIGIQGRVDCITSPEPCETPSRVCRERKTISAKTGQRPLTETHKPPGKACRSSSALKSSLPSHIKQTAIDSKCLDSTLSYIGFGEAIKPLFPMGILREGSFFSKWQNIDIELIPVQARLQLVEREKARKQLFQRKNHAATVIQKAWRTYWVRKSSCKTRHSRSQNNPPAMV