ints4

Integrator complex subunit 4 homolog

1233 amino acids

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

Belongs to the Integrator subunit 4 family.

141.988 kDa

MNKKSHQQQVLQQQQQQQQQQFQQQHFQQQQQQQQFQQQQQQQQQLQQQQLQQQQQQQIQQQQQIQQQQQQQQQQQQQIQQQQQPQQIQQPQQQLPNFSVPIINQSIISNIKLYSTFETLLLSLSSTDTREQTKAIIYLSSLTINNKSNGIDLVYCIQKQLVVEAHNHIKVLLINLLGDISLDPFIDSFHILNKLLYLIRNEKSKKVLSSCLININKISKSLTFSKGNDVNSSSSSLINQIIEYIEPLLHSTSPLVRRETIVLLGSIVKNLDKESEEIQILLLNYLKDTDFRVREASLKSLSVIFQRGASLSVNKLYQSIILLLLDSFEQVRLECIKLIWIFGNIYPNHIVVSGGTKIRLVDDVFKKICNAVNDSSVIVRNCACKLLGCTYDVSLNYLIQTLSKEVMVWGKGKQYQIGHSSITKQRLQQKQQQQQQQQQQQQQQPPQQQPSQQPNQQPNQQQTNVSGTHIATPEGDFDVVGSDSLNILESGVIGAFIQGLEDEFYEVRSSAIDSMCELSVRNDEFAQKNIDFLVDIFNDEIESVRINSINSLRKIGNNVVIKEEQLHIILANLESSSKEERQSLHRLLTSIHLSNYSCLHATTQALLMNLSRYPYDIHSIFETLKIIGQTNPFTEFIVDDLLRIDPKFASVEPNMDDIFYVAVMVLVLNSCIKNRNILSLLPSFSFQHHLYFKDKYPKYFPQNLQKDSNIILAPTLKYSSVVNNNNNKNNNNNTTTTSIINDNGEINQFLNLTLSLLYGDNNNIINNNNTNNNNNNNNNNNNNNNNNNNNNNDENDENLNYGFQRLFLNQKKEIQLNKLFQECKRNFKRISSICLSLKPTSDFYNKYLKILTTIVSSSRRFKTITTSNQLNHLLYKLNHKFIGVDNNCKLILMEIGIYSFIIEILSTITLSTSSPPTTTTTTSSTSLFTSINSTPIELSNDQINQLTKKLNEYFKFSNDFKLEISTSIKSLLDLFNIKNNNINNNNNIINKKDKKLKENEENEENEENENNENENEKENGKNKEKEKNENDNENENENERPSKIQKTTSELIKTTTTTSTSTSTLIHYNLIEWTDNYIPPILKISNLIKKKSVDVILPIPNDKPIEFLDIFPLKLMINAKIENIRNLDSLFIQSTWQSIHTGQLNSQIHIIPKSAFTPTKPLSYNISCSIYLSLQNIRHNRLSSKESIPLRISIVEQFLNNNNNNNVTIIPLSKFVIFNILPVDNVNLLPNLI

IntS4

Integrator complex subunit 4

1022 amino acids

Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). Essential for development (PubMed:21078872). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).

Belongs to the Integrator subunit 4 family.

113.423 kDa

MALAIKKRVGTYVETVDGSPPVKKLRLQTLAADAKGGKSGKVGNVERKLTALNQLDAYVGNLPAGALVLPTGTPVASTGAPSTGVIGNPPAAATGAPPMTAANSRELLELLVKITDEISYEDVEMGELKEVASKIFQLYQLQERDSDTSIRVKLLELLSGLGCECATEQALTMIIDYFIFLLRKEVSQKVLAQGMMCLFRIGERRKHMLPISYKTQVAHLAKEQLRSGSAHTQKNAMLVIGRFATKMEGERHYVWKLAFYIDSQDSSVRAQALHALLTLGERGSQLPAVLYKRAVEAMKDDYECVRKEALQLVFMLGNRHPDYILPSDRQQEELRMIDAAFSKVCEALCDLSLQIRVLAAELLGGMTAVSREFLHQTLDKKLMSNLRRKRTAHERGARLVASGEWSSGKRWADDAPQEHLDAQSISIIASGACGALIHGLEDEFLEVRTAAVASMCKLALSRPDFAVTSLDFLVDMFNDEIEDVRLKAIYSLTAIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLMLGACRVSTQTCLLMVVQKLLDVLAKYPQDRNSTYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPERDVEDPAYLCVLILVFNAAEHLVPIISLLPTATHRHYAYLRDSMPNLVPQLPIEGASSASATHRIDSAMHQAGSSAEYLQMILSHIEEIFTMTDERLELLQTAQSNLQRLGSIDAGMYGTSNFLETFLAAQIQIEQMQRCASTQRSRVPLKESLAALIRNCLKLQHTFSGLNYGDILQVKQLRLRACALHLVLVVRDRSQSALGPCQMLLQTAGDISEFIKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLIKLDGISDPKPGRVFREILPLVQQAPPLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAAVPFVAEIDNLLESQKADMRIKIKYPDQHMHTVVPKQSDFKPIMTEQGEHKTNVRLRTTILLSHSVWTESSLVEIQLCLAVRPGSELELCKPAKVLFAPKPVRRGI

ints4

Integrator complex subunit 4

969 amino acids

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

Belongs to the Integrator subunit 4 family.

109.256 kDa

MAAHLKKRVYEEFTRVVQQQPLEEPSAKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDTSVRLKIASLLGLLSKTAGFCPDSIVDDVINTLQNEKSHQVLAQLLDTLLEIGLKLLDIVSHRMRLVDVACKHLSDTSHGVRNKCLQLLGCLGSVEASPAKEVENAVAKDVQKIIGDYFIDQDPRVRTAAIKAMLQLHERGLKLQQAMYNQACKLLTDDYEQVRSAAVELSWVLSQLYSESIVPIPSSNEEIRLVDDAFGKVCHMVSDGSWVVRVQACKLLGSMLQVSPHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEELDTGAVNLIDSGACGAFVHGLEDEMYEVRIAAVESLCLLARSSAPFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISDNITLREDQLDTVLAVLEDKSRDIREALHELLCCTNVSTKECIQLALVELLKNLSKYPTDRESIWKCLKFLGSRHPTLVLSLVPELLSTHPFFDTPEPDMDDPAYIAVLVLIFNAAKCCPTMPALFSDHTFRHYTYLRDSLSHLVPALNLPSVRWSWIPDVITEAPPEDPSQQFLQLSLERVHNLQHLGSQGTQELLEFTIRDLQRIGELQSDLAGMADFSATYLRCHLLLTKALNEKLWNLAAPLFLKNSLTTNAVKQILEETYKMEFMYSGLETRQVAIIHHMRLQAKALQLLVTARTTKGAEPLFGMCEEFLQEVDFFQRCFISELPHMQDSFVDKLLDLVPRLVNSKPLEMVKILQTTLRQCTFLRLTLPEQIHRASSHIIEPAEESDNPIRFTSGLVVALDVDATLEHVQEPQSTVKVQVVYPDGQVQIIHPKPADFRNPGPGRHRLITQVYLSHTAWTEPCQIEVRLLLAYSSSRSKVMSRASNSTWGESTETVPSTESSTEGTIPFSKPVKVFLMPKPARR

Ints4

Integrator complex subunit 4

964 amino acids

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.

Belongs to the Integrator subunit 4 family.

108.193 kDa

MAAHLKKRVYEEFTKVVQQQQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGSKLPENQATQVRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDTEGSAARDVQKIIGDHFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEIDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPALFSDHTLRHYAYLRDSLSHLVPALRLPGRKLVSSTVPSNITPHEDPSQQFLQQSLERVYSVQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLQCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIQHMRLQAKALQLIVTARTTRGVDPLFGMCEKFLQEVDFFQRCFIADLPHLQDSFVDKLLDLMPRLMASKPVEVIKILQTMLRQSTFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLLTQVYLSHTAWTEPCQVEVRLLLAYNSGARIPKSPWLEGSEMSPQVETSIEGTIPFSKPVKVYIMPKPARR

INTS4

Integrator complex subunit 4

963 amino acids

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

Belongs to the Integrator subunit 4 family.

108.171 kDa

MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKPARR