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inppl1a

Gene
inppl1a
Protein
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A
Organism
Danio rerio
Length
1266 amino acids
Function
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity).
Similarity
Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
Mass
140.371 kDa
Sequence
MAAVGPASPPPPPLWMHRDLSRAAAEELLARAGRDGSFLVRDSESVSGAYALCVLFQKHVHTYRILPDEENFLAVQTSQGVQPKRFKTLPELIQLYLQPSQGLVTTLLYPVEREETTEDRDYSDGEDEKPPLPPRTASTSSMTGSALVSTDTPPENVTAANGLSTISHEYLKGNYALDLEAVKQGANSLPHLNKTLLSSCKRLHGEVDKVLCGLEILSKVFDQQSASMVSRMIQQSMSQGGDQELEHLVTKLAILKDLLSSIEKKALKALQDMSSSTPAISPLLSIRNKVIPVQTFEVKLDVYLADLTKIGKSQKYSLSVDVEGGKLVVMKKMKDAQEDWNTFTHDKIRQLIKSQRVQNKLGIVFEKEKDKSQRKDFIFASAKKREAFCQLLQLMKNKHSNQDEPDMISIFIGTWNMGSVPAPKPLGSWILSRGLGKTLDEMAVTIPHDIYVFGTQENSVCDKEWVETLRCSLKEYTDMEYKPIAVQTLWNIKIVVLVKAEHENRISHVGMSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKIHRRNQNYLDILRQLSLGDKQLNSFDISLRFTHLFWFGDLNYRLDMDIQEILNYINRKEFDPLLKVDQLNLEREKNKIFLRFAEEEISYPPTYRYERGSRDTYVWQKQKATGMRTNVPSWCDRILWKSYPETHIVCNSYGCTDDIVTSDHSPVFGTFEVGVTSQFVSKKGLPKSSEQAYIEFENIEAIVKTASRTKFFIEFYSTCLEEFKKSYENDTQSSDNVNFLRVGWSSKQLTTLKPILSDIEYLQDQHLLLTVKSLDGYESYGECVLALKSMIGSTAQQFHTYLSHRGEETGNIRGSMRVRVPSERMGTRERLYEWISVDKDDMGGPKGRTLPPRTSHDYVKPTSSSSSRKHGSAELSRVSEEGEKSSTSRHTHTKEENTHNRGKQDPFESDATTCKNSFNNPAYYILEGVPNQSAALASDILPGSALPPLANKTTAPPAGSVGKSKPPSGSSAQGRWQTSGRSVRPISEEGSSEDDGNIGPHTGSLNRPPPDFPPPPLPKAALEMSENSFGKPRVFSDLADGKIPPPSKPLVSPGLTPPPGGAPGGGVAFCIESPPVLSPNSAPFRRGGGASALDDQSCSVLQMAKTLSEVEYPSGRERGASQGPTGPQLRGLSFPSHPIQEESIAEDLPEEGGLWGAESSSSSLSVDCSVGEWLQKLGLQHYEEGLLHNGWDDLEFLSDITEEDLEEAGVRDPAHKKILLASLKQQQK