Protein
N-demethylindolmycin N-methyltransferase
Organism
Streptomyces griseus
Function
Involved in the biosynthesis of the antibiotic indolmycin, an inhibitor of the bacterial tryptophan-tRNA synthetases. Catalyzes the methylation of N-demethylindolmycin to yield indolmycin, with S-adenosylmethionine (AdoMet) acting as the methyl donor.
Similarity
Belongs to the methyltransferase superfamily.
Sequence
MHTDWETSESAEDYSRNTAAAQWEPMGYPAVFRSLALATTDSDNAPPILDYGCGPGFVDRHVAEKYGRRVIAVDISSSMIDLARSQHSHPLVTYRHVPDSQLDFLGDKEIGGCMSCFVLMQMADSDTQVEICRRIRRTLAPGAMLAVLNTHPDSVGIQFATLRNGEPDRVYQPGDPMTTVLTTDKGVLRLQDYYWRVTDYVHALEAAGFHEVTVEHLPPPPADPTPHPQFLLVRGTA