Protein
Protein IMPACT homolog
Organism
Caenorhabditis elegans
Function
Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Similarity
Belongs to the IMPACT family.
Sequence
MSDEEQRIAEIESLASIFPDLLEETTDKQLVFKFDRDIGMTINLPEDYPSISPPIFELSGPYLRREQKEVLHNSLNDVYIENIGFPVIFNWISLVQDFIRDLPEEVAEPSHVADDVVTPMAEEIDDMNIRHGEVLTDRKSAFQAHLAEVRSKEDVDRVMRILKSNTKICRATHNITAYRYMTEINGKPIHHHDCVDDGEFGASSKMLELMDRMKADNVMVVVSRWYGGIHLGPDRFRHINNLTRQILSDNNYGPKKS