impA

Gene

impA

Protein

Immunomodulating metalloprotease

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Length

923 amino acids

Function

Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31.

Similarity

Belongs to the peptidase M88 family.

Mass

100.155 kDa

Sequence

MSLSTTAFPSLQGENMSRSPIPRHRALLAGFCLAGALSAQAATQEEILDAALVSGDSSQLTDSHLVALRLQQQVERIRQTRTQLLDGLYQNLSQAYDPGAASMWVLPANPDNTLPFLIGDKGRVLASLSLEAGGRGLAYGTNVLTQLSGTNAAHAPLLKRAVQWLVNGDPGAATAKDFKVSVVGVDKTAALNGLKSAGLQPADAACNALTDASCASTSKLLVLGNGASAASLSATVRARLQAGLPILFVHTNGWNQSSTGQQILAGLGLQEGPYGGNYWDKDRVPSSRTRTRSVELGGAYGQDPALVQQIVDGSWRTDYDWSKCTSYVGRTTCDDVPGLSDFSKRVDVLKGALDAYNQKAQNLFALPGTTSLRLWLLWADAVRQNIRYPMDKAADTARFQETFVADAIVGYVREAGAAQKELGSYAGQRQQSMPVSGSEETLTLTLPSAQGFTAIGRMAAPGKRLSIRIEDAGQASLAVGLNTQRIGSTRLWNTRQYDRPRFLKSPDIKLQANQSVALVSPYGGLLQLVYSGATPGQTVTVKVTGAASQPFLDIQPGEDSSQAIADFIQALDADKADWLEIRSGSVEVHAKVEKVRGSIDKDYGGDVQRFIRELNEVFIDDAYTLAGFAIPNQAKTPAIQQECAARGWDCDSETLHKLPGTQHINVDQYAQCGGGCSGNPYDQTWGLNPRGWGESHELGHNLQVNRLKVYGGRSGEISNQIFPLHKDWRVLREFGQNLDDTRVNYRNAYNLIVAGRAEADPLAGVYKRLWEDPGTYALNGERMAFYTQWVHYWADLKNDPLQGWDIWTLLYLHQRQVDKSDWDANKAALGYGTYAQRPGNSGDASSTDGNDNLLLGLSWLTQRDQRPTFALWGIRTSAAAQAQVAAYGFAEQPAFFYANNRTNEYSTVKLLDMSQGSPAWPFP

Protein

Immunomodulating metalloprotease: impA

Gene

impA

Protein

Immunomodulating metalloprotease

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

Length

923 amino acids

Function

Similarity

Belongs to the peptidase M88 family.

Mass

100.155 kDa

Sequence

Protein

Immunomodulating metalloprotease: impA

Gene

impA

Protein

Inositol-1-monophosphatase ImpA

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

276 amino acids

Function

Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria.

Similarity

Belongs to the inositol monophosphatase superfamily.

Mass

28.675 kDa

Sequence

MTVVGELDPQKLTALVATAAEILDAASVPFVAGHRADSAVRKQGNDFATEVDLAIERQVVRALTEATGIGVHGEEFGGEPIDSPLVWVLDPIDGTFNYAAGSPMAAILLGLLADGEPVAGLTWLPFTGEKYSALVGGPLYSDGKPCPPLGSPTLADSIIGIQTFNIDSRGRFPGRYRVEVLANLSRVCSRVRMHGATGVDLAYVAAGILGGAISFGHHIWDHAAGVALVRAAGGVVTDLTGAPWTVDSKSVLAAAPGVHEKMLEIVKSTGKPEDYL

Protein

Inositol-1-monophosphatase ImpA: impA

Gene

impA

Protein

Inositol-1-monophosphatase ImpA

Organism

Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

Length

276 amino acids

Function

Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria.

Similarity

Belongs to the inositol monophosphatase superfamily.

Mass

28.675 kDa

Sequence

Protein

Inositol-1-monophosphatase ImpA: impA

Gene

impA

Protein

Probable inositol 1-monophosphatase ImpA

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

270 amino acids

Function

Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria.

Similarity

Belongs to the inositol monophosphatase superfamily.

Mass

27.979 kDa

Sequence

MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINYAAGSPLAAILLGLLHDGVPVAGLTWMPFTDPRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADSRGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWTPASRSALAGPPRVHAQILEILGSIGEPEDY

Protein

Probable inositol 1-monophosphatase ImpA: impA

Gene

impA

Protein

Probable inositol 1-monophosphatase ImpA

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

270 amino acids

Function

Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria.

Similarity

Belongs to the inositol monophosphatase superfamily.

Mass

27.979 kDa

Sequence

Protein

Probable inositol 1-monophosphatase ImpA: impA

Gene

impA

Protein

Protein ImpA

Organism

Salmonella choleraesuis (strain SC-B67)

Length

145 amino acids

Function

Involved in UV protection and mutation.

Similarity

Belongs to the peptidase S24 family.

Mass

16.219 kDa

Sequence

MSTVYHRPADPSGDDSYVRPLFADRCQAGFPSPATDYAEQELDLNSYCISRPAATFFLRASGESMNQAGVQNGDLLVVDRAEKPQHGDIVIAEIDGEFTVKRLLLRPRPALEPVSDSPEFRTLYPENICIFGVVTHVIHRTRELR

Protein

Protein ImpA: impA

Gene

impA

Protein

Protein ImpA

Organism

Salmonella typhimurium

Length

145 amino acids

Function

Involved in UV protection and mutation.

Similarity

Belongs to the peptidase S24 family.

Mass

16.219 kDa

Sequence

MSTVYHRPADPSGDDSYVRPLFADRCQAGFPSPATDYAEQELDLNSYCISRPAATFFLRASGESMNQAGVQNGDLLVVDRAEKPQHGDIVIAEIDGEFTVKRLLLRPRPALEPVSDSPEFRTLYPENICIFGVVTHVIHRTRELR

Protein

Protein ImpA: impA

Gene

impA

Protein

Protein ImpA

Organism

Shigella flexneri

Length

145 amino acids

Function

Involved in UV protection and mutation.

Similarity

Belongs to the peptidase S24 family.

Mass

16.219 kDa

Sequence

MSTVYHRPADPSGDDSYVRPLFADRCQAGFPSPATDYAEQELDLNSYCISRPAATFFLRASGESMNQAGVQNGDLLVVDRAEKPQHGDIVIAEIDGEFTVKRLLLRPRPALEPVSDSPEFRTLYPENICIFGVVTHVIHRTRELR

Protein

Protein ImpA: impA

Gene

impA

Protein

Protein ImpA

Organism

Salmonella choleraesuis (strain SC-B67)

Length

145 amino acids

Function

Involved in UV protection and mutation.

Similarity

Belongs to the peptidase S24 family.

Mass

16.219 kDa

Sequence

MSTVYHRPADPSGDDSYVRPLFADRCQAGFPSPATDYAEQELDLNSYCISRPAATFFLRASGESMNQAGVQNGDLLVVDRAEKPQHGDIVIAEIDGEFTVKRLLLRPRPALEPVSDSPEFRTLYPENICIFGVVTHVIHRTRELR

Protein

Protein ImpA: impA

Gene

impA

Protein

Protein ImpA

Organism

Salmonella typhimurium

Length

145 amino acids

Function

Involved in UV protection and mutation.

Similarity

Belongs to the peptidase S24 family.

Mass

16.219 kDa

Sequence

MSTVYHRPADPSGDDSYVRPLFADRCQAGFPSPATDYAEQELDLNSYCISRPAATFFLRASGESMNQAGVQNGDLLVVDRAEKPQHGDIVIAEIDGEFTVKRLLLRPRPALEPVSDSPEFRTLYPENICIFGVVTHVIHRTRELR

Protein

Protein ImpA: impA

Gene

impA

Protein

Protein ImpA

Organism

Shigella flexneri

Length

145 amino acids

Function

Involved in UV protection and mutation.

Similarity

Belongs to the peptidase S24 family.

Mass

16.219 kDa

Sequence

MSTVYHRPADPSGDDSYVRPLFADRCQAGFPSPATDYAEQELDLNSYCISRPAATFFLRASGESMNQAGVQNGDLLVVDRAEKPQHGDIVIAEIDGEFTVKRLLLRPRPALEPVSDSPEFRTLYPENICIFGVVTHVIHRTRELR

Protein

Protein ImpA: impA