ima-1

Importin subunit alpha-1

524 amino acids

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).

Belongs to the importin alpha family.

59.925 kDa

MGDEFRPSHEERSKMYKSNVRDQNEMRRKRREDEVQIRKNRRDEKFERNRQITVQRSLSHEETSELLKSVADGLQSMQETTIHEALTVLHENLNNTVWTIHVLVKVQILHKLSDVYCNRVISQTTRLLISRTLLKISGIDEVKYERYSSDDRCIQSLVFNISTYGSSEDILCDTFQSIACFIIRSITYRNLALDCAIVSELIDASTINMSIILHRSLMWLVFLFCEKLDRCSPHVDEIAPLLEIISNGIQSTDAMVQTDAASSCASLAEWPPIYHYMSDLKLCSKLVANLRNDKGNARPKVKAGINSIIQATGYFTEEMIDAGLLEVLKGFVNVSYMSQEVCFIISNICVEGEQTIDKLISSGVLREVARVMEASEYRSRREAAFVICHCCASANQKHLEYVVELGMLSAFTDLLTCMDVSLVSYILDAIYLLLQFGEMRLLPDNSNPVAIKLEEIGCREKLEFLCESQSVDIHARAYTIIDRFYVDDDAPLNDDPFAGYQRNNIDDTIEKMIREPIMDQPFSF