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igf2bp3-b

Gene
igf2bp3-b
Protein
Insulin-like growth factor 2 mRNA-binding protein 3-B
Organism
Xenopus laevis
Length
593 amino acids
Function
RNA-binding protein that acts as a regulator of mRNA transport and localization. Mediates the specific association of Vg1 RNA to microtubules. May regulate mRNA translation (By similarity). Binds specifically to the vegetal localization elements (VLE or VgLE) in the 3'-UTR of Vg1 and VegT mRNAs. Binds to the Vg1 and VegT mRNAs in both the nucleus and the cytoplasm. Binds to the RNA sequence motif 5'-UUCAC-3'. May regulate mRNA translation (By similarity). Acts as a transcription regulator. Binds to the 5'-[TA]GGTTACT-3' motif within element 3 of the TFIIIA gene promoter. Binds DNA.
Similarity
Belongs to the RRM IMP/VICKZ family.
Mass
65.386 kDa
Sequence
MNKLYIGNLSENVSPPDLESLFKESKIPFTGQFLVKSGYAFVDCPDETWAMKAIDTLSGKVELHGKVIEVEHSVPKRQRSRKLQIRNIPPHLQWEVLDSLLAQYGTVENCEQVNTDSETAVVNVTYANKEHARQGLEKLNGYQLENYSLKVTYIPDEMATPQSPSQQLQQPQQQHPQGRRGFGQRGPARQGSPGAAARPKPQSEVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKPITIHSTPEGCSAACKIIMEIMQKEAQDTKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGSIETCAKAEEEVMKKIRESYENDIAAMNLQAHLIPGLNLNALGLFPPSSSGMPPPSAGVSSPTTSASYPPFGQQPESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPAEGPDAKLRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLEAHIKVPSYAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYASQLAQRKIQEILAQVRRQQQQQQKTAQSGQPQPRRK