IFT122

Intraflagellar transport protein 122 homolog

1241 amino acids

As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (PubMed:27932497, PubMed:29220510). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity).

141.825 kDa

MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP

ift122

Intraflagellar transport protein 122 homolog

1189 amino acids

Required for cilia formation during embryonal development. Acts as a negative regulator of Shh signaling.

136.443 kDa

MRAVPTWVDKVHDRDKLEQSIYDLAFKPDGTQLIVAAGNRVLVYDTSDGTMIQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSPEQKSVSKHKVSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGALSPIWSICWNPSKDDHNDILAVADWGQKLSFYQLSGKQVGKDRVLGFDPCCVSYFSKGEYIIVSGSDKQVSLFTKDGVRLGPIGEQNSWVWTCRVKPDSNYVVIGCQDGTLAFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKKIAIYKNRLAIQMPEKILIYELFSDDVNDMHYRVKEKIVKKFECNLLVVCSHHIILCQEKRLQCLSFKGVKEREWMMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNPFAITLLKQATSVRCLDMSASRNKLAVVDEHNTCLVYDITTKDLLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASNFPVHQQKLQGFVVGYNGSKIFCLHVYSMSAVEVPQSAPMYQYLERKMFREAYQIACLGVTDLDWKELAMEALEGLDFETAKKAFIRVRDLRYLELINSIEERKKRGDANDNLFLADVFAYQGKFHEAAKLYKKAGQESRALDMYTDLRMFEFAKEFLGSGDPKDTKTLITKQADWARNIREPRTAAEMYLSAGENMKAIELSGDHGWVDMLIEIARKLDKAEREPLLKCAYYFKKLQHHGYAAETYMKIGDLKALVRLYVETQRWEEAFALVEKNPEYKDEVYIPYAQWLAEHDRFEEAQKAFHKAGRQDEAVRVLEQLTHNAVVESRFNDAAYYYWMLSMQCLEISKDKEEKQDAMLQKFYHFQHLAELYHVYHSIHRYTDEPFSSHLPETLFNISRFLLHSLTKESPLGISKVNTLFTLAKQSKALGAYKLARQVYERLQGLRIPSRFLESIELGSITIRSKPFHDSEELIPMCYRCSTNNPFLNNLGNVCINCRQRFVFSASSYEVLPLVEFYLEDGISDEEAVSLVDLEAPRSSSKADSWREMSSGDTQTLRLDDGDDMMTYDPFTAKLSFEQGGSEFVPVVVNRAVLRTMSRRDVLIKRWPLPLKWQYFRSLLPDVSITMCPSCFQMFHTEDYELLVLQHNCCPYCRRPIEESSQ

ift122

Intraflagellar transport protein 122 homolog

1187 amino acids

Required for cilia formation during embryonal development. Acts as a negative regulator of Shh signaling.

135.765 kDa

MRAVPTWIDKVHDRDKVEQCIYDLAFRPDGSQLIVAAGNRVLVYDTADGTLIQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSGDFGLWSPEQKSVSKHKVSSKITCCGWTNDGQYLALGMMNGVVSIRNKNGEEKVKIERPGGSSSPVWSIAWNPSKDEHNDILAVADWGQKLSFYQLSGKQIGKDRSLTFDPCCVSFFSKGEYMVLCGSDRQAALYTRDGVRLGSIAEQNAWVWTCRVKPDSNYVVVGCQDGTIAFFQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKKIAIYRSRLAIQLPEKILIYELLSDDSADMHYRVKEKICRRFECNLLVVCSQHIILCQEKRLQCLSFTALRQREWLMESLIRYIKVIGGPAGREGLLVGLKNGAILKIFVDNPFPITLLKQNTSVRCLDMSSNRSRLAVVDEHNTCLVYDIHTRELLFQEPNANSVAWNTQCEDMLCFSGGGFLNIKACSFPVHQQKLQGFVVGYNGSRIFCLHVYSMAAVEVPQSAPMYQYLERRMFQQAYNIACLGVTDSDWRDLATEALEGLDFHTAKKAFIRIRDLRYLELISSIEERKKRGETDNQLFLADVFAYQGKFHEAAKLYRRSGQDGRALSMYTDLRMFDYAKDFLGSADPKDTKLLMKKQADWAKNSREPRAAAEMYLSAGEHLKAIQIIGEHGWVDMLIDVGRRLDKAERAALSRCAVFLQQLQQHGYAAELYSKMGDLRALLQLHVHATHWDEAFSLVEKHPQFRDDVYVPYAQWLAEHDRFEEAQRAFHKAGRQAEAVRVLEQLTHNAVVESRFSDASYYYWMLSMQCLDIAREDSEQKQEMLKKFHSFQHLAELYHVYHSVHRYMSEPFSSNMPEILFNISRFLFHNLSTHTPMGISKVDTLYALAKQSKLLGAYKVSRHAFEKLQSLKIPARYQDSVELSSLTVRSKPYRDNEDLIPMCYRCSTNNPLLNNQGNSCINCRQPFIFSASSYEVLPLVEFYLDQGISDEEAVSLIDLEVPRVEKNKSWQEMSSGESQCLKLEDGPDDPEDDPFTAKLSFEQGGSVFVPVRVSRAVLRSMSRRDVLIKRWPAPLSWQYYRSLLPDVSITMCPSCFQMFHSEDYELLVLQHSCCPFCRRPIDESC

Ift122

Intraflagellar transport protein 122 homolog

1182 amino acids

As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (By similarity). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (PubMed:19000668, PubMed:21209331).

134.798 kDa

MRAVLTWRDKAEQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMANGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREEHNDILAVADWGQKLSFYQLSGKQIGKDRPLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCRVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKKIAIYKNRLAIQLPEKILIYELYSEDSTDMHYRVKEKIVKKFECNLLVVCADHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFKEAYQIACLGVTDADWRELAMEALEGLEFETARKAFTRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNINEPKAAVEMYISAGEHAKAIEISGSHGWVDMLIDIARKLDKAEREPLLMCACYFKKLDSPGYAAETYLKIGDLKSLVQLYVDTKRWDEAFALGEKHPEFKDDVYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFNDAAYYYWMLSMQCLDMAQDPAQKDAMLDKFHHFQHLAELYHGYQTIHRYTEEPFSFDLPETLFNISKFLLHSLTKATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLRGLQIPARIQKSIELGTLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYEVLHLVEFYLEEGITDEEAVALIDLEAPRHKREGKWRETSSNNSQTLKLDETMDSIGEDDPFTAKLSFEQGSSEFVPVVVNRSVLRSMSRRDVLIKRWPPPLQWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHACCPYCRRRIDDTGP