Protein
Probable serine/threonine-protein kinase ifkA
Organism
Dictyostelium discoideum
Function
Phosphorylates eIF2-alpha, from 1 to 7 hours after the onset of development or during the preaggregation state, resulting in a shift from polysomes to free ribosomes for bulk mRNA.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Sequence
MAPGEIIIFELCQAVQEFLLLYNKETVSLHEEMIKRLNTNINRVNSSDDINNNNNNNNDDDDDNDDYDDSDDENSDSDYDDYDDSDDENSDDEFYSDDEDYNTRHQMGDIGSSVNKIINSIDHTISHGGGVGVGIGSGNGLFSKSSSSSSPMIPYNFSFDSLNGFDPDIIFEDSFQTPLKGSSSIDFEEMNNLTNSNNSNSTATTTTTTTTNNNNNNNTNNNNNNNSNNNNNNNNNNNNTNNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNISNNKINKINNNNNNKELIDNNNNNKDKENDLINDTIPKIKWKKGSCIERKSNYSVYRGVDEDTDRKLICKIVNLNIDDRSSSSLTSLSNSNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNLSIDVVELKKRLIEKVKMIQKEIESMKYLGNPYIIKYLGTNFQEGQNTLYIFQEYNSTLTLQQKILSNGIGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHNIFFNQSTSKMLLSNYGGRNIKIFDHFEKLNSLKNLNSWISSTNNSINNINNINNNNNNNNNNINTTTTQNQINNEIDRREDIINLGIVVLEMLCGSDLANNQTVLIYLAQLNLLNNQQQNQNFIQPPPLQYQLQQQYDLIKEIEQKTHPSSPISNNAKDFLSLCFTINGNGSTNDSLEAGILLKHPFLASNSNSTPPPSNFLNFTNNIKFLDQRSAATQALLSSPHSLIPQPIQTLIKSQTPNNNNDNNNLASSNELLSSSNGSNIDLRSTNSSIVSNPLATSSSLDNITPPPSRPISPKPSPLNKRNQKLQTSQQKPPLSPPQTPLKQIPQSPQSPPQQNFNTPPTTTTTTTTPTATPTTPTMTPLTPIQKQQQIDYDMFRYHSRYRTDFEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLREVTTLSRLHHQFVVRYYQAWIEKSCDSFQSLEEGNEDLSGDLETDASEDWFMQSSINSRSIISRDSYSGLSTSNSNVGGVNNTAGGGDSVSNANSNKSMIVGNSNKKLTLSSSNTSSSSSLLSNNKSKILNTSKSTSTNTSTSTSTSNTNKNKKISKKKKSKLSPLMKPKNKKNKNNGESEQSSSDSENGENGMKSRIIENASDSYSDDDNNNNNNNDNNNNYHSDNESDSFSGSISMSDGNGSGYEATDDEDIINNSGSFDENENDDDDEEDDDDEYDEEDDDYETFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNTANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQMERSNILRDLRDNLKFPPGFESTKPDQTQIIRSLLSRDPTQRPSTKQLLESGLLPSKMEDDILKEAIKTIANPTISLFSYLMEKLFCLSNDEHIMSRYLYTSNPSLTPMHLICREKTFSRLEKIFLNHGSIRIDTPTLFPKNPTNSTHPGAANVAKFLDESGTVVYLPYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKELYECDFDIIGPSKSRHISDAETLRIIIEIMEEFKDELFGNNSGSNSGSGSGGSINYKIRINHYGLLDSILSECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKEHGLSASIVSNISTYFRQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYYEGLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIVSGVGVTLACEKIVNSVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFVCSLGSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILREKAFQIGKLKVKQIETRQERTVARKDLVDFFLKSRKHNVDSKNIIQNTSSSDLSNLIGGINNSGSGGSGGSGGGSSMSSGGGGGGNSNIGGSDHHHHGHHSNQSTSSSGNSNNSNTQQTSPIQHHVHFSNTKSIIGSSGIISNATFSGGSSSSSNIIHFDEPTDSFSTQIVYQGVEEIKKSKIETLVQTSLSKLFRGFIQSKSSTIRVIVTDLAYSVIRDLQISESHDNISKFQRVSKEKLLQLKNQIFKWKVYPFIVIHSIKDDKSVIFNSVV