Protein
Eukaryotic translation initiation factor 4E-5
Organism
Caenorhabditis elegans
Function
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps.
Similarity
Belongs to the eukaryotic initiation factor 4E family.
Sequence
MTELTTPIYPLQRNWSWWFLNDDRNASWQDRLKKVYTFNTVPEFWAFYEAILPPSGLNDLCDYNVFRDDIQPKWEAPENWDGGRWLIIINKGKTPEVLDAVWLEILLALIGEQFGKDMESICGLVCNVRGQGSKISVWTKNCNDDDTNMRIGVVLKEKLMAAASKAHSKPLFDVIHYQTHRNCVKKTTSALKYKFSLKSIV