icmF

Fused isobutyryl-CoA mutase

1272 amino acids

Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry (PubMed:19864421). Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly (By similarity). Does not exhibit methylmalonyl-CoA mutase (MCM) activity (PubMed:19864421).

Belongs to the IcmF family.

137.407 kDa

MTDLSTPQRAGSHKLPAGRRLRFVTAAALFDGHDASINIMRRILQASGVEVIHLGHNRSVDEVATAALHEDADGVAVSSYQGGHNEYFRYLVDLLRARGGERIKVFGGGGGVIVPEEIAGLERYGVEKIYSPQDGQRLGLQGMIDDMIARCAEGARAAAATGESQVGAWAAEFSEHGLPRFDSRDDVGVDRQGAVARNPSSEASRVAAAGRGDHLDRGVRAASTADTADTANTANTANTANTGSVADAADAADAADAADAADAASTASTASTASTASTASTAGIPDPASLVFRRLAQLISAFETAAIDVNTRDKLSALAEVTAIPLLGITGTGGAGKSSLTDELIRRFRLDYGDALTIAVLAIDPSRRKSGGALLGDRIRMNAIGDWGGGARVYMRSMATREASSEISDSLPDALMLCKAAGFDLIVVETSGIGQGNAAIVPFVDESLYVMTPEFGAASQLEKIDMLDFASFVAINKFDRKGARDALRDVAKQVQRNRADFAKSPEAMPVFGTIASRFNDDGVTALYRHVAEALRKHGLRSGGGRLAAPEDLRFSSGRNAIVPPARVRYLADIAQTIHAYRERADAQARLARERWQLIEARRMLVETGEAARSTVATSASPGASASSKANACTSTSSKANASPGANTTANSNASATSGTATPTDALNPTLSQLDTLITQRTASLGERERILLDTWPEIVAAYSGTEHIVRVRDREIRTALTVATLSGSEVRKVSLPKFVDHGEILRWLMLDNLPGYFPFTAGVFPFRRENEDPTRMFAGEGDPQRTNRRFKLLSEGMPAKRLSTAFDSVTLYGEEPHERPDIYGKVGNSGVSVATLDDMKTLYDGFDLCAPETSVSMTINGPAPTILAMFFNVAIDQQIARTTQRQGRPLTEDELAATRRTALENVRGTVQADILKEDQGQNTCIFSTEFSLKVMGDIQAYFVEHGVRNFYSVSISGYHIAEAGANPISQLAYTLANGFTYVEAYLARGMSIDDFAPNLSFFFSNGMDPEYTVLGRVARRIWAVAMRERYGANERSQKLKYHVQTSGRSLHAQEIDFNDIRTTLQALIAIYDNCNSLHTNAFDEAITTPTEESVRRAVAIQLIINREWGLAKNQNPNQGSFVIEELTDLVEEAVLAEFDRLTERGGVLGAMETGYQRGRIQDESMLYEHRKHDGSYPIVGVNTFLSAHPHEAPQPIALARSTDDEKQSQLQRLRAFQAQHRDAAPAALERLKRAVIDDENVFAVLMDVVRVCSLGQITHALFEVGGQYRRNM

icmF

Fused isobutyryl-CoA mutase

1093 amino acids

Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, and to a much lesser extent, of pivalyl-CoA and isovaleryl-CoA, using radical chemistry (PubMed:22167181). Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly (PubMed:22167181, PubMed:25675500). The G-domain of IcmF has also a role in its cofactor repair (PubMed:28130442). Does not display ATPase activity.

Belongs to the IcmF family.

120.612 kDa

MTDLSDVSRTAAAKPPAVPGRGPANKVRFVTAASLFDGHDASINIMRRILQSQGCEVIHLGHNRSVQEVVTAALQEDVQGIAISSYQGGHVEYFKYMIDLLREHGGEHIQVFGGGGGVIVPDEIRELQAYGVARIYSPEDGQRMGLAGMITDMAQRCDIDLTRYAPTTLDTVVAGDRRALAQLITALENGKADPELVSALHAQAKAAAVPVLGITGTGGAGKSSLTDELIRRFRLDQDDALSIAVISIDPSRRKSGGALLGDRIRMNAINHPNIFMRSLATREAGSEISQALPDVIAACKAARFDLVIVETSGIGQGDAAIVPHVDLSLYVMTPEFGAASQLEKIDMLDFADFVAINKFDRKGAQDAWRDVAKQVQRNREQWHSRAEDMPVYGTQASRFNDDGVTMLYQGLVGALGARGMSLKPGTLPNLEGRISTGQNVIVPPARSRYLAELADTVRAYHRRVVAQSKLARERQQLRAAHDMLQGAGHESAALETLASERDVSLGAVERKLLAMWPQMQQAYSGDEYVVKIRDKEIRTGLISTTLSGTKIRKVVLPRFEDEGEILKWLMRENVPGSFPYTAGVFAFKREGEDPTRMFAGEGDAFRTNRRFKLVSEGMEAKRLSTAFDSVTLYGEDPHERPDIYGKVGNSGVSIATLEDMKVLYDGFDLTNPSTSVSMTINGPAPTILAMFMNTAIDQQIDRFRADNGRDPTADEEAKIRAWVLQNVRGTVQADILKEDQGQNTCIFSTEFSLKVMGDIQEYFVHHQVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTYVEAYLARGMHIDDFAPNLSFFFSNGMDPEYSVLGRVARRIWAVTMRDKYGANDRSQKLKYHIQTSGRSLHAQEIDFNDIRTTLQALIAIYDNCNSLHTNAYDEAITTPTAESVRRALAIQLIINREWGVAKCENPNQGSFLIEELTDLVEEAVLQEFERIAERGGVLGAMETGYQRGKIQEESLYYEQLKHDGTLPIIGVNTFRNPNGDPTPQTLELARSSEDEKQSQLHRLTEFHGAHQADAEAMLARLRQAVIDNRNVFAVLMDAVRVCSLGQITHALFEVGGQYRRNM

icmF

Fused isobutyryl-CoA mutase

1086 amino acids

Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, and to a lesser extent, of pivalyl-CoA and isovaleryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. Also displays ATPase activity. Is not able to convert 3-hydroxybutyryl-CoA to 2-hydroxyisobutyryl-CoA. Does not exhibit methylmalonyl-CoA mutase (MCM) activity.

Belongs to the IcmF family.

122.429 kDa

MAHIYRPKHHVRFVTASSLFDGHDASINIMRRILQASGAEVIHLGHNRSVEEIVNAAIQEDVQGIAVSSYQGGHMEFFKYMYDLLQERGASHIRIYGGGGGVIIPREIKELHEYGIARIFSPEDGRRLGLQGMINVMLEECDFPTVTVVTDELERLPSGDVQAIARLITLCEYRAEGENKEAAAAAEAAIEQVKALEKRVPVLGITGTGGAGKSSLTDELVRRFLNEIPDIKIAILSVDPTKQKTGGALLGDRIRMNSINSPRVYMRSLATRHSRTELSPAIRDAISVVKAAGFDLVIIETSGIGQGDAAITEVCDVSMYVMTSEFGAPTQLEKIDMIDYADLIVINKFERKGSEDAKRQVQKQYQRSHQLFDRDVSEMPVYGTIASQFNDPGTNTLFVALVDTINKKAGTNWKTSLKTVANVEKHNVIIPNERRYYLREIAETVRSYHRRAEQQVEVARRLFQIEGAIEAAKERGEAEDVIRALETLKADYEAKLTPESKRILATWEETKAKYAAKQFVTKVRDKEIVTELTTKTLSGLDIPKVVLPKFKDYGEILRWVYKENVPGSFPYTAGVFPFKRQGEDPKRQFAGEGTPERTNRRFHYLCKEDKAKRLSTAFDSVTLYGEDPDYRPDIFGKVGESGVSVCTLDDMKKLYKGFDLCDPLTSVSMTINGPAPILLAMFMNTAIDQQVEKKEAELGRPLTPEEYEQVKEWTLQTVRGTVQADILKEDQGQNTCIFSTDFALKMMGDIQEYFIKHRVRNYYSVSISGYHIAEAGANPITQLAFTLANGFTYVEYYLSRGMHIDDFAPNLSFFFSNGLDPEYSVIGRVARRIWAIVMREKYGANERSQKLKYHIQTSGRSLHAQEIDFNDIRTTLQALLAIYDNCNSLHTNAYDEAITTPTEESVRRAMAIQLIITKEFGLTKNENPLQGSFIIEELTDLVEEAVLQEFERLNDRGGVLGAMEMQYQRGKIQDESLYYETKKHTGELPIIGVNTFLNPNPPSEDELNNIQLARATYEEKETQIRNLREFQERNKDKAGPALERLKQVATSGGNIFEELMETVKVASLGQITRALYEVGGQYRRNM

icmF

Fused isobutyryl-CoA mutase

1071 amino acids

Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry (PubMed:19864421). Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly (By similarity). Does not exhibit methylmalonyl-CoA mutase (MCM) activity (PubMed:19864421).

Belongs to the IcmF family.

118.069 kDa

MADSTLHQPAYPVRFVTSAALFDGHDAAINIMRRILQSQGAEVIHLGHNRAVHEVVAAAVEEDVQGVAVSSYQGGHVEYFEYLASALRDAGAGHVRVFGGGGGVIVPEEIERLARSGVRIFSPEDGQRLGLPGMINELIQTCDVDLTGERPAVEAVLAGERTALARVITCLQQDALPAADRDALLAAARDRTVPVLGITGTGGSGKSSLTDELVRRLRTDQQDKLRVAILAVDPTRRRGGGALLGDRIRMNSLDGTHVFFRSLATRGGHELPHDIDAVIAACKAAGYDLVILETPGIGQGDAAIVDHVDVAMYVMTPEFGAASQLEKIDMLDFADVVAINKFERRGGADAVRDVSRQLLRNREAFGADPADMPVFGTSAATFNDDGVTALYQHLLELLGARGLPVDEGVLPRVQTRVSTRFAQIIPTARVRYLAEIADTVRTYHARTRDQVAAAQRVQRLELVAAELPGDAAVADLLARARAELDPENAALLARWPEVAESYRGPEQVVRVRDREIRTTLRRESLSGSSIPRVALPRFTDHGELLRFLRSENLPGHFPFTAGVFPFKRDNEDPARMFAGEGDPFRTNRRFKVLSEHSEAKRLSTAFDSVTLYGRDPDERPDIYGKVGTSGVSIATVDDMKALYDGFDLTAPTTSVSMTINGPAPTILAFFLNTAIDQALDRFRAAEGREPTADEAADLRARTLATVRGTVQADILKEDQGQNTCIFSTEFSLRMMADIQEWFVRNKVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTYVEAYLARGMHIDDFAPNLSFFFSNGMDPEYSVIGRVARRIWAIALRDKYGAAERSQKLKYHVQTSGRSLHAQEMNFNDIRTTLQALIAIYDNCNSLHTNAYDEAVTTPTEDSVRRALAIQLIINREWGLAMNENPLQGSFIIDELTDLAEEAVLTEFERISERGGVLGAMETGYQRGKIQDESMLYEHRKHDGSLPIIGVNTFRNPHGEPERTLELARATEREKQSQLDRVREFQRRHRTQAQAALARLEEVARTDENIFEVLMDAARVCSLQQVTETFFTVGGQYRRNV