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iclR

Gene
iclR
Protein
Transcriptional repressor IclR
Organism
Escherichia coli (strain K12)
Length
274 amino acids
Function
Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form.
Mass
29.739 kDa
Sequence
MVAPIPAKRGRKPAVATAPATGQVQSLTRGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFVRQVGELGHWAIGAHAFMVGSSFLQSRNLLAIVHPILRNLMEESGETVNMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCLAACIFDEHREPFAAISISGPISRITDDRVTEFGAMVIKAAKEVTLAYGGMR

Gene
iclR
Protein
Acetate operon repressor
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
274 amino acids
Function
Regulation of the glyoxylate bypass operon, which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase.
Mass
29.614 kDa
Sequence
MVAPVPAKRGRKPAATTAPVTGQVQSLTRGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFVRQVGELGHWAVGAHAFIVGSSFLQSRNLLAIVHPILRKLMEDSGETVNLAVLDQSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASGAGKAFLSQLSEEQVTSLLHRKGLHAYTHATLVSPLHLKDDLAQTRKRGYSFDDEEHALGLRCVASCIYDEHREPFAALSISGPCSRITDDRVTELGAMVIKAAKEVTLAYGGTR