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hypF

Gene
hypF
Protein
Carbamoyltransferase HypF
Organism
Azotobacter chroococcum mcd 1
Length
776 amino acids
Function
Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
Similarity
Belongs to the carbamoyltransferase HypF family.
Mass
82.569 kDa
Sequence
MNEAAKAGVRLLLRGRVQGVGMRPGVHRLATSLGLAGAVCNTGEGVRIDLQGPPAALAEFERRLPAELPPLARLDALQRENLPAGAHFAGFAIVPSRDEAGGALAPPPDAAVCPACLEELFDPHDRRWRHPFINCTHCGPRYSLIRRLPYDRAQTSLAGFALCPDCRHEYEDPADRRFHAQPIACPACGPRLWCEDAAGNRLPGEPVELALATLRRGEIVALRGVGGFHLACDARNAGAVALLRRRKRRPAKPFALMAANPASLEALVELNETGLNELSAPAAPVVLLRRRPAADGLLAAEVAPDLAWLGVMLPHSPLHWLLFHEAAGRPAGTAWTAAPQDLVLVMTSANLSGEPLITGNLEAREKLAGITDLWLLHDREILNRVDDSLVNALGRAPVVIRSGRGLAPQEIRLARSGPSVLALGGQLKNAICLTQGDRAWLSPHIGDLHSADACRSLERTVAQFGELLGVRPERIACDLHPDFFASRFAREHAERHGLPLYPVQHHHAHIAAVLAEHGLAEPVLGLALDGFGLGADGRLRGGELLKVAVDGCAWLGELNPLPLPGGDQAAREPWRMAAGALHALGRGGEIATRFAAEPGSAAIARMLERGFNCPPSSSAGRLFDAAAGLLGLGERQRYEAEAALRLESRIGSLPEAVPPLWRIGDDNRLDLSPLLARLADTHDSRVGAELFHAVLIAALTAWVVRAAAATGLRRIALGGGCFLNTVLRDGLCTRLQAAGLEPLLPRRAPVNDGGLALGQAWVVLLAPDIPSTRGQA

Gene
hypF
Protein
Carbamoyltransferase HypF
Organism
Azotobacter vinelandii
Length
776 amino acids
Function
Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
Similarity
Belongs to the carbamoyltransferase HypF family.
Mass
82.733 kDa
Sequence
MNQPAEAGVRLLLRGRVQGVGMRPCVHRLATSLGLAGEVRNTGAGVRIDLLGPPQALAEFERRLPDELPPLARLDAIQREPLPAGTRFAGFAIAASRDERRGALAPPPDAAVCPACLEELFDPHDRRWRHPFINCTHCGPRYSLIRRLPYDRVQTSLAGFELCPECRREYEDPADRRFHAQPIACPACGPRLCCEDASGRRLSGDPIERALAALARGEILALRGVGGFHLACDARNAGAVAELRRRKRRPAKPFALMAANPASLQALVELNENGLAELSGPAAPVVLLRKRPAADDLLAAGVAPDLAWLGAMLPHSPLHWLLFHEAAGRPAGTGWAAAPQDLLLVMTSANLSGAPPITGNAEARERLAGIADLWLLHDREILNRCDDSVVSALGRAPLVIRSGRGLAPLEIPLARGGPSILALGGQLKNAVCLTRGDRAWLSPHNGDLDDADTCRALERTVARLGELLGIRPERVACDLHPDFFASRFARDYAERHGLPLHPIQHHHAHIAATMAEHGLAEPVLGLALDGFGLGADGRLRGGELLRVAADGCAWLGELNPLPLPGGDQASREPWRMAAGALHALGRGGEIATRFAAEPGNAAIARMLERGFNCPPSSSAGRLFDAAAGLLGLGGRQRYEAEAALRLESRVVGLPERVPALWRIDDDNRLDLLPLLARLADMRDTRAGAELFHGVLIEALAIWAARAAEATGLHRVALGGGCFLNTVLRDGLCARLRAAGLTPLLARRAPLNDGGLALGQAWAVLLAADIPSTRGQA

Gene
hypF
Protein
Carbamoyltransferase HypF
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
767 amino acids
Function
Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
Similarity
Belongs to the carbamoyltransferase HypF family.
Mass
85.358 kDa
Sequence
MLKTVAIQVQGRVQGVGFRPFVYTLAQEMGLNGWVNNSTQGATVVITADEKAIADFTERLTKTLPPPGLIEQLAVEQLPLESFTNFTIRPSSDGPKTASILPDLSTCSACLTELFDPSDRRYLYPFINCTHCGPRYTIIEALPYDRCRTTMARFRQCTDCEREYKQPGDRRFHAQPNACPRCGPQLAFWNRQGQVIAEANEALNFAVDNLKVGNIIAIKGLGGFHLCCDATDFEAVEKLRLRKHRPDKPLAVMYGNLGQIVEHYQPNNLEVELLQSAAAPIVLLNKKKQLILVENIAPGNPRVGVMLAYTPLHHLLLKKLKKPMVATSGNLAGEQICIDNIDALTRLQNIADGFLVHDRPIVCPVDDSVVQIVAGKPLFLRRARGYAPQPITLPKPTQKKLLAMGGHYKNTVAIAKQNQAYVSQHLGDLNSAPTYQNFEEAIAHLSQLYDFSPQEIVADLHPDYFSHQYAENQALPVTFVQHHYAHILAVMAEHGVMEESVLGIAWDGTGYGMDGTIWGGEFLKITQGTWQRIAHLQPFHLLGNQQAIKYPHRIALALLWPTFGDDFSADSLGNWLNFNNGFKNKINSRLNQDLNNKNLRQLWQRGQAPLTSSMGRLFDGIATLIGLINEVTFEGQAAIALEAQIMPNLTEEYYPLTLNNKEKKLAVDWRPLIKAITTEDRSKTNLIATKFHNSLVNLIITIAQQQGIEKVALGGGCFQNCYLLASTITALKKAGFSPLWPRELPPNDGAICMGQLLAKIQARQYIC

Gene
hypF
Protein
Probable carbamoyltransferase HypF
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
766 amino acids
Function
Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
Similarity
Belongs to the carbamoyltransferase HypF family.
Mass
87.605 kDa
Sequence
MEILFFGVKMKVRIKVKGIVQGVGFRPFVYRIAKKNNLKGYVKNMGNYVEILIEGKKEDIRNFINDLKNKKPPLSRIDKLDIEEIKGIEEFDDFYIIKSENAKDEEEGTIPADVAICDDCLKEMLDKNDRRYRYPFIACTNCGPRFTIVEKLPYDRENTSMRDFPLCEKCLEEYKNPLDRRFHAQATCCPICGPKVFLSDGKEIIAEKDEAIRETVKLLEEGHILAIKGIGGTHLACKVGEDDVVLELRKRLGRPTQPFAVMSKIEYTELFAEFDEDEKNALLSLRRPIVVLKKSQDYDKYFSKYVSNLDTIGVMFPYSGLHYLLFDKEIAYVMTSANLPGLPMVKDNDEILKKLNGIADYFLLHNRRIVNRCDDSVVKKVADRLVFLRRSRGFAPEPVKVNINNNKNILCVGAELNSTACIVKRDKFYLTQYIGNTSKYETFCYLRDAINNILRLTNTNKIDAIVCDLHPQFNSTKLAEELSEKFGAEIFRVQHHFAHAYSLLGDNNYFDDAIILSLDGVGYGLDGNIWGGEVLLFKDGKMERVGHLEEQYQLGGDLATKYPLRMLLSILYKAIGEEAFDFIKRYNFFSEKELRLLKFQLEKKLNCPITTSTGRVLDAVSALLGICFEKTYDGEPSIRLEPVANRFKGDINIEPKIKNNILNTTELIYKSYEMLLNNENKEKIAHFAHIYIADGLFEIAKKISNKFGINTIGITGGVSYNKIITERIMNNAKREGFNFIYHQRVPNGDGGISFGQGVAYILKNGY

Gene
hypF
Protein
Carbamoyltransferase HypF
Organism
Rhizobium leguminosarum bv. viciae
Length
759 amino acids
Function
Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
Similarity
Belongs to the carbamoyltransferase HypF family.
Mass
80.73 kDa
Sequence
MTPSLARQIESPVRRLRLRVRGAVQGVGFRPFAYRLARAMRLSGFVLNDSAGVLIEIEGRDANHFPEAVRTQAPPLARIDSIDVLELVPAGGERFEILESLGGRSATRIGADAATCDGCRRELTDPASRFFGYPFVNCTHCGPRFTITRALPYDRAHTSMASFPMCRTCAADYVDPENRRFHAEPVACPNCGPRLSHPIKEISARLEGGAIVALKGVGGFHLLCDARNDGAIGLLRLRKAGDQKPFAVMVRDIEAARQLARPNEAEEALLISPARPIVLVAARAGELSGLIAPGLTRVGLMLAYAPVHHLLLDELSRSSPHCHAALVATSANPGGEPLVADNDDAGRRLVAIADLVVTHDRDIVVRADDSVMQVIDGAPAFIRRARGFVPEPVDLGADGPSVIATGADLKNTICVTRGREAFLSQHIGGLDNAEAIRFQREVIAHLCSILDVKPEFAACDLHPDFRSVRTAEGLNLPIVPVQHHLAHVAAVVADDRLSGPVLGLALDGHGFGTDGTSWGGEIVVIDHHRWQRAGSLMPLPLPSGDRAAREPWRMGVAALQAAGRIDLAPQLWPGHSGVTQLTAMFSGSMPTPVTSSLGRLFDAAAAIAGVRLVQDYEGQAAMEFEALVRAPRCLAGGYSIGDGTLDFRPLILHLAEQGRPCGADAADVFHGTLIAGLADWAARGAAARGTRQVALGGGCMMNRVLAAGLARALRERGLEPSLPRLAPANDGGIALGQPAYARQVIMNEHASIEENRTCA

Gene
hypF
Protein
Carbamoyltransferase HypF
Organism
Escherichia coli (strain K12)
Length
750 amino acids
Function
Involved in the maturation of [NiFe] hydrogenases (PubMed:8661925, PubMed:12377778, PubMed:12586941). Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases (PubMed:12586941). HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide (PubMed:12586941, PubMed:15291820). In the absence of any other substrate, displays carbamoyl-phosphate phosphatase activity (PubMed:12377778).
Similarity
Belongs to the carbamoyltransferase HypF family.
Mass
82.066 kDa
Sequence
MAKNTSCGVQLRIRGKVQGVGFRPFVWQLAQQLNLHGDVCNDGDGVEVRLREDPETFLVQLYQHCPPLARIDSVEREPFIWSQLPTEFTIRQSTGGTMNTQIVPDAATCPACLAEMNTPGERRYRYPFINCTHCGPRFTIIRAMPYDRPFTVMAAFPLCPACDKEYRDPLDRRFHAQPVACPECGPHLEWVSHGEHAEQEAALQAAIAQLKMGKIVAIKGIGGFHLACDARNSNAVATLRARKHRPAKPLAVMLPVADGLPDAARQLLTTPAAPIVLVDKKYVPELCDDIAPDLNEVGVMLPANPLQHLLLQELQCPLVMTSGNLSGKPPAISNEQALADLQGIADGFLIHNRDIVQRMDDSVVRESGEMLRRSRGYVPDALALPPGFKNVPPVLCLGADLKNTFCLVRGEQAVLSQHLGDLSDDGIQMQWREALRLMQNIYDFTPQYVVHDAHPGYVSSQWAREMNLPTQTVLHHHAHAAACLAEHQWPLDGGDVIALTLDGIGMGENGALWGGECLRVNYRECEHLGGLPAVALPGGDLAAKQPWRNLLAQCLRFVPEWQNYSETASVQQQNWSVLARAIERGINAPLASSCGRFFDAVAAALGCAPATLSYEGEAACALEALAASCHGVTHPVTMPRVDNQLDLATFWQQWLNWQAPVNQRAWAFHDALAQGFAALMREQATMRGITTLVFSGGVIHNRLLRARLAHYLADFTLLFPQSLPAGDGGLSLGQGVIAAARWLAGEVQNG

Gene
hypF
Protein
Carbamoyltransferase HypF
Organism
Rhodobacter capsulatus
Length
739 amino acids
Function
Involved in the maturation of [NiFe] hydrogenases (PubMed:9492269). Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide (By similarity).
Similarity
Belongs to the carbamoyltransferase HypF family.
Mass
77.879 kDa
Sequence
MQAWRIRVRGQVQGVGFRPFVWQLARARGLRGVVLNDAEGVLIRVAGDLGDFAAALRDQAPPLARVDAVEVTAAVCDDLPEGFQIAASGAAGAETRVTPDAATCPDCLAEIRGEGRRRGYAFTNCTHCGPRFSILQSLPYDRARTTMAPFAMCPACRAEYEDPADRRFHAQPIACPDCGPRLWLEAGGAELPGDAIGLAAARLKAGEILAVKGLGGFHLACDATNADAVDLLRARKRRPAKPFALMAREEDLARIVAVSPAALAALRDPAAPIVLMPARGSLPETLAPGMAELGVMLPYTPLHHLLLDAFGGVLVMTSGNLSGAPQVIGNDEAREKLSAFADAFLMHDRAIARRLDDSVVRVDPPMVLRRARGQVPGTLPLPPGFETAPQIVAYGGQMKAALCLIKTGQALLGHHLGELDEALTWEAFLQADADYAALFDHRPQAVAVDLHPDFRASRHGAARAGRLGVPLIAVQHHHAHLAACLGENLWPKDGGKVAVIVLDGLGLGPDGTVWGGELLLGDYKGFERVAWLKPAPLIGGDRAQIEPWRNALVRLDAAGLSDLADRLFPAAPRDLARQLAAKGINAPLSSSAGRLFDAVAACLGICPMRQSYEGEAAMRLESLAADTGPVPDLPCVGGAIDPAPLFQLLAAGERPDRVAHALHASLAQAFAAEARRLIEAGQAEAVALTGGCFQNSRLATMTRNFLADQGILTQGRIPANDGGLALGQALVAAAKLESN

Gene
hypF
Protein
4-hydroxyproline 2-epimerase
Organism
Paracoccus denitrificans (strain Pd 1222)
Length
334 amino acids
Function
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate, which would allow P.denitrificans to grow on t4LHyp as a sole carbon source (PubMed:24980702). Also seems to be involved in an alternative catabolic pathway that degrades trans-4-hydroxy-L-proline betaine (tHyp-B) to alpha-ketoglutarate; this pathway would permit the utilization of tHyp-B as a sole carbon and nitrogen source (PubMed:24056934).
Similarity
Belongs to the proline racemase family.
Mass
36.301 kDa
Sequence
MTQYIFPCIDGHTCGNPVRLVAGGAPRLEGATMLEKRAHFLREFDWIRTGLMFEPRGHDMMSGAILYPPTRGDCDVAVLYIETSGCLPMCGHGTIGTITMGIENGLIVPRTPGRLSIETPAGKVDIEYRQEGRHVEEVRLTNVPGFLYAEGLTAEVEGLGEIVVDVAYGGNFYAIVEPQKNFRDMADHTAGELIGWSLTLRAALNQKYEFTHPEHPQINGLSHIQWTGAPTVPGAHARNAVFYGDKAIDRSPCGTGTSARMAQLAARGRLGVGDEFWHESIIGSIFKGRIEAAATVAGRDAIIPSIAGWARQTGLNTIFIDAERDPFAHGFVVK