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htra1a

Gene
htra1a
Protein
Serine protease HTRA1A
Organism
Danio rerio
Length
479 amino acids
Function
Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity).
Similarity
Belongs to the peptidase S1C family.
Mass
51.441 kDa
Sequence
MILVTLFCICALVTSLQADARLSKRYVIGGCPSHCDKSMCPTMPKDCSTGQVMDHCNCCLVCASGEGEACGGVGKLGDPVCGESLECSVTGGVSYSATVRRRGKQGVCVCKSSDPVCGSDGVSYRDICELKRVSNRAQSLQQPPVLFIQRGACGTSLHDNPNSLRYKYNFIADVVEKIAPAVVHIELYRKMVYSKREMAVASGSGFVVSDDGLIVTNAHVVANKNRVKVELKNGASYDAKIKDVDEKADIALIKIDLPNKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESYDRLARGRGTTKKRYIGVRMMTLTPSLSKELKGRLRDFPDITSGAYVIEVISKTPAAAGGLKEHDVIISINGQRISTATDVSAIIKKESSLRVVVRRGNEDIILTIIPMEIDP