Protein
Glutathione-independent glyoxalase hsp3102
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (PubMed:24758716). May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity).
Similarity
Belongs to the peptidase C56 family. HSP31-like subfamily.
Sequence
MSIAKGKNALLVASSYYGPFYPDGKNTGVHFSELLIPYNVFKKAGFNVQFVSENGSYKFDDHSIEESKLGDFERKVFNDKNDDFWTNLNNMKKASDIVGKDYQLLFVAGGHAAMFDLPKATNLQAVAREVFTNGGVLSAVCHGPVLLANVKNPQSVEGKTVVYHKHVTAFNKAGEEKMGVMDELKKRGMKSLNEIFAEAGATFIDPPNPNVNFTQIDGKIVTGVNPQSAKSTAEAAVSAL