About Products Protein Database Contact

hprK

Gene
hprK
Protein
Putative HPr kinase/phosphorylase
Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Length
615 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
70.671 kDa
Sequence
MYTYTTIREIVDKLNLEILNEGNLDLKIDIPNIYQIGYELVGFLDKESDELNKYINICSLKESRFIATFSKERKEKVISEYMSLDFPALIFTKDAIITEEFYYYAKRYNKNILLSNEKASVTVRKIKFFLSKALSIEEEYENYSLMEIHGVGVLMSGYSNARKGVMIELIERGHRMVTDKNLIIRRVGENDLVGYNAKKREKLGHFYLEDIKGGYVDVTDHFGVKSTRIEKKINILIVLEEWNEKEFYDRLGLDVQYEDFVGEKIQKYIIPVRKGRNLAVIIETAALTFRLRRMGHNTPLEFLTKSQEIIERKKKEREEYMNTNRLPVTKLINEFDLEIKYGEDKVSSTYINSSNVYRPSLSLIGFFDLIEEVKNIGIQIFSKIEFKFLENLPPIERVNNLKKFLTYDIPMIVLTVDANPPDYFFDLVSKSGHILAIAPYKKASQIVANFNNYLDSFFSETTSVHGVLVELFGFGVLLTGKSGIGKSETALELIHRGHRLIADDMVKFYRNTQGDVVGKSAELPFFMEIRGLGIIDIKTLYGLSAVRLSKTLDMIIELQAVDNSDYMSAPSAHLYEDVLGKPIKKRILEISSGRNAAAMVEVMVMDHMSGLLGEK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Length
342 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
39.123 kDa
Sequence
MNFDQKGLKKRSITVAYFFEHIQKRFDIKFRRLNELDEQKCRIHERDLHRPGLAIAGFTKLFTYKRVQILGNTETRYLNHLSDEERKTAFANFVSFRMPCIILTSNNKLDQELVDMATGAGIPVFITRCSSTKTIYYITDFLDEEFSLYQQYHGSMIDVYGVGVLLTGKSGLGKSEVALDLIERGHGLVADDVVVVKRKGETKTLVASRNNIIDHFMEIRGLGVVDVRQNFGIRAIRDRKEVQVVVELLEWSKESEYERLGLDQKMVKLLGVDLPLVQLPIFPGKNITAIIEVVALNFLLKHYAGYVPAEALTERIRNVINKERAKAPAPSTSFEEYNDEND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chloroherpeton thalassium (strain ATCC 35110 / GB-78)
Length
340 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
39.147 kDa
Sequence
MDFKKKPIKKKSITVAYFYEHLSSRLSIKLKKLNQVDEEKRKIYERDIHRPGLALAGFTNLFTYRRVQVFGNTETWFLNHLGTEERKQAFSNITRYKVPCIIVTNNNKLDPELVEMATEAGIPLYRTSHTTTKFIYLITDFLDDQFCHYQHYHGSMVDVYGVGMFITGRSGIGKSEVALDLIERGHRLVADDLVVITRKGESVLMASGTELVRHFMEIRGLGIIDVEAMFGIRAIRHQKRVEIVVELLEFEPGKEFDRTGLENKSVDILGVEVPLVQLPIYPGKNITVIAEVVALNYLLKHYGYDAAEEFDRRIQQQIATRATVNNPAQRAVEYFEHDFE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Prosthecochloris aestuarii (strain DSM 271 / SK 413)
Length
340 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
38.67 kDa
Sequence
MNLDQKGLKKRSMTVAYFFENISKSLDIKLRRLNEVDEQKRRIFERDLHRPGLALAGFTNLFTYKRVQILGNTETRFLNHLEDDDRKRAFESLIKFKLPCIILTSNNKLEPELLDMATRAGVPVFVTRHSSTKTIYLLTDFLDDQFSQYQQFHGSMVDVYGVGVMLIGNSGLGKSEVALDLVERGHRLVADDAVVINRKGENVLIASGNEIVDHFMEIRGLGVVDVKAIFGIRAIRDKKVVQVVVELLEWNEESDYERLGLDTKTTKILGVDIPLIQLPINPGKNITVIIEVVALNYLLKHYSGYVAAEALEQRIKRVITNESLKKSGKGRTYLAKDYEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chlorobium phaeobacteroides (strain BS1)
Length
339 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
38.432 kDa
Sequence
MKFDQKGLKKQSMTVAYFFDNINNDLDIKLRRLNEVDEQKRRITDRDLHRPGLALAGFTNLFTYKRVQILGNTEMRFLNHLDDKTRKMAFENIVKYKVPCIIITSNNKLDPALLDMATEAGIPAFITRNSSTRTIFLITDFLVDRFSVYQQYHGSMVDVYGVGVMLVGKSGLGKSEVALDLVERGHRLVADDAVVINRKGEKTLIASGNHVIGHFMEIRGLGVVDVKAAFGIRAIREKKVVQVVVELMEWNEDMDYERLGLDTKTTKILGVEVPLIQLPINPGKNITVIIEVVALNYLLKQYSGYVAAEALEERIKTSIDDEAMMTTRFGSNYLTKDYE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chlorobium luteolum (strain DSM 273 / 2530)
Length
332 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
37.602 kDa
Sequence
MTLDQKGLKKRSVTVAYFFNNIGKKHDIRLRRMNTVDEQERRIFERDLHRPGLALAGFTNLFTYKRLQILGNTETRFLNHLGEEERKAAFANLTRFKVPCIILTSNNKLQPELLDMATAAGIPVYVTRQSSTKAIYLVTDFLDDQFSLYQQYHGSMVDVYGVGVLLTGKSGLGKSEIALDLVERGHGLVADDVVVIRRKGETMQLSASRNNIIDHFMEIRGLGVVDVKANFGIRAIRDVKEVLVVVELLEWNKEMEYERLGLDTKTIRILGVDVPLVQLPIFPGKNITVIIEVVALNFLLKRYSNYVAAEALTDRIKKVIHNDDRTAGDILV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chlorobium phaeovibrioides (strain DSM 265 / 1930)
Length
332 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
37.671 kDa
Sequence
MSLDQKGLKKRSVTVAYFFENIGTTHDIKLRRLNSVDEQKRRIFERDLHRPGLALSGFTNLFTYKRVQILGNTETRFLNHLGEEERRQAFDNLVRFKVPCIILTSNNKLQPDLLEMATEQGIPVFVTRHSSTKAIYQVTDFLDDQFSLYQQYHGSMVDVYGVGVLLIGKSGLGKSEIALDLVERGHGLVADDVVVIRRKGESMQLSASRNNIIDHFMEIRGLGVVDVKANFGIRAIRDVKEVLVVAELLEWNKEMEYERLGLDTKSTKVLGVDVPLVQLPIFPGKNITVIIEVVALNVLLKRYSNYVAAEALTDRIKQVIKNDERTEGEIVL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)
Length
331 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
37.846 kDa
Sequence
MNLDQKGLKKRSITVAYFFNTIGKKNDIKFRRLNEVDEQKRRIFERDLHRPGLALAGFTNLFTYKRVQILGNTETRFLNHLEEEERNRVFANLVRFKMPCIILTSNNKLPQNLLDMATNADIPVYVTRCSSTKTIYIVTGFLDDQFSLYQQYHGSMVDVYGVGVLLTGKSGLGKSEIALDLVERGHGLVADDVVVIHRKGESMVLNAKRNNIIDHFMEIRGLGVVDVRANFGIRAIRDVKEVQVVVELLEWNKEIVYERLGLDIKSRKILGVDVPLVELPIFPGKNITVIIEVVALNFLLKRYSNYVAAEALTDRINDVINREKGEEDSYE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330)
Length
330 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
37.601 kDa
Sequence
MNFDQKGMKKRSITVAYFFENIGRNHDIKLRRLNRVDEQKRRISERELHRPGLALAGFTNLFTYKRVQILGNTETRFLNNHDEAERRKAFENLVRFKVPCIILTSTNKLQPELLEMATEAGVPVYATRHSSTKAMYLITDFLDDQFSLHQQYHGSMVDVCGVGVLLTGKSGLGKSEIALDLIERGHGLVADDVVIIRRKGESLVLNARRNDIIDHFMEIRGLGVVDVKANFGIRAIRDIKDVQVVVELLEWNRETDYERLGLDMKSIKILGVEVPLVQLPIFPGKNIAVIIEVVALNFLLKHYSNYVAAEALTERIRTSIDKGNEQDDES

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)
Length
325 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.306 kDa
Sequence
MKPTVISADALFDAHRAALKWEWIAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLQPGDASGDNPVELQEKRISRIVTLEPPVLVVADGCTPPDRLVAMCERADIPLFCTEDSAGHVIDVLRGYLSQHFAERTSRHGVFMDILGLGVLLTGESGLGKSELGLELISRGHGLVADDVVDLFRVSQAAIEGRCPELLRNLLEVRGIGLLDIRAIFGETAVRRKMRLKLIVHLVRKETLDRDFERLPYEPLFEDILGMPVRKVVIAVDAGRNLAVLVEAAVRNTVLQLRGIDTYRDFIQRHRDLMDSGDSGL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)
Length
325 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.306 kDa
Sequence
MKPTVISADALFDAHRAALKWEWIAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLQPGDASGDNPVELQEKRISRIVTLEPPVLVVADGCTPPDRLVAMCERADIPLFCTEDSAGHVIDVLRGYLSQHFAERTSRHGVFMDILGLGVLLTGESGLGKSELGLELISRGHGLVADDVVDLFRVSQAAIEGRCPELLRNLLEVRGIGLLDIRAIFGETAVRRKMRLKLIVHLVRKETLDRDFERLPYEPLFEDILGMPVRKVVIAVDAGRNLAVLVEAAVRNTVLQLRGIDTYRDFIQRHRDLMDSGDSGL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Ralstonia pickettii (strain 12J)
Length
324 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.678 kDa
Sequence
MELTGVIAQSIFDDNAADLKLSWVAGLEGADRAFDVDFAKEATSAADLVGHLNLIHPNRIQVLGKPEITYYQRLSEENRKRQMGELILLEPPFLVVADGVDPPPDLELRCTRSSTPLFTSPISSAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKIKLIVQLVRRNDGEFERLPLDSQYLDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRDFMDRQRAAMQAEAASHSPQGRLL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Ralstonia solanacearum (strain GMI1000)
Length
324 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.684 kDa
Sequence
MELTGVTAQSIFDDNAADLKLSWVAGLEGADRAFDVDFAKEATSAADLVGHLNLIHPNRIQVLGKPEITYYQRLSEENRKRQMGELILLEPPFLVVADGVDPPPDLELRCTRSSTPLFTSPISSAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKIKLIVQLVRRNDGEFERLPLDSQYMDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRDFMDRQRAAMQAEAASHSPQGRLL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)
Length
323 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.714 kDa
Sequence
MELTGVTSQSIFDDNAADIKLSWVAGLEGADRAFDVEFAREATSAADLVGHLNLIHPNRIQVLGKPEILYYQRLDDEPRKRQMGELILLEPPFLVVADGMEPPPDLELRCTRSSTPLFTTPVSSAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGESGLGKSELGLELISRGHGLVADDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLVVQLVRRNDGEFERLPLDSQYLDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRDFMDRQRAAMQADVVSRGQGRLL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
Length
323 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.691 kDa
Sequence
MELTGVTSQSIFDDNAADIKLSWVAGLEGADRAFDVEFAREATSAADLVGHLNLIHPNRIQVLGKPEITYYQRLDDETRKRQMGELILLEPPFLVIADGMEPPPDLELRCTRSSTPLFTTPVSSAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGESGLGKSELGLELISRGHGLVADDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKIKLVVQLVRRNDGEFERLPLDSQYLDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRDFMDRQRAAMQADAVSRGQGRLL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Cupriavidus necator (strain JMP 134 / LMG 1197)
Length
323 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.695 kDa
Sequence
MELTGVTSQSIFDDNAADIKLSWVAGLEGADRAFDVEFAREATSAADLVGHLNLIHPNRIQVLGKPEITYYQRLDDETRKRQMGELILLEPPFLVVADGMEPPPDLELRCTRSSTPLFTTPVSSAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGESGLGKSELGLELISRGHGLVADDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKMKLVVQLVRRNDGEFERLPLDSQYLDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRDFMDRQRAAMQADAVSRGQGRLL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)
Length
323 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.691 kDa
Sequence
MELTGVTSQSIFDDNAADLKLSWVAGLEGADRAFDVEFAREATSAADLVGHLNLIHPNRIQVLGKPEITYYQRLDDETRKRQMGELILLEPPFLVIADGMEPPPDLELRCTRSSTPLFTTPVSSAAVIDHLRLYLSRISAPRVTMHGVFLDILGMGVLIMGESGLGKSELGLELISRGHGLVADDAVDFVRLGPDFIEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKIKLVVQLVRRNDGEFERLPLDSQYLDVLGLPIHMVKIQVAAGRNLAVLVEAAVRNTILRLRGIDTLRDFMDRQRAAMQADAVSRGQGRLL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Length
323 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.084 kDa
Sequence
MSQVSITQLFEENQEKLNLQWGEPSAVIDRQLENHQINNSTQELIGHLNFVHPNWIQVLNQTSVNYLDQLDDVSLKKRLNQLAKSQLACLIVADDAPIPNAIRQFVNEQSVPLIQSATASLEIIWRLQSYLARMLAPAITRHGVLLDVLGMGVMITGESGVGKSELALELISRGHGLVADDVVELHRIGPETLEGQCPPLLRDFLEVRGLGMLNIRTIFGETAVRRRKNMKLIVHLEKTVGSSINAYERLPLSNLNEIILNVGIRKVIIPVAAGRNLAVLVEAAVRNYILQLRGIDSTQEFIRRHESEMAGNTAEHFDDSHNE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chlorobium phaeobacteroides (strain DSM 266)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.737 kDa
Sequence
MTLEQKGLKKQSITVAYFFDTIGKEHDIKLRRLNSVDEQKRRIFERDLHRPGLALAGFTNLFTYKRVQILGNTEMRFLNQHEEDARKNAFGNFVRFKIPCIILTSTNKLQPELLAMATEAGIPVFSTRHSSTKTMYLITEFLDNQFSLYQQYHGSMVDVYGVGVLLKGRSGLGKSEVALDLVERGHGLVADDVVVIHRKGESMILTAKRNKNIEHFMEIRGLGVVDVKANFGIRAIRDAKEVQVVVELLEWNKEMEYERLGLDTKTTKILGVEVPLVQLPIFPGKNITVIIEVVALNFLLKHYYDYVPAEALTKRIRTAIDQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.306 kDa
Sequence
MPVPGITVETILRDHDDLQLQLVTGEVGLSNRINSAEINRPGLSLTGFFDFFANDRIQILGKGEWAYLNSLSEEKLGEITDKFFEFHLNCIIYTHGNEPQVPFVERAKEKGIPLFKTEIATHRFITLISQILDRALAPRTMRHGVLIEVFGIGTLLTGRSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGSCSDLLRHHMEIRGLGILNIKDLFGVGSVRDHKLIELIINLKEWEEQTSGDYERTGIEQSMEEILGVSVPYIEIPVKPGRNIPIIVETAAMNQRLRKMGKNSAKEFSNKLNTYIQQSSIETNPIKD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.306 kDa
Sequence
MPVPGITVETILRDHDDLQLQLVTGEVGLSNRINSAEINRPGLSLTGFFDFFANDRIQILGKGEWAYLNSLSEEKLGEITDKFFEFHLNCIIYTHGNEPQVPFVERAKEKGIPLFKTEIATHRFITLISQILDRALAPRTMRHGVLIEVFGIGTLLTGRSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGSCSDLLRHHMEIRGLGILNIKDLFGVGSVRDHKLIELIINLKEWEEQTSGDYERTGIEQSMEEILGVSVPYIEIPVKPGRNIPIIVETAAMNQRLRKMGKNSAKEFSNKLNTYIQQSSIETNPIKD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.306 kDa
Sequence
MPVPGITVETILRDHDDLQLQLVTGEVGLSNRINSAEINRPGLSLTGFFDFFANDRIQILGKGEWAYLNSLSEEKLGEITDKFFEFHLNCIIYTHGNEPQVPFVERAKEKGIPLFKTEIATHRFITLISQILDRALAPRTMRHGVLIEVFGIGTLLTGRSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGSCSDLLRHHMEIRGLGILNIKDLFGVGSVRDHKLIELIINLKEWEEQTSGDYERTGIEQSMEEILGVSVPYIEIPVKPGRNIPIIVETAAMNQRLRKMGKNSAKEFSNKLNTYIQQSSIETNPIKD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.306 kDa
Sequence
MPVPGITVETILRDHDDLQLQLVTGEVGLSNRINSAEINRPGLSLTGFFDFFANDRIQILGKGEWAYLNSLSEEKLGEITDKFFEFHLNCIIYTHGNEPQVPFVERAKEKGIPLFKTEIATHRFITLISQILDRALAPRTMRHGVLIEVFGIGTLLTGRSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGSCSDLLRHHMEIRGLGILNIKDLFGVGSVRDHKLIELIINLKEWEEQTSGDYERTGIEQSMEEILGVSVPYIEIPVKPGRNIPIIVETAAMNQRLRKMGKNSAKEFSNKLNTYIQQSSIETNPIKD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
36.214 kDa
Sequence
MADEVKLSKLIKDNKSILEVYQGQEYVNAKKIYVSDIYRPGLELTGYFDFYPAQRIQLLGRTEISYAARLDHEIRTHVFTKMATKATPCFLISRSLPVPEELSEAAEKANIPILRTSESTTYISSILTEYLRARLAKRNSIHGVLVEIKGMGVLLTGASGVGKSETALGLVQRGHRLIADDRVDVFQKDHNTVVGEAPKILRHLMEIRGIGIIDVMNLFGAGAVKSRTEIQLVINLVNWDPKANYDRLGFQENTREICNVEIPQVNIPVKVGRNIEIIIEVAAMNFRAKKMGYDATQMFDNNLTNLISEHSKEDTDKVQHDD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus helveticus (strain DPC 4571)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.956 kDa
Sequence
MADAVKLSNLIKDNKSILEVYQGHEYIKDDKIYVSDIYRPGLELTGYFDFYPAQRIQLLGRTEISYAARLDHDIRMHVFNKMATKATPCFLISRSLPVPKELSEAAEEADIPILRTGESTTYISSILTEYLRARLAKRTSIHGVLVEIKGMGVLLTGASGVGKSETALGLVQRGHRLIADDRVDAFQKDHNTVVGEAPKILRHLMEVRGIGIIDVMNLFGAGAVKSRTEIQLVINLVNWDPKANYDRLGFEENTCTLCNVPIPQVNIPVKVGRNIESIIEVAAMNFRAKQMGYDATQTFDNNLTSLISEHSKEDTNKEPHND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia cenocepacia (strain AU 1054)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.121 kDa
Sequence
MDTSSINAQSIFDDNAATLKLSWLTGHEGWERGFSADTVGNATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia cenocepacia (strain HI2424)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.121 kDa
Sequence
MDTSSINAQSIFDDNAATLKLSWLTGHEGWERGFSADTVGNATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.121 kDa
Sequence
MDTSSINAQSIFDDNAATLKLSWLTGHEGWERGFSADTVGNATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.151 kDa
Sequence
MDTSSINAQSIFDDNAATLKLSWLTGHEGWERGFSSDTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.121 kDa
Sequence
MDTSSINAQSIFDDNAATLKLSWLTGHEGWERGFSADTVGNATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFIDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.149 kDa
Sequence
MDTSSINAQSIFDDNAATLKLSWLTGHEGWERGFSADTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPESQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia mallei (strain NCTC 10247)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.165 kDa
Sequence
MDTSSINAQSIFDDNAAMLKLSWLTGHEGWERGFSADTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia mallei (strain NCTC 10229)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.165 kDa
Sequence
MDTSSINAQSIFDDNAAMLKLSWLTGHEGWERGFSADTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Burkholderia mallei (strain ATCC 23344)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.165 kDa
Sequence
MDTSSINAQSIFDDNAAMLKLSWLTGHEGWERGFSADTVANATSSADLVGHLNLIHPNRIQVLGEAEIDYYQRQTDEDRSRHMAELIALEPPFLVVAGGAAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLV

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.147 kDa
Sequence
MDTSSINAQSIFDDNAAALKLSWLTGHEGWERGFSAETVATATSSADLVGHLNLIHPNRIQVLGEAETNYYQRQSDEDRSRHMAELIALEPPFLVVAGGVAAPPELVLRCTRSSTPLFTTPMSPAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.209 kDa
Sequence
MDTSSINAQSIFDDNAAMLKLSWLTGHEGWERGFSSESVANATSSADLVGHLNLIHPNRIQVLGDAEIDYYKRQTDEDRSRHMAELIALEPPFLVVAGGVAAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Paraburkholderia xenovorans (strain LB400)
Length
322 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.205 kDa
Sequence
MDTSSINAQSIFDDNAATLKLSWLTGHEGWERGFSSESVANATSSADLVGHLNLIHPNRIQVLGDAEIDYYKRQTDEDRSRHMAELIALEPPFLVVAGGVPAPPELVLRCTRSSTPLFTTPMSAAAVIDSLRLYMSRILAPRATLHGVFLDILGMGVLLTGDSGLGKSELGLELISRGHGLVADDAVDFVRLGPDFVEGRCPPLLQNLLEVRGLGLLDIKTIFGETAVRRKMKLKLIVQLVRRPDGEFQRLPLESQTVDVLGLPISKVTIQVAAGRNLAVLVEAAVRNTILQLRGIDTLRDFMDRQRLAMQDPDSQFPGKLI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Length
321 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.119 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGQKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRTPEDLEKIAAEFFGFHLNCIIFTHGNMPPPIFMENCEKLGIPLMISEVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIHLEEWTEGKDFDRTGLENPTEELLGVQIPLIRVPVRPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSQYLQQGKVERNPTQNQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Length
321 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.119 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGQKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRTPEDLEKIAAEFFGFHLNCIIFTHGNMPPPIFMENCEKLGIPLMISEVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIHLEEWTEGKDFDRTGLENPTEELLGVQIPLIRVPVRPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSQYLQQGKVERNPTQNQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Length
321 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.119 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGQKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRTPEDLEKIAAEFFGFHLNCIIFTHGNMPPPIFMENCEKLGIPLMISEVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIHLEEWTEGKDFDRTGLENPTEELLGVQIPLIRVPVRPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSQYLQQGKVERNPTQNQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Length
321 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
36.119 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGQKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRTPEDLEKIAAEFFGFHLNCIIFTHGNMPPPIFMENCEKLGIPLMISEVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIHLEEWTEGKDFDRTGLENPTEELLGVQIPLIRVPVRPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSQYLQQGKVERNPTQNQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus reuteri (strain DSM 20016)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.488 kDa
Sequence
MPNNVTVQELVDKVRLKVLQGEDYLQRKITTSDISRPALEFAGYFKHYPAARIQLLGITETSFAKDLTHEQREEYMTKMCMPQTPCFVISTNLPIPKELKKAAEDAKIPILGTHLTSSQILSNMTSYLLERLAPRKSLHGVLVDISGVGVLITGDSGVGKSETALELVRRGHRLIADDRVEVYARDEQTLVGTAPQILKHLMEIRGIGIIDVSTLYGTGAIMPSDQISLIVHLETWTPDVQFDRLGDRGDTQTIQGVIVPKVSVPVKTGRNLAIIIESAAMNYRAETMGYDATETFDRNLNQLIKQNSERDSKNNKGSAN

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus reuteri (strain JCM 1112)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.488 kDa
Sequence
MPNNVTVQELVDKVRLKVLQGEDYLQRKITTSDISRPALEFAGYFKHYPAARIQLLGITETSFAKDLTHEQREEYMTKMCMPQTPCFVISTNLPIPKELKKAAEDAKIPILGTHLTSSQILSNMTSYLLERLAPRKSLHGVLVDISGVGVLITGDSGVGKSETALELVRRGHRLIADDRVEVYARDEQTLVGTAPQILKHLMEIRGIGIIDVSTLYGTGAIMPSDQISLIVHLETWTPDVQFDRLGDRGDTQTIQGVIVPKVSVPVKTGRNLAIIIESAAMNYRAETMGYDATETFDRNLNQLIKQNSERDSKNNKGSAN

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.857 kDa
Sequence
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANDLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQNHENRPD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Neisseria gonorrhoeae (strain NCCP11945)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.857 kDa
Sequence
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANDLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQNHENRPD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Neisseria meningitidis serogroup C (strain 053442)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.799 kDa
Sequence
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQNHENRPD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.799 kDa
Sequence
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQHNENRPD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.8 kDa
Sequence
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQHNEDRPD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Length
320 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.798 kDa
Sequence
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGNLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQNHENRPD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Treponema pallidum (strain Nichols)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
35.548 kDa
Sequence
MLKLDLKERDSLDLRCIAGHHGLANPITISDLNRPGLVLSGFFDFVAYRRIQLFGRGEHAYLLALLEQGRYGAIEKMFTFDLPCCIFSHGITPPEKFLHLAEPSSCPILVTRLTSSELSLRLMRVLSNIFAPTIALHGVLVEVYGVGILISGDSGVGKSETALELIERGHRLVADDLVEISCVNGNSLIGRGVHKSIGHHMEIRGLGIINITQLYGVGSIRERKEIQMVVQLEEWNSSKAYDRLGTQELNTTILDVSVPLIEIPVRPGRNIPIILETAAMNERLKRMGYFSAKEFNQSVLKLMEQNAAHAPYYRPDDTY

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Treponema pallidum subsp. pallidum (strain SS14)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.534 kDa
Sequence
MLKLDLKERDSLDLRCIAGHHGLANPITISDLNRPGLVLSGFFDFVAYRRIQLFGRGEHAYLLALLEQGRYGAIEKMFTFDLPCCIFSHGITPPEKFLHLAEPSSCPILVTRLTSSELSLRLMRVLSNIFAPTIALHGVLVEVYGVGILISGDSGVGKSETALELIERGHRLVADDLVEISCVNGNSLIGRGVHKSIGHHMEIRGLGIINITQLYGVGSIRERKEVQMVVQLEEWNSSKAYDRLGTQELNTTILDVSVPLIEIPVRPGRNIPIILETAAMNERLKRMGYFSAKEFNQSVLKLMEQNAAHAPYYRPDDTY

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Variovorax paradoxus (strain S110)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.484 kDa
Sequence
MKPTVISADAMFEEFRGSLRWEWLAGLGASERQFDPEVISRAQSAADLVGYLNYIHPYRVQILGAREVAYLTRGSQEDCARRIARIVTLEPPMLVLADGQAAPDELLSICERAQLPLFATRESSAFVIDLLRAYLSKHFAERTSMHGVFMDILGMGVMITGESGLGKSELGLELISRGNGLVADDAVDLFRINQNTIEGRCPDLLLNLLEVRGIGLLDIRAIFGETAVRRKMRLKLIVHLVRRDSFERDYERMPSAPLTQDVLGIPVRKVIIQVVAGRNIAVLVEAAVRNSILQLRGIDTYADFVARHHKAMESGRDGD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.194 kDa
Sequence
MNSISLAIQDLLDDTEYGLELVLLAGGAGVGHRIHSSRIQKPGLALTGYTEHLHPDRVQVLGNTEISYLQQISEQQALIHIQKLCSYPISCFIVTKGLDPPGFLKAEAERAGIPLLVTPHQSSTFISLITKFLEERLLPTTHIHGVLVDVLGVGVLILGKSGIGKSECALDLVIRGHRLVADDVVYVKKKMPAALVGQAAEAIQHHMEIRGLGVINIKNLFGVSSIREKKIIDMVIELVDWDPVQEYDRLGLDDEVYAILDVELPHIKIPVRPGRNLTSIIEVAARNHLLKGMGYHSAREFHEKLLARMEVRPLGNEVE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus casei
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of 'Ser-46' in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.348 kDa
Sequence
MADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRTEISFARNMSSEERLLILKRMATEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTRLSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVGKSETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPDKTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKNLNHLIEHNEETDQNSSGDK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus casei (strain BL23)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.348 kDa
Sequence
MADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRTEISFARNMSSEERLLILKRMATEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTRLSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVGKSETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPDKTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKNLNHLIEHNEETDQNSSGDK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.696 kDa
Sequence
MVEAVKVSELVKDVPSLKIIEGKEYLSQKLIDTSDISRPGLELTGYFDFYPKNRIQLLGRTEISYSARLDHDLRERVFNKMATPETPCFIVSRGLPIPSEMLEAAEKEKIPVFSSNMATTHLSSVITQFLDEKLAPRKSIHGVLVEIYGMGVLIIGNSGVGKSETALDLVKRGHRLIADDRVDVYQKDDKTVVGEAPKILKHLMEIRGIGIIDVMNLFGAGAVKDSTEIQLIICLQNWDPKANYDRLGFNEKTREIFEVDVPQVTVPVKVGRNLAIIIEVAAMNFRAKKMGYDASQKFEQNLTELISDNSKKDEGESKK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.717 kDa
Sequence
MVEAVKVSELVKDLPSLRVVEGKEYLDQKLINTSDISRPGLELTGYFDFYPKNRIQLLGRTEISYSARLDHDLRERVFNKMATPETPCFIVSRGLPIPSEMLEAAEKEKIPVLSSNMATTHLSSVITQFLDEKLAPRKSIHGVLVEIYGMGVLIIGNSGVGKSETALDLVKRGHRLIADDRVDVYQKDDKTVVGEAPKILKHLMEIRGIGIIDVMNLFGAGAVKDSTEIQLIICLQNWDPKANYDRLGFNEKTREIFEVDVPQVTVPVKVGRNLAIIIEVAAMNFRAKKMGYDASQKFEQNLTELISDNSKKDEGDSRK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441)
Length
319 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.348 kDa
Sequence
MADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRTEISFARNMSSEERLLILKRMATEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTRLSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVGKSETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPDKTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKNLNHLIEHNEETDQNSSGDK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.325 kDa
Sequence
MPSITVRRLYQENQQKLNLTWVAGTGGSDNVIGNDDQRPTLALVGHLNFIHPNRVQVLGLAEVDYLNKLEQSAAKTALDQLFHKSMSVVMVANGQPVPRLLRDYCHSHNVPLMCSTLESPYLMDVLRIYLARALAVSTVLHGVFLDVFEIGVLIMGDSAMGKSELALELISRGHGMVADDAVELYRIGPDTLEGRCPPLLRDFLEVRGLGILNIRTIFGETAVRPKKVLKLIIHLVKANDQAMQALDRLNIQSETQDIIGVTVRKVVLPVAAGRNLAVLVEAAVRNYILQLRGIDSTREFIERHTNFLRDQENAPDID

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Verminephrobacter eiseniae (strain EF01-2)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.561 kDa
Sequence
MKPNVVSADALFEEFRGPLKWEWVAGLGASERRFDEVVVRLASSGADLVGYLNYIHPYRVQILGEREIAYLGSASPDDCKRRIARIVTLEPPVLVLADNQTAPDALVSMCERAQIPMFSTQESAAFVIDVLRAYLSKHFADRTTMHGVFMDILGLGVMITGESGLGKSELGLELISRGNGLVADDSVDLFRINQTTIEGKCPELLQNLLEVRGIGLLDIRAIFGETAVRRKMRLKLIVHLVRKETLERDYERLPYEPLTQDVLGVPVLKVVIQVVAGRNIAVLVEAAVRNTILQLRGIDTYQEFVERHRRAMEHDNGR

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.791 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGEKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRIPEDLKNIAADFFSFHLNCIIFTHGNMPPPIFTENCERLAIPLMISDVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIRLEEWTEDKDFDRTGLENPTEELLGVQIPLIRVPVKPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSNYLQQGKVERNPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.781 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGEKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRIPEDLKNIAADFFSFHLNCIIFTHGNMPPSIFTENCERLAIPLMISDVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIRLEEWTEDKDFDRTGLENPTEELLGVQIPLIRVPVKPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSNYLQQGKVERNPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.815 kDa
Sequence
MKPTVISAEALFEAHRTALRWEWLAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLVDVPPEDQERRISRIVTLEPPVVIVADQQTPPDRLVAMCERADIPLFVTEESAGHVIDVLRAHLSQHFADRTTRHGVFMDILGLGVLLTGESGLGKSELGLELISRGHGLVADDAVDLYRVSQTALEGRCPDLLLNLLEVRGIGLLDIKAIFGETAVRRKMRLKLIVHLVRKETMERDFERLPYEPLYEDVLDVPVLKAVIAVDAGRNLAVLVEAAVRNTILKLRGIDTYQEFIARHRIAMEGDEPI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.791 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGEKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRIPEDLKNIAADFFSFHLNCIIFTHGNMPPPIFTENCERLAIPLMISDVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIRLEEWTEDKDFDRTGLENPTEELLGVQIPLIRVPVKPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSNYLQQGKVERNPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.781 kDa
Sequence
MSMPGINVSNLLNEHEELGLRLLAGEKGLTNRINMSEINRPGLSLTGFYESFAHDRIQIFGKGEWAYITSRIPEDLKNIAADFFSFHLNCIIFTHGNMPPSIFTENCERLAIPLMISDVSTHKFITLISGILDRSLAPRTMRHGVLIEVFGIGILLSGKSGVGKSETALELIERGHRLVADDMVEIRRLSESYLIGTCSDLLRHHMEIRGLGILNIKDIFGIGSVRDHKLIELIIRLEEWTEDKDFDRTGLENPTEELLGVQIPLIRVPVKPGRNIPIIVETAAMNQRLRKLGKNAAQEFNQKLSNYLQQGKVERNPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.815 kDa
Sequence
MKPTVISAEALFEAHRTALRWEWLAGHAHPERRFDEVAVRDAQSAADLVGYLNYIHPYRVQIVGRREVRYLVDVPPEDQERRISRIVTLEPPVVIVADQQTPPDRLVAMCERADIPLFVTEESAGHVIDVLRAHLSQHFADRTTRHGVFMDILGLGVLLTGESGLGKSELGLELISRGHGLVADDAVDLYRVSQTALEGRCPDLLLNLLEVRGIGLLDIKAIFGETAVRRKMRLKLIVHLVRKETMERDFERLPYEPLYEDVLDVPVLKAVIAVDAGRNLAVLVEAAVRNTILKLRGIDTYQEFIARHRIAMEGDEPI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Acidovorax citrulli (strain AAC00-1)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.689 kDa
Sequence
MKPNVVSADVLFEAFRSPLKWEWVAGLGASERRFDEVAVRSARSGADLVGYLNYIHPYRVQILGEREIAYLVNATPEDCKRRIARIVTLEPPVLVLADSQMAPDALLSMCERAQIPMFATHESSAFVIDVLRAYLSKHFADRITMHGVFMDILGLGVLITGESGLGKSELGLELISRGNGLVADDAVDFFRINQTTIEGKCPDLLQNLLEVRGIGLLDIRAIFGETAVRRKMRLRLIVHLVRKETLEREYERLPYEPLTQDVLGVPVLKVVIQVVAGRNIAVLVEAAVRNTILNLRGIDTYQEFVERHRRAMEQRDGS

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Delftia acidovorans (strain DSM 14801 / SPH-1)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.739 kDa
Sequence
MRPSAISADVLFEEFRSSLRWEWVAGLGASERRFDEMAVRSARSGADLVGYLNYIHPYRLQVLGEREIAYLSNATPQDCQRRVARIVTLEPPVLVLADGQTAPEALLSMCERAHIPMFSTREQSAFVIDVLRAYLAKHFADRTTMHGVFMDILGMGVLITGESGLGKSELGLELVTRGNGLVADDAVDLYRINQTTIEGKCPELLQNLLEVRGIGLLDIRAIFGETAVRRKMRLKLIVHLVRKETMEREYERLPAEPLTQDVLGVPVRKVVIQVVAGRNIAVLVEAAVRNAILQLRGIDTYQEFVQRHRRAMERGDTF

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Acidovorax ebreus (strain TPSY)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.504 kDa
Sequence
MKPNVVSADVLFEEFRNLLKWEWVAGLGASERRFAEVAVRAARSGADLVGYLNYIHPYRAQVLGEREIAYLTNATPEDCKRRIARIVTLEPPVLVLADGQAAPDEVVSMCERAQIPMFSTQESAAFVIDVLRAYLSKHFADRTTMHGVFMDILGLGVLITGESGLGKSELGLELITRGNGLVADDAVDLYRINQTTIEGKCPELLQNLLEVRGIGLLDIRAIFGETAVRRRMRLKLIVHLVRKETLERDYERLPYEPLTQDVLGVPVLKVVIQVVAGRNIAVLVEAAVRNTILQLRGIDTYQEFVERHRRAMERGGAS

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Acidovorax sp. (strain JS42)
Length
318 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.504 kDa
Sequence
MKPNVVSADVLFEEFRNLLKWEWVAGLGASERRFAEVAVRAARSGADLVGYLNYIHPYRAQVLGEREIAYLTNATPEDCKRRIARIVTLEPPVLVLADGQAAPDEVVSMCERAQIPMFSTQESAAFVIDVLRAYLSKHFADRTTMHGVFMDILGLGVLITGESGLGKSELGLELITRGNGLVADDAVDLYRINQTTIEGKCPELLQNLLEVRGIGLLDIRAIFGETAVRRRMRLKLIVHLVRKETLERDYERLPYEPLTQDVLGVPVLKVVIQVVAGRNIAVLVEAAVRNTILQLRGIDTYQEFVERHRRAMERGGAS

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas axonopodis pv. citri (strain 306)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.17 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGPKGEHREIQANSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISSKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.113 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGPKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISSKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. campestris (strain 8004)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.154 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. campestris (strain B100)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.154 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.154 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.055 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLGAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.055 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLGAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.055 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLGAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain M23)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain 9a5c)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain M12)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.113 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGPKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISSKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. campestris (strain 8004)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.154 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. campestris (strain B100)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.154 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.154 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.055 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLGAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.055 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLGAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.055 kDa
Sequence
MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLGAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain M23)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain 9a5c)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain M12)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.394 kDa
Sequence
MNTSITARELFDLQRDRLSLRWIAGQQGEHRQIDSGDTRARRPSLAGYLNTIYPNKVQILGTEELTWLDSLEPNKRKETIEKIIQFQPLTLVISKNQSCPEDMRTAADNSQIPLWVSPKRGHELLNHLSYHLARILAPRATLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPEILQDLLEVRGLGVLNVRHMFGDTAIKKNKYLRLIVHLTKPITEPTPSGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPATMFIARHSNLLERRPP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.012 kDa
Sequence
MTNTVKLTEFINDNSNLRVLQGQECVAGKEITVSDVYRPGLELSGYFDFYPADRVQLLGRTEISYAARLDHDLRRKVFEKICQKETPCLLVSRNLPVPVELKEAAEAAGTPILISNDATTYLMSMITQYLAVKLAERSSVHGVLVEVFGMGVLLTGESGVGKSETALALVQHGHRLIADDRVDVYQRDHETVVGEAPRILKHLMEIRGIGIIDVLKLFGIGAIKDETEISLVINLTNWDSKANYDRLGFQENTRIICGIAVTQVTIPVKVGRNMENIVEVAVMNFRAKAMGFDAAKTFDENLTSLIAENSEEEKRG

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Polaromonas naphthalenivorans (strain CJ2)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.423 kDa
Sequence
MKPTVVSADVLFEDHRATLKWEWVAGLGASERRFDEVAVSEARSGADLVGYLNYIHPYRVQILGEREVAYLSHVGPEDSARRISRIITLEPPVLVVADGQTAPDTLLSMCERAQLPMFATPESAAFVIDVLRAYLSRHFAERTSMHGVFMDILGMGVMITGESGLGKSELGLELISRGHGLVADDAIDLFRINQTAIEGRCPDLLQNLLEVRGIGLLDIKAIFGETAVRRKMRLKMIVHLVRRETLERDYERIPYEPLTQDVLGVPVRKVIIQVEAGRNIAVLVEAAVRNAILQLRGINTYQEFVERHRRAMEQDD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.504 kDa
Sequence
MKPTVVSADVLFEDHRAALKWQWVAGLGASERRFDEVAVRAARSGADLVGYLNYIHPYRVQILGEREVAYLTNESPDDCARRISRIITLEPPVLVVADDQTAPDTLLSMCERAQLPMFATPESAAFVIDVLRAYLSKHFADRTSMHGVFMDILGMGVMITGESGLGKSELGLELISRGHGLVADDAVDLYRINQTTIEGRCPELLQNLLEVRGIGLLDIKAIFGETAVRRKMRLKMIVHLVRRETLERDYERIPYEPLTQDVLGIPVRKVIIQVEAGRNIAVLVEAAVRNAILQLRGINTYQEFVERHRKAMEQDD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Stenotrophomonas maltophilia (strain R551-3)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.247 kDa
Sequence
MNTSITARELFEQQRERLGLRWAAGKSGEKRELEAGNTVSRRPSLAGYLNAIYPNKVQILGTEELSWLDALEPRQRWETIEKIMQSHPLALVLTRNQPCPEDLRAAADESGTPLWLSPKRGHELLNHLSYHLARTLAPRVILHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVREMFGDTAVKKNKYLRLIVHLTKPMTEPTPHGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Stenotrophomonas maltophilia (strain K279a)
Length
316 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
35.221 kDa
Sequence
MNTSITARELFEQQRERLGLRWAAGKSGEKRELEAGNTVSRRPSLAGYLNAIYPNKVQILGTEELSWLDALEPRQRWETIEKIMQSHPLALVLTRNQACPEDLRAAADESGTPLWLSPKRGHELLNHLSYHLARTLAPRVILHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVREMFGDTAVKKNKYLRLIVHLTKPMTEPTPHGYERLTGDSGTRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Length
315 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.872 kDa
Sequence
MAGSVTVADLVKNTRLDVYHGADLLEKKDITTSDISRPGLALTGYFNYYPRERVQLLGKTETAYSKNMSHDERLMIFRKMCQLTTPAFVISTGLPVPEELVQAGEENGVPILGTKMTSSRILSNMTNYLEGKLAERQSVHGVLVDIYGLGVLITGDSGVGKSETALELVKRGHRLIADDRVDVYQQDEQTLVGEAPAILNHLLEIRGIGIIDVMNLFGAGAVRQDTDIDLIVHLENWTPDKQFDRLGNGEQNRKFFDVEVPEISIPVKTGRNLAIIIEAAAMNFRAESMGYDATKVFDDNLNKLIKTNSVHDSHK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus xylosus
Length
314 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of 'Ser-46' in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, the HprK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.325 kDa
Sequence
MLTTKSLVERFELEMIAGEAGLNKQIKNTDISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDEERKGRMRKLCRPETPAIIVTRDLEPPEELIEAAKEHETPLITSKIATTQLMSRLTTFLEHELARTTSLHGVLVDVYGVGVLITGDSGIGKSETALELIKRGHRLVADDNVEIREISKDELIGRAPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRLRLNIHLENWHKEKLYDRVGLNEETLRILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFNDRLNAEILRNGNNGNNGEEK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Length
313 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.876 kDa
Sequence
MEKFTIKDLTDNLKFEIISGQDKLDTEIKSYGINRAGLELADYFKPFKDQSEWRATLMSTKESGYMLQFDEETKIKKYTQLMKCGIPVLIITNKFKDKTLIKVAKRLNFPLLRSDYPITIQLVQKIQDIYDIYFSPTAEEHAALMNIFGTGVLIKGKSGIGKSELCLDLIKHNHLFIGDDRIILTNKSNKIIGRVHPILKNLIEIRGIGIFDIVKSNGYQVIMNESPVELVVELVEYKEQNIDNSDRLGNDWSKFKILGVEIEHIQIPVSAGRSLVNIIESAVAQFKINKSKQFENVFDVIHKRTKEFLSSKK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma mycoides subsp. mycoides SC (strain PG1)
Length
313 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.876 kDa
Sequence
MEKFTIKDLTDNLKFEIISGQDKLDTEIKSYGINRAGLELADYFKPFKDQSEWRATLMSTKESGYMLQFDEETKIKKYTQLMKCGIPVLIITNKFKDKTLIKVAKRLNFPLLRSDYPITIQLVQKIQDIYDIYFSPTAEEHAALMNIFGTGVLIKGKSGIGKSELCLDLIKHNHLFIGDDRIILTNKSNKIIGRVHPILKNLIEIRGIGIFDIVKSNGYQVIMNESPVELVVELVEYKEQNIDNSDRLGNDWSKFKILGVEIEHIQIPVSAGRSLVNIIESAVAQFKINKSKQFENVFDVIHKRTKEFLSSKK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Length
313 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.854 kDa
Sequence
MADSVSMERLVTDLKLQVYSGEAHLKEKIVTLSDISRPGLELTGYFNYYPYERIQLFGMTEVSFTQNMTAEERLMIMRRMASENTPCFLISRSLEPPKEMLQAAEESGIPVLGSNLSTTRLSSLVTDYLDGQLAERRSMHGVLVDIYGLGVLITGDSGVGKSETALELVKRGHRLIADDRVDVYQQDERTVVGEAPMILRHLLEIRGIGIIDVMNLFGAGAVRADTSISLIVHLQNWSQDKKYDRLGSDTEEQMIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEANLGKLIESNSDDEN

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus carnosus (strain TM300)
Length
313 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.988 kDa
Sequence
MLTARALVNKFNLQLVAGEEGLDRPIHNTDISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDEERHGRLRKLCRPDTPAIIVTRDIEPPEELVVAAKELGTPLLTSKDATTSLMSRLTTYLEHELAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIREITKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKKIGLNINLENWDKNKLYDRVGLNEETLRILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFNERLNAEILRKNEHKEENES

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
313 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.197 kDa
Sequence
MLTTQSLVERFKLEVITGEAGLNKQIKNTDISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDEERKGRMRKLCRPETPAIIVTRDLEPPEELIEAAKENETPLITSTIATTQLMSRLTTFLEHELARTTSLHGVLVDVYGVGVLITGDSGIGKSETALELIKRGHRLVADDNVEIREISKDELTGRAPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRLRLNIHLENWHKEKLYDRVGLNEETLRILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFNERLNAEILRNGNHSEGNNQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Aromatoleum aromaticum (strain EbN1)
Length
313 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
34.698 kDa
Sequence
MRQTNVALLYEAQRERLALTHVSGQLDRTISVTEDRIWPADLIGHLNLIHPARLQILGAAELSWAQRQSREKIGHHLTEIINARPPAIIVADRCQPPPILCTICENADIALFTTPHPAASVIDQLRLYLSRELSEKISLHGVFMDVLGLGVFITGNSGAGKSELALELISRGHGLVADDIVEFSRIAPTVLEGRCPAMLKDFIEVRGLGILNIRTIFGETACRRKMRLRLVVHLERRLPGQTDPSRLPMHRETQEVLGVPVLRAILPVAAGRNIAVLLEAAVRSTILQLRGIDSTQEFIDRQQRMLEGEPGPD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Azoarcus sp. (strain BH72)
Length
313 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
34.335 kDa
Sequence
MRQTSVARLYEDQGPRLQLTHVSGPLDAVLSVAEERMWPADLVGHLNLIHPTRLQVLGAAELEWARRQSREKVAHHLNGILSARPPAIIVADGCETPNIVHGVCTAHNVALFSTPHPSASVIDQLRLYLSRQLAEKISLHGVFMDVLGIGVFITGNSGAGKSELALELISRGHGLVADDIVEFSRTAPTVLEGRCPELLKDFIEVRGLGILNIRTIFGETACRRKMRLRLVCHLERRQPGQDDPNRLPVQQEQQVILGVSTPRVTLPVAAGRNLAVLLEAAVRSTILQLRGVDSTQEFIDRQSRMLMGDGDGL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.87 kDa
Sequence
MMSVLVKEVIEKLRLDIVYGEPELLEKEINIADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.976 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPILTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serotype 4b (strain F2365)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.958 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPILTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDELTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
312 amino acids
Function
Is a metabolite-sensitive enzyme that catalyzes the ATP-as well as probably the pyrophosphate-dependent phosphorylation of Ser-47 in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The regulatory role of HPrK/P in the physiology of M.pneumoniae is not known yet.
Similarity
Belongs to the HPrK/P family.
Mass
35.234 kDa
Sequence
MKKLLVKELIEQFQDCVNLIDGHTNTSNVIRVPGLKRVVFEMLGLFSSQIGSVAILGKREFGFLSQKTLVEQQQILHNLLKLNPPAIILTKSFTDPTVLLQVNQTYQVPILKTDFFSTELSFTVETYINEQFATVAQIHGVLLEVFGVGVLLTGRSGIGKSECALDLINKNHLFVGDDAIEIYRLGNRLFGRAQEVAKKFMEIRGLGIINVERFYGLQITKQRTEIQLMVNLLSLEKQTTVTFERLGTELKKQRLLGVDLSFYEIPISPGRKTSEIIESAVIDFKLKHSGYNSALDFIENQKAILKRKKDES

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.976 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPILTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serotype 4b (strain F2365)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.95 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPISTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDEMTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.958 kDa
Sequence
MTKSVTVKDLKERLNLELICSETGLERPILTSDLSRPGLELTGFFSYYPEDRVQLFGMTEISFSEGMEPEERLKRYKQMCTKRTPAFVISRNLEVPKELVAAAKEADIPVLRSRLKTTRLSVYITNYLESRLAPVISMHGVLVDIYGLGVLITGSSGVGKSETALELVKRGHRLVADDNVEIRQEDELTLIGSSPAIIEHLLEIRGLGIINVMTLFGAGAVRSSKKITIVVHLENWDPDKHYDRVGLDQEKTKIFDMDIPKITVPVRPGRNLSVIIEVAAMNFRLKNMGYNAAEQFTQDLNNLIGHNSSMND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
312 amino acids
Function
Is a metabolite-sensitive enzyme that catalyzes the ATP-as well as probably the pyrophosphate-dependent phosphorylation of Ser-47 in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The regulatory role of HPrK/P in the physiology of M.pneumoniae is not known yet.
Similarity
Belongs to the HPrK/P family.
Mass
35.234 kDa
Sequence
MKKLLVKELIEQFQDCVNLIDGHTNTSNVIRVPGLKRVVFEMLGLFSSQIGSVAILGKREFGFLSQKTLVEQQQILHNLLKLNPPAIILTKSFTDPTVLLQVNQTYQVPILKTDFFSTELSFTVETYINEQFATVAQIHGVLLEVFGVGVLLTGRSGIGKSECALDLINKNHLFVGDDAIEIYRLGNRLFGRAQEVAKKFMEIRGLGIINVERFYGLQITKQRTEIQLMVNLLSLEKQTTVTFERLGTELKKQRLLGVDLSFYEIPISPGRKTSEIIESAVIDFKLKHSGYNSALDFIENQKAILKRKKDES

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.31 kDa
Sequence
MADGVSVSELVEKIRLDVFYGDELLEQKKVTVSDISRPGLELTNYFKFYPHERIQLFGETEISYAKDSMTKDERTKIYDRMADVDTPAFVVSRGLPIPEELIQAAKNNQVPILTSTLPTSRLLSNMTNFLEDRLAERDSIHGELLEIYGLGVLITGDSGIGKSETALDLIKRGHRLIADDRVDIYQQDEQTLIGEAPRILRHLLEIRGVGIIDVMNLFGASAVKNHTEISVIVHLQNWDKDAHFDRLGNGEQTRHFFELDIPKITIPVRVGRNLGDIIEAATMNFRAKNMGYDATKVFDRNLNELIKDNSQK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Length
312 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.858 kDa
Sequence
MMSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus sanguinis (strain SK36)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.169 kDa
Sequence
MSVKVKDLLKMSRLSQEYGDKVLLEKEIKTSDISRPGLEMTGYFDFYTPERIQLIGMKEWSYLMKMSSHNRHQVLLKMFQPETPVVIIARNLEIPKEMIDAADEKQVAILRSKASTSRLSGEISSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIYAKDEVTLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQIAVYLENYDTQKTFDRLGNDTEELEVAGVRIPRIRIPVKTGRNISVVIEAAAMNYRAKQMGYDATKIFEERLTDLISRNEVKHD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae (strain JJA)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.727 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae (strain P1031)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.739 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINIADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae (strain Taiwan19F-14)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.727 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.686 kDa
Sequence
MKHLTVKALVLQFNDCIQLIDGKNNIDNVITIPGLKRSVFELLGLFCKPIGSVAILGKREFIFLNQKPVEQQKKIIANLLKLKPPAVILTKSFLDCGVLLAVNQTYQVPILKTNLFSTELSFTVETYINEQFATVQKLHGVLLEIFGVGVFLEGKSGIGKSESALDLINKNHLLIGDDAIEIYRLGNRLFGRAQALAKGFMEIRGLGIINIERAYGLQITKEQTEIQLAISLLSLEEKNNASFERLGSDLKLKNLLGVKISYYQIPISSGRKTSEIIESAVIDFKLKKSGYNSANEFILKQRAMLEEQTDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.686 kDa
Sequence
MKHLTVKALVLQFNDCIQLIDGKNNIDNVITIPGLKRSVFELLGLFCKPIGSVAILGKREFIFLNQKPVEQQKKIIANLLKLKPPAVILTKSFLDCGVLLAVNQTYQVPILKTNLFSTELSFTVETYINEQFATVQKLHGVLLEIFGVGVFLEGKSGIGKSESALDLINKNHLLIGDDAIEIYRLGNRLFGRAQALAKGFMEIRGLGIINIERAYGLQITKEQTEIQLAISLLSLEEKNNASFERLGSDLKLKNLLGVKISYYQIPISSGRKTSEIIESAVIDFKLKKSGYNSANEFILKQRAMLEEQTDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.821 kDa
Sequence
MTEVVKIYQLVENLSLEVVYGDEESLNRTIKTGEISRPGLELTGYFNYYSHDRLQLFGSKEITFAERMMPEERLLVMRRLCAKDTPAFIVSRGLEIPEELITAAKENGVSVLRSPISTSRLLGELSSYLDGRLAVRTSVHGVLVDVYGLGVLIQGDSGIGKSETALELIKRGHRLIADDRVDVYQQDELTVVGEPPKILQHLIEIRGIGIIDVMNLFGASAVRGFMQVQLVVYLEAWEKDKKYDRLGSDDAMVEIANVDVPQIRIPVKTGRNVAIIIEVAAMNFRAKTMGYDATKTFEERLTRLIEENSGE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-15)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
33.932 kDa
Sequence
MQPKVRTAEIVKQFNLKIVTGEEGLHRPILTADLCRPGLVLAGYYAYYPAERLQILGKTELTFFNNLTYEEQLERANVLCTDETPGILITRGFDVPEAIVKAADETNVPLLTTKGHTTSVESQITNFLEAELAPTTAMHGVLVDIYGVGVFIKGASGVGKSETALELVKRGHRLVADDSVEIRQTGDGILVGTAPKLIQHLLEIRGIGIIDVMTLFGAGAVRSHKKISLVCNLEIWDQAKVYDRVGLDQETLQIIDTEIPFLTIPVRPGRNLAVIIEVAAMNYRLKNMGINTAEEFAGRLAQAIEDGNGGL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.299 kDa
Sequence
MQNIVRTAQVVERFKLQVIAGEEGLHRPVATPDLSRPGLVLAGYYTHYAKNRLQVLGKTELTFYASLSEEKRRERAKILCTEQTPGILITRGFDIPKEIEEEAEAANVPLMRTNAVTTSIESQITNFLEMELAPMTAMHGVLVDIYGVGVLIKGQSGVGKSETALELVKRGHRLVADDSVEIRQTGDQLLVGSAPKLIRHLLEIRGIGIIDVMTLFGAGAVRSHKKISLIVNLENWDAGKVYDRVGLDHNTMKIIDSEVPLLTIPVRPGRNLAVIIEVAAMNYRLQNMGINTAEEFAERLANAIQDTEGDL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Geobacillus kaustophilus (strain HTA426)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.632 kDa
Sequence
MPKVRTKDIIEQFQLELVSGAEGIYRPITTSDLSRPGIEMAGYFAYYPAERLQLLGRTELSFYETLTPEEKKSRMERLCTDITPGIIVSRGLEVPPELIEASERQSVPVMRSTMKTTRLSSRLTNYLESKLAPTTAVHGVLVDVYGVGVLITGKSGVGKSETALELVKRGHRLVADDCVEIRQEDEDTLVGSAPELIEHLLEIRGLGIINMMTLFGAGAVRTHKRISLVVDLELWDPEKQYDRLGLEEEKVKILDTELPKLTIPVRPGRNLAVIVEVAAMNFRLKRLGVNAAEEFSARLSDAIEDGAHDYD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Geobacillus sp. (strain WCH70)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.715 kDa
Sequence
MPKVRTKDIIEKFQLELVSGAEGIHRPITTSDLSRPGIEMAGYFTYYPAERIQLLGKTELSFYETLSLEEKKMRMERLCTDITPGIIISRGLEVPPELIEASERQSVPVMRSTMKTTRLSSRLTNYLESKLAPTTAVHGVLVDVYGVGVLITGKSGVGKSETALELVKRGHRLVADDCVEIRQEDEGVLVGSAPELIEHLLEIRGLGIINMMTLFGAGAVRTHKRISLVIDLELWDPNKQYDRLGLEEEKVKILDTELTKLTIPVRPGRNLAVIVEVAAMNFRLKRMGVNAAEEFSARLTDAIEDGEHDYE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.376 kDa
Sequence
MTESVTVAELVKANRLDVYTGKDNLDRKITTSDISRPGLELTGYFNYYPAKRVQLLGITETSFAKGMSHKELLNVMRKMCQPETPAFVISTQLDPPEELTQSAEEAGIPILGTKLTTSRVLSNMTNFLEGKLAERQSVHGVLVDIYGVGVMITGDSGVGKSETALELVKRGHRLIADDRVEVYQQDEQTLVGAAPAILSHLLEIRGIGIIDVMNLFGAGAVRSETDIDLIVHLELWQDDNHFDRLGNNSETQRFFDVVVPKISIPVKTGRNLAIIIEAAAMNFRARSMGYDATKVFDDNLKRLIKQNANKS

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.892 kDa
Sequence
MLTTEKLVKLLKLELFTGEKGLHKPIKNTDISRPGLEMAGYFSHYAADRIQLLGTTELSFYNLLPDEERHGRMRKLCRPETPAIIVTRGLEPPQELIDAAQEMDTPLIVSKDATTSLMSRLTTFLEHELAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIREITKDELIGTPPKLIEHLLEIRGLGIINVMTLFGAGSILTQKQIRLNINLENWDKDKLYDRVGLNEETLQILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFNQRLNEEILKKGHQSKEN

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.842 kDa
Sequence
MAVTVQMLVDRLKLNVIYGDEHLLSKRITTADISRPGLEMTGYFDYYAPERLQLVGMKEWSYLMAMTGHNRYQVLREMFQKETPAIVVARDLEIPEEMYEAAKDTGIAILQSKAPTSRLSGEVSWYLDSCLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDIMSLYGASAVKDSSQVQLAIYLENFETGKVFDRLGNGNEEIELSGVKVPRIRIPVKTGRNVSVVIEAAAMNHRAKQMGFDATQTFEDRLTHLISQNEVNDD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.641 kDa
Sequence
MRKTNVSHLVDHFNMTILSGEEGLGREITVTDLSRPGLQLAGYYSYFAEERIQLFGLTEINFFQTLTPEERLERMNFLMQSQVPCFCVTRNQMVPEEMIDVSNRLGVPVLQSPLATTTLVGKVTNFLENRLAPTTTIHGVLTDIYGVGVLIMGSSGIGKSEAALELVKRGHRLVADDAVEIKQTQGGQLSGSAPELIQHLLEIRGVGIINIMTMFGAGAVRNVKNIEMVVQLELWEPHKMYERLGLDEETLKIMDTEIPIITVPVRPGRNLAVIIEVAAMNFRLKRMGYNAAMHFTRKQSNAILEDADSDL

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus agalactiae serotype III (strain NEM316)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.842 kDa
Sequence
MAVTVQMLVDRLKLNVIYGDEHLLSKRITTADISRPGLEMTGYFDYYAPERLQLVGMKEWSYLMAMTGHNRYQVLREMFQKETPAIVVARDLEIPEEMYEAAKDTGIAILQSKAPTSRLSGEVSWYLDSCLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDIMSLYGASAVKDSSQVQLAIYLENFETGKVFDRLGNGNEEIELSGVKVPRIRIPVKTGRNVSVVIEAAAMNHRAKQMGFDATQTFEDRLTHLISQNEVNDD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.842 kDa
Sequence
MAVTVQMLVDRLKLNVIYGDEHLLSKRITTADISRPGLEMTGYFDYYAPERLQLVGMKEWSYLMAMTGHNRYQVLREMFQKETPAIVVARDLEIPEEMYEAAKDTGIAILQSKAPTSRLSGEVSWYLDSCLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDIMSLYGASAVKDSSQVQLAIYLENFETGKVFDRLGNGNEEIELSGVKVPRIRIPVKTGRNVSVVIEAAAMNHRAKQMGFDATQTFEDRLTHLISQNEVNDD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.164 kDa
Sequence
MSVKVKDLLQKVRLQLIYGSEDLLEKEITTSDISRPGLEMTGYFDYYTPERIQLIGMKEWSYLMKMTSHNRHQVLLKMFQPTTPVVIIARDLEIPDEMMQAAQEKQIVILRSHTSTSRLSGEISSYLDSRLAERTSIHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEMTLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQIAVYLENYDVNKTFDRLGNASDELEIAGVRIPRVRIPVKTGRNISVVIEAAAMNYRAKEMGFDATKIFEERLTNLISQNEVKHD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.884 kDa
Sequence
MSVTVQMLVDKVKLDVIYGTQELLQKEIATADISRPGLEMTGYFDYYAPERIQLLGMKEWSYLTQMTSHNRYSVLKEMFQTETPAIIVARDLTIPEEMLLAAKEEGIAVLQSHVPTSRLSGEMSWYLDSCLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVFAKDEETLWGEPAEILRHLLEIRGVGIINVMSLYGASAVKDSSQVQLSIFLENFEKDKMFDRLGNGNEDIELSGVKIPRIRIPVKTGRNVSVVIEAAAMNYRAKQMGYDATETFEKRLTNLIDQNEASHD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.739 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINIADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae serotype 19F (strain G54)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.726 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGKLSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae (strain 70585)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.727 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae (strain Hungary19A-6)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.739 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINIADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Length
311 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.727 kDa
Sequence
MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYFDYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAARECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGASAVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIEAAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.566 kDa
Sequence
MPVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus equi subsp. zooepidemicus (strain H70)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.505 kDa
Sequence
MTVTVKMLVTKVKLDVVYATDDLLEKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVIVSRGLAIPEEMVQAAQEEGIALFSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVFAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVSIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEERLTRLISKNEEGK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus uberis (strain ATCC BAA-854 / 0140J)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.927 kDa
Sequence
MTVTVKKLIERLKLEIIYANDQLLEKEITTSDISRPGLEMTGYFDYYSPERIQLFGMKEWSYMTKMTAHNRYSVLREMFKKDTPAVIVSRDLPIPEEMVKAAEEEGIALLRSKISTSRLSGSISYYLDALLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGHEEVEFAGVKVPRIRIPVKTGRNVSVVIEAAAMNHRAKQMGFDATKTFEERLTNLISRNEEMK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.627 kDa
Sequence
MSFTVKDIYDKFEVILVILDGEEKMDRVIEKPGLSRPTFELFGPFQSDPIKSAVVLGNREYSYLTSLSPEERKEKTKRLLELQPPVLILTKSFLDPVFLKECNKEYKVPILCTDMYSNELNISIGLYISKQLAKYTIHHGVLIEVYGEGVLIIGESGIGKSEVAMEMLRKNFLFVADDAISIARIGDRLIGRPTEINKHFIEVRGIGILNVTKMYGIEKIKSSAHISIVVELINIQNNQPYNFERTGQKTRYKVIENIKVPHYVLPISSGRRSSELIESAVIDLKLKRDWQYNSGDDFVERYYKYMTKEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.627 kDa
Sequence
MSFTVKDIYDKFEVILVILDGEEKMDRVIEKPGLSRPTFELFGPFQSDPIKSAVVLGNREYSYLTSLSPEERKEKTKRLLELQPPVLILTKSFLDPVFLKECNKEYKVPILCTDMYSNELNISIGLYISKQLAKYTIHHGVLIEVYGEGVLIIGESGIGKSEVAMEMLRKNFLFVADDAISIARIGDRLIGRPTEINKHFIEVRGIGILNVTKMYGIEKIKSSAHISIVVELINIQNNQPYNFERTGQKTRYKVIENIKVPHYVLPISSGRRSSELIESAVIDLKLKRDWQYNSGDDFVERYYKYMTKEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.654 kDa
Sequence
MAVSVQDLLDKIHFHVIYSTETALQKEITTSEIMRPGLEMAGYFDYFTPERIQLFGMKEWSYMMTVVGDNRYDLLKKVMAKETPVVIVARNLEIPSEMVAAAKKADIVLLQSREATSRLNSVLTSFLDERLAERTTVHGVLMDIFGVGVLIQGASGIGKSETGLELVKRGHRLVADDRVDVFQRDAFTLSGEPAEILRNMIEIRGVGIIDVMSLFGAGAVKDSTDIDMAIYLEYYDKEKAFDRLGNAPTIVEFSDVEVPQTRIPVKTGRNVSVIVEAAVMNFRAKQMGFDATKTFEDRLTDLISHNKESQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.682 kDa
Sequence
MAVSVQDLLDKIHFHVIYSTETALQKEITTSEIMRPGLEMAGYFDYFTPERIQLFGMKEWSYMMTVVGDNRYDLLKKVMAKETPVVIVARNLEIPSEMVAAAKKADIVLLQSREATSRLNSVLTSFLDERLAERTTVHGVLMDIFGVGVLIQGASGIGKSETGLELVKRGHRLVADDRVDVFQRDAFTLSGEPAEILRNMIEIRGVGIIDVMSLFGAGAVKDSTDIDMVIYLEYYDKEKAFDRLGNAPTIVEFSDVEVPQTRIPVKTGRNVSVIVEAAVMNFRAKQMGFDATKTFEDRLTDLISHNKESQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain JH1)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain USA300)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain JH9)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain COL)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain Newman)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain N315)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain MRSA252)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain MSSA476)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain MW2)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.696 kDa
Sequence
MLTTDRLVNTLNLELLTGEEGLDRPIKNTDISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDEEKKGRMRKLCRPETPAIIVTRGLEPPEELIQASQETHTPIIVAKDATTSLMSRLTTFLEHELAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIKEITKDELVGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKQIRLNINLENWNKNKLYDRVGLNEETLKILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAVEFNERLNEEIVRNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.696 kDa
Sequence
MLTTDRLVNTLNLELLTGEEGLDRPIKNTDISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDEEKKGRMRKLCRPETPAIIVTRGLEPPEELIQASQETHTPIIVAKDATTSLMSRLTTFLEHELAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIKEITKDELVGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKQIRLNINLENWNKNKLYDRVGLNEETLKILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAVEFNERLNEEIVRNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus pumilus (strain SAFR-032)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.824 kDa
Sequence
MPKVRTKDIMEQFHLELVSGEEGINRPITISDLSRPGIEMAGYFTYYPKERVQLLGKTELSFFEQLPERERKQRMMSLCTDITPAIILSRDREVPKELIEASNENGVPVLRSSLKTTRLSSRLTNFLESKLAPTTAIHGVLVDVYGVGVLLIGKSGVGKSETALELVKRGHRLVADDCVEIRQEDQDTLVGSAPELIEHLLEIRGLGIINVMTLFGAGAVRSYKRITIVMNLELWEQGKQYDRLGLEEEKMRIIDTDVPKLTIPVRPGRNLAVIIEVAAMNFRLKRMGHNAAEQFTSKLADVIEDNGQDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus clausii (strain KSM-K16)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.541 kDa
Sequence
MAKVTANDLLEKFQFELLAGEEGIYRPITTSDISRPGIEMAGFFTYYPARRLQLIGRTELSFLKSLSDQEKEERMTKLCTYDTPGIILSRGLEAPEQLIAAADKRGVPVLRSTLTTTQLSSRVTNFLESELAPVTAVHGVLVDIYGIGVLITGGSGVGKSETALDLVRRGHRLVADDSVEIRQQNEDTLVGYPPPLLQHLLEIRGLGIINVMTLFGAGAVRPFKRISLCMNLELWDQTKAYDRLGLEEDKMKIFDTEITKMTVPVRPGRNLAVIIEVAAMNFRLKRLGFNAAQEFSERLTQVIEHGENEF

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus subtilis (strain 168)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of 'Ser-45' in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on 'Ser-46'. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.702 kDa
Sequence
MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYFTYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDASEKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKSETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAGAVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.679 kDa
Sequence
MAKVRTKDVMEQFHLELISGEEGINRPITMSDLSRPGIEIAGYFTYYPRERVQLLGKTELSFFDQLPEEDKKQRMKSLCTDVTPAIILSRDMPIPPELVEASEQNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKSETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPDLIEHLLEIRGLGIINVMTLFGAGAVRSNKRITIVMDLELWEQGKQYDRLGLEEEKMKIIDTEITKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.482 kDa
Sequence
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.584 kDa
Sequence
MAKVTANDLLERFQLELLSGEEGIHRSITTSDISRPGIEMAGFFTYYPAKRLQLLGRTELSFYKQLSPVDKEERMSKLCTYDTPGIIISRGLEVPPELLKASEKVGVPVLRSNITTTRLSSMLTNFLESQLAPTTAVHGVLVDIYGIGVLITGSSGVGKSETALDLVRRGHRLVADDSVEIRREHEDTLVGRSPELIQHLLEIRGLGIINVMTLFGAGAVRPFKRIALCVNLELWDQKKVYDRLGLSEDYLRIMNVDIPKLTIPVRPGRNLAVIIEVAAMNFRLKRLGINAAQQFSDRLNDVIEEGEQEF

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.663 kDa
Sequence
MPKVRTKDVMDKFKLELISGEEGINRPITMSDLSRPGLEMAGYFTYYPKERVQLLGKTEITFFEKLPEEEKKQRMLSLCTEITPAIILSRDLPIPPELVEASEENGVPVLRSPLKTTRLTSRLTNFLESQLAPTTAIHGVLVDVYGVGVLIIGKSGVGKSETALELVKRGHRLVADDCVEIRQEDQDTLIGSAPELIEHLLEIRGLGIINVMTLFGAGAVRSFKRITLVMSLELWEQGKQYDRLGLEEETMKIIDTDVPKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTHKLADVIEDGELEE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus equi subsp. equi (strain 4047)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.505 kDa
Sequence
MTVTVKMLVTKVKLDVVYATDDLLEKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVIVSRGLAIPEEMVQAAQEEGIALFSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVFAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVSIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEERLTRLISKNEEGK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus equinus
Length
310 amino acids
Function
Catalyzes the ATP- as well as probably the pyrophosphate-dependent phosphorylation of 'Ser-46' in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, the HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it probably mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.686 kDa
Sequence
MSVTVKMLVDKVKLDVIYGDDDLLSKEITTSDISRPGLEMTGYFDYYSPERLQLLGMKEWSYLTKMTSHNRRHVLREMIKPETPAIIVARNLAIPEEMISAAKEKGIAILQSHVPTSRLSGEMSWYLDSCLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVFAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENYESGKVFDRLGNGNEELELSGVKIPRLRIPVQTGRNMSVVIEAAAMNYRAKQMGFDATKTFEERLTQLITKNEGNQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.505 kDa
Sequence
MTVTVKMLVTKVKLDVVYATDDLLEKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVIVSRGLAIPEEMVQAAQEEGIALFSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVFAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVSIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEERLTRLISKNEEGK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pyogenes serotype M1
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.57 kDa
Sequence
MTVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.566 kDa
Sequence
MPVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.57 kDa
Sequence
MTVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.57 kDa
Sequence
MTVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Length
310 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.57 kDa
Sequence
MTVTVKMLVQKVKLDVVYATDNLLSKEITTSDISRPGLEMTGYFDYYAPERLQLFGMKEWSYLTQMTSHNRYSVLKEMFKKDTPAVVVSRNLAIPKEMVQAAKEEGISLLSSRVSTSRLAGEMSYFLDASLAERTSVHGVLMDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILRHLLEIRGVGIIDVMSLYGASAVKDSSQVQLAIYLENFEAGKVFDRLGNGNEEITFSGVRIPRIRIPVKTGRNVSVVIEAAAMNHRAKEMGFDATKTFEDRLTQLITKNEVSQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus salivarius
Length
309 amino acids
Function
Catalyzes the ATP- as well as probably the pyrophosphate-dependent phosphorylation of 'Ser-46' in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, the bifunctional HPr kinase/phosphorylase is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it probably mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.44 kDa
Sequence
MTVTVKMLVDKLKLKVIYGNEKLLSKPITTADISRPGLEMTGYFDFYSPERIQLVGMKEWSYLKTLTDHNRYSVFSNMFKEETPAVIVARGLDIPEEMYRAAKENGVAVLQGRNGTSSLSGDMSWYLNAQLAERTSVHGVLVDIYGMGVLIQGDSGIGKSETGLELVKRGHRLVADDRVDVYAKDEETLWGEPAEILHHLLEIRGVGIIDVMSLYGASAVRNSSQVQLAIYLENFEDGKVFDRLGNGNEEIELQGVKIPRVRIPVKTGRNVSVVIEAAAMNYRAKQMGFDATKTFEERLTNLISKNGED

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus thermophilus (strain CNRZ 1066)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.33 kDa
Sequence
MTVTVKMLVDKLKLKVVYGNEELLAKAITTADISRPGLEMAGYFDYYSPERLQLVGMKEWTYLKTMTANNRYSVFANIFREETPAVIVARGLEIPEEMLQAAKENGVAVLQGRNSTSSLSGDMSWYLNSQLAERTSVHGVLVDIYGMGVLIQGDSGIGKSETALELVKRGHRLVADDRVDVYAKDEGTLWGEPAEILLHLLEIRGVGIIDVMSLYGASAVRDSSQVQLCICLEHFENDEVFDRLGNSNEEIELQGVKIPRIRIPVKTGRNVSVVIEAAAMNYRAKQMGYDATKTFKDRLTDLISKNGED

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.358 kDa
Sequence
MTVTVKMLVDKLKLKVVYGNEELLAKAITTADISRPGLEMVGYFDYYSPERLQLVGMKEWTYLKTMTANNRYSVFANIFREETPAVIVARGLEIPEEMLQAAKENGVAVLQGRNSTSSLSGDMSWYLNSQLAERTSVHGVLVDIYGMGVLIQGDSGIGKSETALELVKRGHRLVADDRVDVYAKDEGTLWGEPAEILLHLLEIRGVGIIDVMSLYGASAVRDSSQVQLCICLEHFENDEVFDRLGNSNEEIELQGVKIPRIRIPVKTGRNVSVVIEAAAMNYRAKQMGYDATKTFKDRLTDLISKNGED

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.332 kDa
Sequence
MTVTVKMLVDKLKLKVVYGNEELLAKAITTADISRPGLEMTGYFDYYSPERLQLVGMKEWSYLKTMTANNRYSVFANIFREETPAVVVARGLEIPEEMLQAAKENGVAVLQGRNSTSSLSGDMSWYLNSQLAERTSVHGVLVDIYGMGVLIQGDSGIGKSETALELVKRGHRLVADDRVDVYAKDEGTLWGEPAEILLHLLEIRGVGIIDVMSLYGASAVRDSSQVQLCICLEHFENDEVFDRLGNSNEEIELQGVKIPRIRIPVKTGRNVSVVIEAAAMNYRAKQMGYDATKTFKDRLTDLISKNGED

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Macrococcus caseolyticus (strain JCSC5402)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.492 kDa
Sequence
MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSFFETLSKEERAERMVKLCRKETPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISKITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSETALELVKRGHRLVADDNVEIKEVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYDRIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQIRRQSIKEI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Macrococcus caseolyticus (strain JCSC5402)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.492 kDa
Sequence
MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSFFETLSKEERAERMVKLCRKETPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISKITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSETALELVKRGHRLVADDNVEIKEVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYDRIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQIRRQSIKEI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Geobacillus thermodenitrificans (strain NG80-2)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.513 kDa
Sequence
MPKVRTKDIIEQFQLELVSGAEGIYRPITTSDLSRPGIEMAGYFAYYPAERLQLLGRTELSFYETLTPEEKRARMQRLCTDITPGIIVSRGLDVPPELIEASERQSVPVMRSTMKTTRLSSRLTNYLESKLAPTTAVHGVLVDVYGVGVLITGKSGVGKSETALELVKRGHRLVADDCVEIRQEDEDTLIGSAPELIEHLLEIRGLGIINMMTLFGAGAVLPHKRISLVIDLELWDPEKQYDRLGLEEEKMKILDIELPRLTIPVRPGRNLAVIVEVAAMNFRLKRMGVNAAEEFSARLSDAIEEGERD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lactococcus lactis subsp. lactis (strain IL1403)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.542 kDa
Sequence
MAVSVQDLLDKIHFHVIYSTETALQKEITTSEIMRPGLEMAGYFDYFTPERIQLFGMKEWSYMMTVVGDNRYDLLKKVMAKETPVVIVARNLEIPSEMVAAAKKSDIVLLQSREATSRLNSVLTSFLDERLAERTTVHGVLMDIFGVGVLIQGASGIGKSETGLELVKRGHRLVADDRVDVFQRDAFTLSGEPAEILRNMIEIRGVGIIDVMSLFGAGAVKDSTDIDMAIYLEYYDKEKAFDRLGNAPTIVEFSDVEVPQTRIPVKTGRNVSVIVEAAVMNFRAKQMGFDATKTFEDRLTDLISHNKES

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.099 kDa
Sequence
MYTVELGKLVEKMNLENCTPEIDISSIQITQPDVNRPALQLTGFFDYFDSDRVQIIGNVEHAYMQKMEKDHGLGIMKKLMSFKMPCIVFCRGIEVSEDFKEVAIEEGVPIFRTEKTTSSFMAEVIRWLKVELAPRISIHGVLVDVYGEGILIMGESGIGKSEAALELIKRGHRLVTDDLVEIKKVSDDTLIGTAPDITRHFIELRGIGIIDVKTLFGVESVKNTQSIDLVIKLEEWNRDKEYDRLGLEEQYIEFLGNRVVCHNIPIRPGRNLAVICESAAVNYRQKKMGYNAAQELYNRVTNNLLKKSK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus weihenstephanensis (strain KBAB4)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.523 kDa
Sequence
MPKVRTKDLIEQFQLELVSGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTTEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGVPLLRSAQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDTLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma pulmonis (strain UAB CTIP)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
34.716 kDa
Sequence
MKKKLFVSELIKHFDLEVLNHDFPEIEDREILTPSIKRLGLELSGHFIYDAISGVIVGWGTNESKFFEKIGSEKAKSSIEEIFSRKIPMLVLSKGFDKNYYSTIIEIANKHKTPVIFYKASLSEINTILGIYLLQYFAKKVQVHGTLVSVFGMGILIVGDSGLGKSEAALELVQKGHVLISDDAVLVSHYGNKYFGKAPYITKNLIEVRGLGLIDILSVHGLKSVLPECEINFVVELKDYEQNKSNFDRLGNKVLKYQIGEWKIPKIEIPIRQGRSVASLIEASANMFLSKLNGHDVLAMIQERSLNDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Alkaliphilus metalliredigens (strain QYMF)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
35.081 kDa
Sequence
MKSITVEKLMKDLNMEELNSIEATALLISTTDLNRPGMQLAGFFDYFAYERIQIIGKVEHRYLETLDTKTRKERLDRMMSYDIPCLIISRGLEVPEELLCTANKYQRKILRSHKNTTKLISKVINYLEDTLAPTITLHGVLMDIYGVGVLITGKSGIGKSETAVELIKRGHLLVADDAVEIKRIGHEVLQGCAPEIIRHMIEVRGIGILDVKSLFGVGAIKIKTDIDLIIDLEEWDSTKSYDRLGLDDNHREILGMKIDEVTIPIKPARNIALIIEVAARNHRQKKMGYHAAQEFNDRLMKSLEEKSQQ

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus anthracis (strain A0248)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.587 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.587 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus anthracis
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.587 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain AH820)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.596 kDa
Sequence
MPKVRTKDLIEQFHLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain G9842)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.599 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTTEQKQERMKALCTEETPCIIITRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDTLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain 03BB102)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.587 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain B4264)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.601 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain AH187)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.601 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.535 kDa
Sequence
MPKVRTKDLIEQFQLELVSGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTNDQKQERMKALCTEETPCIIVTRNQDVPKELLQASRESGVPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDVYGVGVLIIGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDTLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQNKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain Q1)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.601 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.601 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus cereus (strain ZK / E33L)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.587 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Length
309 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.587 kDa
Sequence
MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity).
Similarity
Belongs to the HPrK/P family.
Mass
35.014 kDa
Sequence
MEIRGKLFVSQVVRKFNLNVVANSDYIDREISTTGITRVGFELAGEILFKEIWNIVYFGSKESNYFNKFSETIISKKLGKILDLNPPLIIFGKNFKHAGILLKLAERYKIPIVEVKYSFYELNFTINSYISQKLSHQSLVHGTLLSVFGIGVILMGESGVGKSELAIELVKKGHIFVGDDAILVNRIGGNLYGRAEDSTKDFIEIRGLGIMNFSRSFGIERMIESTKIEIVIELIKPAKHEKIKFERFGREIQHKEFLETKIAHYYIPVIEGRSISDIIETAITDYKLKTSGYNSAEEFILQINKKGI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium kluyveri (strain NBRC 12016)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.828 kDa
Sequence
MSVTIEDIIKDLELEVINKGKNVNEINVSDINRPGLQFSGFYNYYANERVQIVGKAEWSFLDAMQPDLRKKRLEKYFEFDNPGTIVTRGLIPHKEFLESAIKNKRWILRTNNISTRFINRLMNYLDVKLAPETRLHGVLMDVYGIGILITGESGIGKSETALELIKRGHRLVADDAVDVKQIDGVLNGTSPYITSGMIEVRGMGIIDISALYGLSSVLKTKNIGLVICLEQWKKDENYDRLGIDKEYMDILNVPVRKLKIPIRPGRNLAVIIEAAAANYRYSLVSDVTPVDVISERIQELRKEDGGDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.828 kDa
Sequence
MSVTIEDIIKDLELEVINKGKNVNEINVSDINRPGLQFSGFYNYYANERVQIVGKAEWSFLDAMQPDLRKKRLEKYFEFDNPGTIVTRGLIPHKEFLESAIKNKRWILRTNNISTRFINRLMNYLDVKLAPETRLHGVLMDVYGIGILITGESGIGKSETALELIKRGHRLVADDAVDVKQIDGVLNGTSPYITSGMIEVRGMGIIDISALYGLSSVLKTKNIGLVICLEQWKKDENYDRLGIDKEYMDILNVPVRKLKIPIRPGRNLAVIIEAAAANYRYSLVSDVTPVDVISERIQELRKEDGGDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bordetella avium (strain 197N)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
33.752 kDa
Sequence
MLTVQELVDDNADNIPFNWIAGHGAADRAIPDDGMAAADLVGHLNLIHPSRVQVFGQEELAYYTRFDLRRRMHHMDELLIGGVPAILLADGLSAPQDLIDQCDQHQVPLLSTPVAAAQLIDLLRIYLGKKLAPTTTVHGVFLDVLGLGVLITGESGLGKSELALELISRGHGLVADDAVEFSRTAPNMIEGHCPQLLQNLLEVRGLGLLDIRTIFGETSVRRKMRLKLIVHLVRATAQDKFERLPLQDITQDMLGLPVRKVMLQVAAGRNLAVLVEAAVRNTILKLRGIDTLGEFMERQAMAILQSSK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
33.698 kDa
Sequence
MLTVQELVDDNADKIPFSWIAGHDAADRAIPDDGMAAADLVGHLNLIHPSRIQVFGQEELAYYTRFDLRRRMHHMDELLIGGVPAILLADGLTPPQDLIDQCAQHQVPLLSTPVAAAQLIDLLRIYLGKKLAPTTTVHGVFLDVLGLGVLITGESGLGKSELALELISRGHGLVADDAVELSRTAPGVIEGHCPQLLQNLLEVRGLGLLDIRTIFGETSVRRKMRLKLIVHLVRATAQDKFERLPLQDITQDMLGLPIRKVMLQVAAGRNLAVLVEAAVRNTILKLRGIDTLGEFMERQAMAILQSSK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
33.698 kDa
Sequence
MLTVQELVDDNADKIPFSWIAGHDAADRAIPDDGMAAADLVGHLNLIHPSRIQVFGQEELAYYTRFDLRRRMHHMDELLIGGVPAILLADGLTPPQDLIDQCAQHQVPLLSTPVAAAQLIDLLRIYLGKKLAPTTTVHGVFLDVLGLGVLITGESGLGKSELALELISRGHGLVADDAVELSRTAPGVIEGHCPQLLQNLLEVRGLGLLDIRTIFGETSVRRKMRLKLIVHLVRATAQDKFERLPLQDITQDMLGLPIRKVMLQVAAGRNLAVLVEAAVRNTILKLRGIDTLGEFMERQAMAILQSSK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
33.842 kDa
Sequence
MLTVQELVDDNADNIPFNWIAGHGAAERNIRDDGMAAADLVGHLNLIHPSRIQVFGQEELAYYSRFDLRRRTHHMDELLIGGVPAILLADGLSPPQDLIDQCDQHQVPLLSTPVAAAQLIDLLRIYLGKKLAPTTTVHGVFMDVLGLGVLITGESGLGKSELALELISRGHGLVADDAVEFSRIAPGMIEGHCPPLLQNMLEVRGLGLLDIRTIFGETSVRRKMRLKLIVHLVRATAQDKFERLPLQDITQDMLGMPVRKVMLQVAAGRNLAVLVEAAVRNTILKLRGIDTLGEFMERQAMAILQSSK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Similarity
Belongs to the HPrK/P family.
Mass
33.688 kDa
Sequence
MLTVQELVDDNADKIPFSWIAGHDAADRAISDDGMAAADLVGHLNLIHPSRIQVFGQEELAYYTRFDLRRRMHHMDELLIGGVPAILLADGLTPPQDLIDQCAQHQVPLLSTPVAAAQLIDLLRIYLGKKLAPTTTVHGVFLDVLGLGVLITGESGLGKSELALELISRGHGLVADDAVELSRTAPGVIEGHCPQLLQNLLEVRGLGLLDIRTIFGETSVRRKMRLKLIVHLVRATAQDKFERLPLQDITQDMLGLPIRKVMLQVAAGRNLAVLVEAAVRNTILKLRGIDTLGEFMERQAMAILQSSK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Peptoclostridium acidaminophilum
Length
308 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.967 kDa
Sequence
MTEDKKVSVSMFIKELELEVVHKGENTDYEIISSDINRPALQFAGFFEHFAYDRVQVIGKGEHDYFGTLDRATRLRRLEKLFSYEIPVLVLARGLDFSSDTINMAKKYNRIIIRSQMSTTKFINKASGYLSEKLAPSKTVHGVLVDIYGIGVLLMGKSGVGKSETALELVKRGHRLVADDAVEIRRIEDDMLVGEAPDILKYLMEIRGVGILDIKNLYGVGAIRTNKVVEMVAELEYWEEGKYYDRLGIDEEYMTLLDVPVEKIVIPVKPGRNLAMIIEVAAKNYRQKNMGYNAAKIFNEKLLKKLSD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium novyi (strain NT)
Length
307 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.882 kDa
Sequence
MKITVEDIIKDLELEVLVQGEKDKEIKTSDINRPGLQFAGFYSYFANSRVQVIGNAEWSFLKNMPVELIRKRMKKFFEFDTPCIIIARDLEPHPQLIKNAKLHKRWVLRSKLLTTKVVTKLMNYLDAKLAPETRMHGVLVDVYGIGMLITGESGIGKSETALELIKRGHRLVADDAVDIKEIDGVLRGTSPYITSGMLEVRGMGIIDIPALYGLSSVLQKKTIHLVIYLEQWKPDRNYDRLGIDDDFLEILNVPVKKLTVPIRPGRNLAVIIEAAAANYRYGLMCKVSPVETINNRMESMVRNESKR

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)
Length
307 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.848 kDa
Sequence
MGVTIEKLIKDFSLEVIQTGEENVPINVSDVNRPGLQLAGFYNYFAPERIQVIGKAEWSFLEDMSPDLRKKRLNKFFSFDISCLIITRGLEIHEELLKAARKRNLWILRSDMVTTKFISKITMYLSDKMAPETRLHGVLVDVYGIGMLITGESGIGKSETALELIKRGHRLVTDDAVDIKEIDGDLIGRSPEITFGMLEVRGMGIIDVSALYGLSSILNSKQIKIIIHFEHWKDDGDYDRLGVNDEYQDILGVKVKKLRVPIRPGRNIAVIIEAAAANYRYQRMSDISPVDIIEKRMLESMEKESKI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium perfringens (strain 13 / Type A)
Length
307 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.86 kDa
Sequence
MGVTIEKLIKDFSLEVIQIGEENVPINVSDVNRPGLQLAGFYNYFAPERIQVIGKAEWSFLEDMSPDLRKKRLNKFFSFDISCLIITRGLEIHEELLKAARKRNLWILRSDMVTTKFISKITMYLSDKMAPETRLHGVLVDVYGIGMLITGESGIGKSETALELIKRGHRLVTDDAVDIKEIDGDLIGRSPEITFGMLEVRGMGIIDVSALYGLSSILNSKQIKIIIHFEHWKDDGDYDRLGVNDEYQDILGVKVKKLRVPIRPGRNIAVIIEAAAANYRYQRMSDISPVDIIEKRMLESMEKESKI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium perfringens (strain SM101 / Type A)
Length
307 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.848 kDa
Sequence
MGVTIEKLIKDFSLEVIQTGEENVPINVSDVNRPGLQLAGFYNYFAPERIQVIGKAEWSFLEDMSPDLRKKRLNKFFSFDISCLIITRGLEIHEELLKAARKRNLWILRSDMVTTKFISKITMYLSDKMAPETRLHGVLVDVYGIGMLITGESGIGKSETALELIKRGHRLVTDDAVDIKEIDGDLIGRSPEITFGMLEVRGMGIIDVSALYGLSSILNSKQIKIIIHFEHWKDDGDYDRLGVNDEYQDILGVKVKKLRVPIRPGRNIAVIIEAAAANYRYQRMSDISPVDIIEKRMLESMEKESKI

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E)
Length
305 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.778 kDa
Sequence
MDKIPVETLIKDLNLEVIVEAKNNKIDITTSDVNRPGLQFSGFYEHFAYERVQIIGKVETTFIEQLPDDVLAERADRFFNYPIPCLIVTRDLNIRQEIIDAAQKHDRYLLRTKEASTKFINRLINYLDEKLAPQITIHGDLVDVYGIGVLLLGESGIGKSETALELIKRGHRLVADDAVEISKISEDKLQGSSPEIIRHFIEIRGIGILDIKTLYGVGSVRNSMNIDLVIQLEEWDEDKYYDRLGLEDDYIKFLDVKVPKLTIPVRPGRNLAIIVEVAAMNHRQKQMGYNAAHELNKKLLKQIGN

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Thermoanaerobacter sp. (strain X514)
Length
305 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.778 kDa
Sequence
MDKIPVETLIKDLNLEVIVEAKNNKIDITTSDVNRPGLQFSGFYEHFAYERVQIIGKVETTFIEQLPDDVLAERADRFFNYPIPCLIVTRDLNIRQEIIDAAQKHDRYLLRTKEASTKFINRLINYLDEKLAPQITIHGDLVDVYGIGVLLLGESGIGKSETALELIKRGHRLVADDAVEISKISEDKLQGSSPEIIRHFIEIRGIGILDIKTLYGVGSVRNSMNIDLVIQLEEWDEDKYYDRLGLEDDYIKFLDVKVPKLTIPVRPGRNLAIIVEVAAMNHRQKQMGYNAAHELNKKLLKQIGN

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium tetani (strain Massachusetts / E88)
Length
305 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.467 kDa
Sequence
MGVLVKNLVEDLKLEVLNKGKDDIELNISDINRPGLQFSGFYNYFANERVQLIGKTEWSFLDVMSPELRKKRVAKFFQFETPCVIITRNLKPHKEVLENSRKYNRWLLNTSNISTRFTSKLMNYLDEKLAPETRLHGVLVDVYGIGILITGESGIGKSETALELIKRGHRLVADDAVDIKEIEGKLIGSSPYVTSGMLEVRGLGIIDVPSLYGLSSVLDIKTIGVIIHLEQWKKDQDYDRLGIDEINRDILNVPVRKITLPIRPGRNIAVIIEAAAANYRYNLNSNSSPVDTIGARMKEENLKNK

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
304 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.445 kDa
Sequence
MQVSIEDIIENLDLEVLVKGKDGIKLGLSDINRPGLQFAGFYDYFGNERVQVIGKAEWSFLNAMPPEIREKRIRKYFQFETPCIVLARGLKPQKELLDCSKEYNRWLLRSKAQTTRFINKIMNYLDDKLAPETRIHGVLVDIYGLGILITGESGIGKSETALELIKRGHRLVADDAVDIKEIESVLVGKSPYITSGMLEVRGMGIIDVPALYGLSSVLSEKNINLVIYLEQWKEGRDYDRLGTDDEHIKILNIPVRKMTLPIRPGRNVAVIIEAAAANYRYNLSSKISPVDTINKRIEESTNYD

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium botulinum (strain Alaska E43 / Type E3)
Length
304 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.206 kDa
Sequence
MAVSVKRLINDFDLEVLVEGNEDVKIEVNDVNRPGLQLAGFYNYFAPERIQIIGKAEWSFLQDMQIEVRKKRVKKYLSFNITCLIISRGLDPHEEFIKEARKNNIWVLRSKSVTTKLISKITLYLADKLAPETRLHGVLVDVSGIGILITGESGIGKSETALELIKRGHRLITDDAVDIRESDGTLIGSSPKITIGMLEVRGIGIIDVTQLYGLSSVLEEKEIKLIMHFEHWKDDNDYDRLGIDNQYMDILGIPVKKLTVPVRPGRNIAVIIEAAAVNYRYSLMSKISPVDIIENRMSAVSDEA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium botulinum (strain Eklund 17B / Type B)
Length
304 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.292 kDa
Sequence
MAVSVKRLINDFDLEVLVEGNEDIKIEVNDVNRPGLQLAGFYNYFAPERIQIIGKAEWSFLQDMQIEVRKKRVKKYLSFNITCLIISRDLEPHEEFIKEARKNNIWVLRSKSVTTKLISKITLYLADKLAPETRLHGVLVDVSGIGILITGESGIGKSETALELIKRGHRLITDDAVDIRESDGTLIGSSPKITIGMLEVRGIGIIDVTQLYGLSSVLEEKEIKLIMHFEHWKDDNDYDRLGIDNQYMDILGIPVKKLTVPVRPGRNIAVIIEAAAVNYRYSLMSKISPVDIIENRMSAVSDEA

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)
Length
302 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.224 kDa
Sequence
MGVLVKKLIDDLNLEVLVEGKEDVEISVNDINRPGLQLAGFYNYFAPERIQVIGKAEWSFLDYMQIELRKKRVKKYFSFDINCLIITRGLEPHPEFIKEAKKHNIWFVRSNLVTTQFISKTTIYLADKLAPETRLHGVLVDVSGIGILITGESGIGKSETALELIKRGHRLVTDDAVDIKDIDGQLIGRSPKITVGMLEVRGLGIIDVTTLYGLSSVVQEKEIRLVMHFEHWKDDNDYDRLGIDNEYMNILGINVKKLTVPIRPGRNIAVIIEAAAVNYRHALMSKITPVDVIENRMNELND

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma penetrans (strain HF-2)
Length
301 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.426 kDa
Sequence
MNWKDVHKNFSNYKLESVGREKEIISNRVTRTGLEFADFFVHKDLKAVVLWGNDEYLYLKQFDEKLVKEKIEKIFQLTPPLVVLSRSFPAKGIILELAKKYDISILSTKESSADLTNYINTFLTEKLSKKEYLHGNLIELFGLGVLLMGKSGLGKSETSIELIKHGHMFIADDAIVCSNVFNKIIGRAPKRFFGFLEVRGLGIINASRVFGIEKVKESTQINVIIELVEFDPKVHTFERLGKDLQYKEILGVKIPYYLIPITPGKKTSDMIEVIVAQLKLMLSGYNSFKEMEEKSMEDDDE

Gene
hprK
Protein
HPr kinase/phosphorylase
Organism
Mycoplasma penetrans (strain HF-2)
Length
301 amino acids
Function
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
Similarity
Belongs to the HPrK/P family.
Mass
34.426 kDa
Sequence
MNWKDVHKNFSNYKLESVGREKEIISNRVTRTGLEFADFFVHKDLKAVVLWGNDEYLYLKQFDEKLVKEKIEKIFQLTPPLVVLSRSFPAKGIILELAKKYDISILSTKESSADLTNYINTFLTEKLSKKEYLHGNLIELFGLGVLLMGKSGLGKSETSIELIKHGHMFIADDAIVCSNVFNKIIGRAPKRFFGFLEVRGLGIINASRVFGIEKVKESTQINVIIELVEFDPKVHTFERLGKDLQYKEILGVKIPYYLIPITPGKKTSDMIEVIVAQLKLMLSGYNSFKEMEEKSMEDDDE