Protein
Homeodomain-interacting protein kinase 1
Organism
Caenorhabditis elegans
Function
Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood (PubMed:23904186). Plays a role in the development/differentiation of gonadal distal tip cells (PubMed:23904186). Required for normal lifespan in a pha-4 and mxl-2-dependent manner (PubMed:26791749, PubMed:29036198). Also contributes to survival following heat or oxidative stress (PubMed:26791749). Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock (PubMed:29036198). Also required for hormetic extension of longevity in response to heat stress (PubMed:29036198). Provides protection against polyglutamine aggregate formation and associated locomotory toxicity (PubMed:29036198). Also contributes to longevity by promoting autophagy under nutrient stress conditions through induction of autophagosome formation and autophagy gene expression (PubMed:29036198).
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
Sequence
MPKRKNSGQSTDLNSRSPKTIDEALRILAPPQALLVQSQLNLTAPANPFSIQKAPGTSSDNEQRAPKRRADEEAVNAVPKNLLTTSSTFARAVIPAAPAISSANNKMAPQSVTATAKTTTNRGKVSGEGEYQLIKNEVLCSPYGNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFVTMTHINGYNFANYVHEAHKRMEICRKPGPAMATPYRAANVATPITPVEKPPAPKLQQPMIAVLPQLNQIAATNIPPVPTQPDLTNLMHHYSQMAAATGSAATAAQFFYQPLPPAPLFQYAQLHHPFAARPPHFLSLATPSHMVPQFVPVPIMDPSMLQGQWPPGAAQQFAVLANDIMRVPAPQGINQMFASTPQTFSLPQFLSSSIPSATTAFNGNAPNIPFPEENSSWALGTAAQQQQQQAQRAQSMINGNVKVKPLAAQPKKNSPAPSVITLSSDEDSNGAGSSNSGSTTRTGAVNPVRNDTLPMGNTIKTEDILVPPTTFDGQLPNLQYFPGSHLFDPKTVAGLLPNPFLDTSHIPRAFN