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hpf

Gene
hpf
Protein
Putative metal ABC transporter substrate-binding protein Hpf
Organism
Haemophilus influenzae (strain NTHi 3655)
Length
293 amino acids
Function
Part of an ATP-driven transport system for iron. Metal-binding component (Potential). Acts as an adhesin that promotes binding of H.influenzae to host laminin and vitronectin. In addition, interaction with serum vitronectin plays an important role in bacterial serum resistance.
Similarity
Belongs to the bacterial solute-binding protein 9 family.
Mass
32.463 kDa
Sequence
MRNSFKIMTALALGLFAMQANAKFKVVTTFTVIQDIAQNVAGNAATVESITKPGAEIHEYEPTPKDIVKAQSADLILWNGLNLERWFERFFQNVKDKPAVVVTEGIQPLSIYEGPYKDAPNPHAWMSPSNALIYIENIKNALVKYDPQNAAVYEKNAADYAQKIKQLDEPLRAKLAQIPEAQRWLVTSEGAFSYLAKDYNLKEGYLWPINAEQQGTPQQVRKVIDLVRKNNIPVVFSESTISAKPAQQVAKESGAKYGGVLYVDSLSAKNGPVPTYIDLLNVTVSTIVKGFGK

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
219 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
25.093 kDa
Sequence
MSRLAVDSGQVLAEPKSNAEIVFKGRNVEIPDHFRIYVSQKLARLERFDRTIYLFDVELDHERNRRQRKSCQRVEITARGRGPVVRGEACADSFYAALESAVVKLESRLRRGKDRRKVHYGDKTPVSLAEATAVVPAPENGFNTRPAEAHDHDGAVVEREPGRIVRTKEHPAKPMSVDDALYQMELVGHDFFLFYDKDTERPSVVYRRHAYDYGLIRLA

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Length
203 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.626 kDa
Sequence
MTLRISGKSVSVGEALRGRVSDRTEEVLRKYFDGNYSGHITLSKDGFGFRTDCALHLDSGITLEADSNAPDAYASADQALVMIEKRLKRYKSRLKDRSARKAHVASAALAAMDATSYVLEAPGEGEDEDEVTGYSPVIIAEATTSLKQLSVSEAVMELDLSGAPCLVFQHGSSGRVNIIYRRADGNVGWVDPPGGKADGKAGG

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6)
Length
193 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.911 kDa
Sequence
MKLLIQGNNIAVTESIHDYVESKLEKATKHFQTFATKVDVHLSVANNARITDKHKAEVTVYANGTVIRAQEGSENLYASIDLVSDKIARQLRKYKEKNFGKKTHVQEKTSEVLPEDPVPDNLIGDRAPELPSEVVRMKYFAMPPMTIDEALEQLQLVDHDFYMFLNKDTNAINVIYIRNHGGYGVIQPRLGKE

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Length
192 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.184 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEDKIGKLERYFNDVPNAVAHVKVKTYQNSTTKIEVTIPLKNVTLRAEERHDDLYAGIDLVTSKLERQVRKYKTRVNRKHKTHGEPEAFVAEVQEAPPENVDDVNAEPTNDSEIEIIRSKQFSLKPMDSEEAVLQMELLGHDFYIFTDRETDGTSIVYKRKDGKYGLIETTE

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Length
191 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.021 kDa
Sequence
MQIYQLSGRNVEVTEPMREYVEEKLSRLDRYTDQITDARVTLTVRDVRNNERRNRVEVQLNVPGGIIRAEEHHADMYAAIDKASDVLERQLRKFKTRYMKQRQEGRPEPLPGPAEAEVNAQGSGAAMDDVSEFHPEIVRQKRFELRPMSAEDAVVQMEALGHDFYVFQDLQGQTGVVYRRRDGHYGLIGSS

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
191 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.895 kDa
Sequence
MKLLIQGNNITVTEAIHDYVEEKVERAVKHFQNLTTKVDVHLSVARNARITNKHKAEVTVYANGTVIRAQEGSENLYASIDLVADKIARQLRKYKERIQDKQHGNVKTSEIVEDKPVEENLIGDRAPELPSEVLRMKYFAMPPMAIEDALEQLQLVDHDFYMFRNKDTDEINVIYIRNHGGYGVIQPHQAS

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Rhizobium meliloti (strain 1021)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.232 kDa
Sequence
MSVRVSGKHMEIGDSFRVRIGEQIEQAVTKYFDGGYSSQVTVEKSGSRFSADCKLHLDTGVVLQANGQANEPQSAFDAASERIEKRLRRYKRKLKDHHNGNGQNSTEVAYRVMDSVPFEDEEVPDDYAPTIVAETTKQLRTMSVANAVMALDMTDEPVLMFRSPGKDDLNIVYRRNDGNIGWIDAANIKA

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain USA300)
Length
190 amino acids
Function
Required and sufficient for dimerization of active 70S ribosomes into 100S ribosomes. 110S ribosomes are probably translationally inactive and may serve as a reservoir of easily reactivated ribosomes when necessary in the cell. Also reduces the translation efficiency of a small number of genes. Unlike E.coli, 100S ribosomes are present during exponential growth and decrease during stationary phase. This strain produces 30% fewer 100S ribosomes than strain N315 and RN4200 under the same growth conditions (PubMed:27001516).
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes; when added to monomeric 70S ribosomes stimulates formation of 100S dimeric ribosomes. Unlike E.coli, 100S ribosomes are present during exponential growth, peak during early stationary phase and then decrease (shown for strain NBRC 3060).
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain COL)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.225 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFIDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain N315)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain MRSA252)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain MSSA476)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus aureus (strain MW2)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.213 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
190 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.17 kDa
Sequence
MIRFEIHGENLTITDAIRNYIEEKIGKLERYFNDVPNATAHVKVKTYQNSATKIEVTIPLKKVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRVNRRNRNRGEQEAFASLPEEKEAVEIQNDENEADNEIEIIRAKNFSLKPMDSEEAVLQMDLLGHDFFIFTDRETDGTSIVYKRKDGKYGLIETTE

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
189 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.064 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKVGKLERYFNNVPNAVAHVRVKTYSNSTTKIEVTIPLKDVTLRAEERHDDLYAGIDLITNKLERQVRKYKTRVNRKHRDRGDQDIFVAEVQESTTNNHADDIESENDIEIIRSKQFSLKPMDSEEAVLQMNLLGHDFFIFTDRETDGTSIVYRRKDGKYGLIETTE

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
189 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
22.064 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEEKVGKLERYFNNVPNAVAHVRVKTYSNSTTKIEVTIPLKDVTLRAEERHDDLYAGIDLITNKLERQVRKYKTRVNRKHRDRGDQDIFVAEVQESTTNNHADDIESENDIEIIRSKQFSLKPMDSEEAVLQMNLLGHDFFIFTDRETDGTSIVYRRKDGKYGLIETTE

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Staphylococcus carnosus (strain TM300)
Length
188 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.886 kDa
Sequence
MIRFEIHGDNLTITDAIRNYIEDKVGKLERYFTNVPNVNAHVKVKTYANSSTKIEVTIPLNDVTLRAEERNDDLYAGIDLITNKLERQVRKYKTRVNRKKRKESEHEPFPATPETPPETAVDHDKDDEIEIIRSKQFSLKPMDSEEAVLQMDLLGHDFFIFNDRETDGTSIVYRRKDGKYGLIETVEN

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Listeria monocytogenes serotype 1/2a (strain 10403S)
Length
187 amino acids
Function
Involved in 100S ribosome formation from 70S ribosomes; 100S ribosomes are probably translationally inactive (PubMed:25422304). Ribosome hibernation may be used by the cell to decrease overall energy consumption under nutrient-limiting conditions (PubMed:26324267). Unlike E.coli, 100S ribosomes are present from mid-exponential growth, peak during the transition from log to stationary phase and then decrease (PubMed:25422304).
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.633 kDa
Sequence
MLKYNIRGENIEVTEPIRDYVEKKIDKLERYFTETPDANVHVNLKVYSDKNAKVEVTIPLPNLVLRAEETSGDLYASIDLIVDKLERQIRKHKTKVNRKFRDKGAERDYFAYSDVNGSTPPEENEGDFDLEIVRTKQFSLKPMDSEEAVLQMNLLGHSFYVYTDAETNGTNIVYSRKDGKYGLIETN

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Length
185 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. Able to dimerize E.coli 70S ribosomes in vitro (PubMed:24279750).
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.314 kDa
Sequence
MIKFNIRGENVEVTDAIRAYVEDKIGKLDKYFNDGHEVTAYVNLKVYTEKRAKVEVTLPAKNVTLRAEDTSQDMYSSIDFVEEKLERQIRKYKTRMNRKPRNAVPTGQVFGDEFAPLDTTDEVAEDHVDIVRTKHVALKPMDAEEAVLQMDMLGHDFYVFTDADSNGTHVVYRRTDGRYGLIETE

Gene
hpf
Protein
Ribosome hibernation promotion factor
Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Length
182 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
21.1 kDa
Sequence
MIKFSIRGENIEVTEAIRDYVESKLTKIEKYFAKDQEIDARVNLKVYRERSSKVEVTIPLDSVTLRAEDVSQDMYGSIDLVVDKIERQIRKNKTKIAKKHREKVPTGQVFTTEFEAEEVDEIPEVQVVRTKNVTLKPMDVEEARLQMELLGHDFFIYTDSEDGATNILYRREDGNLGLIEAK

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
Length
116 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
13.645 kDa
Sequence
MNFKISGHHLDITPPLREYVETKLERIVRHFDQVIGVSVLLSVDNHKEKDRRQYAEINLHLKGKDIFVEAHHEDLYAAIDALVDKLDRQVIRYKDRVQGHDREAVKYQMAAAQMQQ

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Acinetobacter guillouiae
Length
113 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
13.049 kDa
Sequence
MQITIRGHHLSITPAIEENIRDRFTQMTKHIDQVNSMQVKLSKDHQLDKRSKKGSANHIAEAIVRLPGIELFAQASADDMYNAITKLTDKLKRQLDKHRKMQLDYQPMEILAT

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Azotobacter vinelandii
Length
107 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
12.255 kDa
Sequence
MQVNISGHQLDVTDALRDYVEEKISRLERHFDRITSVQVIMTVEKLKQKIEATLHVSGAEVVANAEHEDMYAAIDLLADKLDRQLIKHKEKQIERQQGQRPADSPVP

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Length
102 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
11.501 kDa
Sequence
MQVNISGQHVEVTQPLRDYVLEKLARVESHFDKITNVQVIMKVEKLQQKVEATLQIPGGEVVANAEHEDMYAAIDALADKLDRQLKKHKEKQQSLLQGAAAR

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Pseudomonas putida
Length
102 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
11.501 kDa
Sequence
MQVNISGQHVEVTQPLRDYVLEKLARVESHFDKITNVQVIMKVEKLQQKVEATLQIPGGEVVANAEHEDMYAAIDALADKLDRQLKKHKEKQQSLLQGAAAR

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Escherichia coli O157:H7
Length
95 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
10.75 kDa
Sequence
MQLNITGNNVEITEALREFVTAKFAKLEQYFDRINQVYVVLKVEKVTHTSDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTKHKDKLKQH

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
95 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
10.75 kDa
Sequence
MQLNITGNNVEITEALREFVTAKFAKLEQYFDRINQVYVVLKVEKVTHTSDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTKHKDKLKQH

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Escherichia coli (strain K12)
Length
95 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes (PubMed:18174192). Converts immature 90S particles formed by RMF into 100S ribosomes (PubMed:16324148). Crystallization with T.thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind; however RMF is still able to bind (PubMed:22605777). In this crystal binding of HPF induces movement of the 30S head domain away from the rest of the ribosome, presumably so they would more easily form dimers (PubMed:22605777). May also function as a potential translational inhibitor (PubMed:18174192).
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
10.75 kDa
Sequence
MQLNITGNNVEITEALREFVTAKFAKLEQYFDRINQVYVVLKVEKVTHTSDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTKHKDKLKQH

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Klebsiella oxytoca
Length
95 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
10.759 kDa
Sequence
MQLNITGHNVEITPAMRDFVTAKFSKLEQFFDRINQVYIVLKVEKVTQIADANLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTKHKDKLKQH

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
95 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
10.857 kDa
Sequence
MQLNITGHNVEITEALREFVTTKFAKLEQYFERINQVYVVLKVEKVTHISDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTRHKDKLKQH

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Shigella flexneri
Length
95 amino acids
Function
During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily.
Mass
10.75 kDa
Sequence
MQLNITGNNVEITEALREFVTAKFAKLEQYFDRINQVYVVLKVEKVTHTSDATLHVNGGEIHASAEGQDMYAAIDGLIDKLARQLTKHKDKLKQH

Gene
hpf
Protein
Ribosome hibernation promoting factor
Organism
Acidithiobacillus ferrooxidans
Length
78 amino acids
Function
Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
Similarity
Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
Mass
8.751 kDa
Fragment
single
Sequence
MQITITGQHLDLTDSIKNYADEKIGRLGRYFDHVSNAQVVLKHLPHEKLSNVVDITVNAPGHVFHAEVHDADMYTGID