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hpcH

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Shigella flexneri
Length
267 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.722 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGPGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEARKAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIREAGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGNSSSISMAKQNNNSVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Length
265 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.413 kDa
Sequence
MNNAFKDALKAGRPQIGLWLGLCSSYSAELLAGAGFDWLLIDGEHAPNNVPTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLVPMVQNAEEARLAVRATRYPPAGIRGVGSALARASRWNRVPDYIHQANDAMCVLVQIETREALKNLPQILDVDGVDGVFIGPADLSADMGHGGNPQHPEVQAAIEDAIQQIRQAGKAPGILMANEQLAKRYLELGALFVAVGVDTTLLARGAEALAARFTHNATTTTDNNKSVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella gallinarum (strain 287/91 / NCTC 13346)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.787 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella heidelberg (strain SL476)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.786 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPNYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella newport (strain SL254)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.815 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGVEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.758 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHLANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKNLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.787 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella paratyphi C (strain RKS4594)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.857 kDa
Sequence
MKNAFKDTLKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEPLAKRYLELGALFVAVGVDTTLLARGAEALAARFGVEKNLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella paratyphi A (strain AKU_12601)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.758 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHLANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKNLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella schwarzengrund (strain CVM19633)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.831 kDa
Sequence
MKNAFKDALKVGRPQIGLWLGLANSYSAELLAGSGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella typhi
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.787 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.814 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPEYLHLANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGVEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Klebsiella pneumoniae (strain 342)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.058 kDa
Sequence
MNNAFKDALKAGRPQIGLWLGLCSSYSAELLAGAGFDWLLIDGEHAPNNVPTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGVQTLLVPMVQNAEEARLAVRATRYPPAGIRGVGSALARASRWNRVPDYIHQANDAMCVLVQIETREALKNLPQILDVDGVDGVFIGPADLSADMGHGGNPQHPEVQAAIEDAIQQIRQAGKAPGILMANEQLAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKTDLGSSGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella agona (strain SL483)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.815 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEVLAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.703 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELVAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLVPMVQNADEARDAVAATRYPPAGIRGVGSALARASRWNRIPDYLHEANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPAVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella choleraesuis (strain SC-B67)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.857 kDa
Sequence
MKNAFKDTLKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEPLAKRYLELGALFVAVGVDTTLLARGAEALAARFGVEKNLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella dublin (strain CT_02021853)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.763 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIASYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKNLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella dublin
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.806 kDa
Sequence
MKNAFKNALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYFHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKNLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Salmonella enteritidis PT4 (strain P125109)
Length
263 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
27.787 kDa
Sequence
MKNAFKDALKAGRPQIGLWLGLANSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGAQTLLIPMVQNADEARNAVAATRYPPAGIRGVGSALARASRWNRIPDYLHQANDAMCVLVQIETREAMSNLASILDVDGIDGVFIGPADLSADMGFAGNPQHPEVQAAIENAIVQIRAAGKAPGILMANEALAKRYLELGALFVAVGVDTTLLARGAEALAARFGAEKKLSGASGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Length
262 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.1 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPNQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Shigella boydii serotype 4 (strain Sb227)
Length
262 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.047 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLSDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Shigella sonnei (strain Ss046)
Length
262 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.087 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHTPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIREAGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Escherichia coli O9:H4 (strain HS)
Length
262 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.057 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIREAGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Length
262 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.073 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Escherichia coli
Length
262 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinate semialdehyde. Is also able to catalyze the aldol cleavage of 4-hydroxy-2-ketopentanoate and 4-hydroxy-2-ketohexanoate. Is not stereospecific since it can cleave both substrate enantiomers. Also exhibits significant oxaloacetate decarboxylase activity in vitro. In the reverse direction, is able to condense a range of aldehyde acceptors (from two to five carbons in length) with pyruvate or 2-oxobutanoate. Unlike with BphI from Burkholderia xenovorans, the aldol addition reaction lacks stereospecificity, producing a racemic mixture.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.073 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY

Gene
hpcH
Protein
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase
Organism
Escherichia coli (strain SE11)
Length
262 amino acids
Function
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
Similarity
Belongs to the HpcH/HpaI aldolase family.
Mass
28.073 kDa
Sequence
MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHAPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY