Protein
Hepatocyte nuclear factor 4-beta
Function
Transcription factor; binds and activates the promoter for the HNF1-alpha gene. Seems to have a lower DNA binding activity than HNF4-alpha and is a weaker transactivator than the alpha isoform.
Similarity
Belongs to the nuclear hormone receptor family. NR2 subfamily.
Sequence
MDMPDYTETLDSSYTMLEFDSIRVLPSNTEIITVETASPGLLNNGINSFCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHVYACRFSRQCIVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISMRRSSYEDNGSLSINVLTQAEAMVHQYSPVSPVHSSDISMKKVASISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRSLPYKDFLLLGNDFIMPMHCPELEIARVPCRILDELVKPLREIQIDDNEYVCLKAIIFFDPDCKGLSDQTKVKNMRFQVQVNLEDYINDRQFDSRGRFSDILLLLPPLQSITWQMIEQVQFAKLFGVARIDSLLQELLLGGTTMDGGQYINSGHSSLNLDLLPGPTVHSHNLHSVIHTVSSLSPETSPPTNSTSEDYKMNTATVSSIPLMQRTVIAKKEIL