Protein
Hydroxymethylglutaryl-CoA synthase
Organism
Caenorhabditis elegans
Function
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Similarity
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Sequence
MSLGQLSYTPVTDVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVTRKLIETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFPGNSDIEGVDIKNACFGGAQALLHAIDWVTVNHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPIDRQFSACHMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTYFISKVNRHTTGIDGLNSFDGVFLHSPFTKMVQKGLAVMNYTDSQLRHKQLNGNGVDHKLDENDRAGLAKMIELSAQVWKEKTDPYLVFNRRIGNMYTPSLFAQLLAYLAADDCVTGEKSILFFAYGSGLASAIFPGRVRQTSNLDKIRQVAIRAIKRLDDRIQFTPEEFTETLQKREVFLRSKEIPKSPSETSLFPNTYFLDNMDKLYRRSYTLHEEPNGVQNGNGIHH