About Products Protein Database Contact

hmgB

Gene
hmgB
Protein
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Organism
Dictyostelium discoideum
Length
526 amino acids
Function
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis.
Similarity
Belongs to the HMG-CoA reductase family.
Mass
56.16 kDa
Sequence
MIRIGSNLIKQSIKNTNKSGISRFFTTGSNNSTNYKPESCVKEEPKGKSVNVEDLKDQEIIALVDKGEIQPHNLETRLPNNFQRAVHIRRKLLARDLQKEHQRALHAQAVVAAAEKAATSGEDPSSIQPVVPPTSNLDFEGSLTNLPVDHFDYTKVLGACCENVIGYIPIPVGVAGPILLDGKLVSIPMATTEGCLVASTHRGAKAITKSGGAKTVLLQSGMTRAPVCRLPSSIRAGELKQWIENQENFYQVASAFNSTSRFARLKSIKVVIAGRLVYLRFKSSTGDAMGMNMVSKGVEKALEVITEYFPEMEVLSLSGNVCTDKKPSSINWLEGRGKSVVAEAVISGDIVRDVLKTTVEALVSLNIDKNLIGSAMAGSIGGFNAHASNIVTALYIATGQDPAQNVESSNCITLMESINGGKDLYISVTMPSIEVGTVGGGTHLPAQSACLDLLKIRGANLERPGANSEQLARVVAAAVLSGELSLMSALAAGHLVRSHLKHNRKTEAPAPQADTISMTHNLPHSD

Gene
hmgB
Protein
Hydroxymethylglutaryl-CoA synthase
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Length
445 amino acids
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Similarity
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Mass
50.103 kDa
Sequence
MTSVGIDAMEIWTGKLVLDLPNTFAPVKGEDPEKYTKGLGLHTSSFPDVYEDIVTMGANAAKKLMDRKGLTPADIGRIDVATESAFDNSKPVSTYIAGCLEQVYDGDFRHANKGERKFACIAGTQSLDDAYNWIKAGRNRGRAALVIATDTALYERGDPGEATQGAGAVAMLIDEDPDLVELSTEQGYGSMDETDFLKPNQQFPSVDGKRSMQVYLARMREALEDYESVAGRTHPDLFEYIPFHTPFPGMVRKAALLGFRHMTRDTDIEDDLESEIGRQPREEDFETWDDYEEAIRGYMDELKTTEQYRDWYGRVIEPTLDISSRVGNWYTGSVHIARLSALKAAADEGKDMTGKQLLVGSYGSGAQAEIHAERVQETWLDEIEAVDVDDQLAARTEISFDDYELIHDVHNHEKEIEVEEFTQPEAEFVFTGWGRMNERRYEYVE