Protein
Hydroxymethylglutaryl-CoA synthase
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Similarity
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Sequence
MTSVGIDAMEIWTGKLVLDLPNTFAPVKGEDPEKYTKGLGLHTSSFPDVYEDIVTMGANAAKKLMDRKGLTPADIGRIDVATESAFDNSKPVSTYIAGCLEQVYDGDFRHANKGERKFACIAGTQSLDDAYNWIKAGRNRGRAALVIATDTALYERGDPGEATQGAGAVAMLIDEDPDLVELSTEQGYGSMDETDFLKPNQQFPSVDGKRSMQVYLARMREALEDYESVAGRTHPDLFEYIPFHTPFPGMVRKAALLGFRHMTRDTDIEDDLESEIGRQPREEDFETWDDYEEAIRGYMDELKTTEQYRDWYGRVIEPTLDISSRVGNWYTGSVHIARLSALKAAADEGKDMTGKQLLVGSYGSGAQAEIHAERVQETWLDEIEAVDVDDQLAARTEISFDDYELIHDVHNHEKEIEVEEFTQPEAEFVFTGWGRMNERRYEYVE