Protein
Putative imidazole glycerol phosphate synthase subunit hisF3
Organism
Vibrio vulnificus (strain YJ016)
Function
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
Similarity
Belongs to the HisA/HisF family.
Sequence
MRVYRMLRSRVIPVLLMREKGLVKTVKFKEGKYVGDPLNAVKIFNEQEADELTLLDIDASRLGHEPDYVLIERIASECRMPLCYGGGIKTVEQAERILKLGVEKVSLSSAVFENPKIITQLAERVGRQSIVVCLDVKKRLFGSKFDCFTINGTKKQSVDTIEFVKQIQTLGAGEIVLNFIDNDGVMKGYDLDAVSKFKALVKVPLTVVGGAGCVDDIAKLVQQEKLVGAAAGSLFVFKGKYKAVLINYPSPSEKKKALEL