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hir-1

Gene
hir-1
Protein
Protein hir-1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
1035 amino acids
Function
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
Similarity
Belongs to the WD repeat HIR1 family.
Mass
112.439 kDa
Sequence
MHLIKPSWLSHSGEQKDFEVYSCHVSPDGKRLATAGGDGHVRVWSVEAIFNSHDRNYTKPRQLCHMSHHLGTIHSVRFSPNGRYLASGADDKIICIYHLDSNPPSHTSTFGTNEPPPVENWKTYKRLVGHDNDVQDLAWSPDNSLLVSVGLDSKIVVWSGHTFEKLKTLAVHQSHVKGITFDPANKFFATASDDRTIKIFRYTAPAPNATQHDMVNNFILETSISVPFKHSPLTTYFRRCSWSPDGNHIAAANAVNGPVSSIAIIERTGWDSEINLIGHEAPTEVCMFSPRLFYTQKPDENSNANGAASPGLVTVIASAGQDKTLTIWNTNTSRPVLIVQDIASKSVSDLAWTPDGQTVFAASLDGGVIAAQFETGELGWVAKSEENDKALQKYGGSRKGMGTAEDVDGLHLENHSKEKELRGAESRMGALMGDPGPAQKETATTTNGVKPAGKAADTNGTTTPAPPEKPEEESADKTAERIAELKSRVTITKDGKKRVAPLLVSSSGTGLSSLPQAQLVGASSTKPVQNDNPQTILDLSKPYDGLPRGGIAAMLLGNKRKAVIVEDEEEEEPSAKRSATGPVPIVVNGVEGLEPAPLSAPAHGLVPTPEFLRPAVISPNIAYSQVRLAVPKIRSHILRPLERGVLQEETSLEDATKVPENIVLEAKNPAHIREPARITATKRGALLWQDFLPRAIILVAGSKHFWAAACEDGTLHTWSPAGRRLMNAIMLESQPVILEARDSWLLCVTAVGLCHVYNIKTMSSPHPPVSLAPILDVAMTSLSPHGATPAPGVTSAHLNSSGVIVVTLSNGDGFYYSTSLYAWQRLSESWWAVGSQYWNSNDSSVSALQTTAVGPVSGAKNGEGETNVSAGIIPYLERHTTTEFLLKGRAYTLQRLVKALLARDGFENFESSVSIAHLENRIAGAFALGAREEFRLYLFMYAKRIGAENQKTKVEELLNSLIGGVLRDADDGEGWFSKQDKLCGWDRKDLLQGVVLILGKFRDLHRLTVQYARILDMTLGDEEKETTDEGMEVED