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hif-1

Gene
hif-1
Protein
Hypoxia-inducible factor 1
Organism
Caenorhabditis elegans
Length
719 amino acids
Function
A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size (PubMed:11427734, PubMed:12006646, PubMed:12686697, PubMed:15781453, PubMed:18477695, PubMed:19461873, PubMed:21093262, PubMed:19889840, PubMed:20520707, PubMed:20400959). Involved in mediating susceptibility to enteropathogenic E.coli (PubMed:16091039). Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection (PubMed:20865124, PubMed:22792069). Required for aha-1 nuclear localization (PubMed:11427734). Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression (PubMed:20400959). Role in life span extension is dependent of temperature (PubMed:21241450). Not required for survival in anoxic conditions (PubMed:11427734). Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3 (PubMed:22396654, PubMed:22194696). May be involved in manganese homeostasis by repressing divalent metal transporter smf-3 (PubMed:22194696).
Mass
79.934 kDa
Sequence
MEDNRKRNMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLDNEITNEVWTEDTIAECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQSKMLHKPRGEDTDTTGINMVLRMKTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTNANASAMTKYTESPMGAFTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKSMKELFAKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSMPAGMQVDIKKEVDDTRDYIGRQPEIVECVDFTPLIEPEDPFDTVIEPVVGGEEPVKQADMGARKNSYDDVLQWLFRDQPSSPPPARYRSADRFRTTEPSNFGSALASPDFMDSSSRTSRPKTSYGRRAQSQGSRTTGSSSTSASATLPHSANYSPLAEGISQCGLNSPPSIKSGQVVYGDARSMGRSCDPSDSSRRFSALSPSDTLNVSSTRGINPVIGSNDVFSTMPFADSIAIAERIDSSPTLTSGEPILCDDLQWEEPDLSCLAPFVDTYDMMQMDEGLPPELQALYDLPDFTPAVPQAPAARPVHIDRSPPAKRMHQSGPSDLDFMYTQHYQPFQQDETYWQGQQQQNEQQPSSYSPFPMLS