Protein
Modification methylase HgiCII
Organism
Herpetosiphon aurantiacus
Function
This methylase recognizes the double-stranded sequence GGWCC, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the HgiCII endonuclease.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Sequence
MKQFRFIDLFAGIGGFRLGLEAVGGICVGSAEIDQQAIKVYRQNWPTDRSEHNLGDITTLQQLPAHDLVVGGVPCQPWSIAGKNQAFDDPRGQLWADVIRLVRINQPKAFIFENVKGLIDPRNRLCLESILDSFKAEGYNVYYKLLNSFDYGVAQNRDRVFIIGIQQKLGVPDFSFPEYSESEQRLYDILDNLQTPSIIPESLPIQRNLFGERIEVGFNKLTPRGAFNDFFILNDIRNGPTSIHSWEIYATTEREKQICTTIMRNRGNPRYGDCDGNPMSYQDIADLVVDLAESELQVLIQKRILRQYEDGKYEFFNRRLSGGIDGTYRIFLPHARFFGRLTARGMHDEIAEISVSGATAEAYKQNFIQQILIPKRHRPITVNEAARIQGFPATFKFHSNQSANFRLIGNSVAPPVIMALGKALPNDHLFEPELCEV