Protein
Transcription factor HES-1-A
Function
Transcriptional repressor of a subset of early mesodermal genes including myod1 and t/bra. Binds DNA on N-box motifs: 5'-CACNAG-3'. Acts as a negative regulator of myogenesis, mediating Notch signaling to repress expression of myod1.
Sequence
MPADVMEKNSSSPVAATPASVSNTPDKPKTASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRVQMSAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTDVRTRLLGHLANCMNQINGMNYPTQPQMPSAAAPHPAYGQPMVQLPGAAPQSSPAPIACKMGGPPVEAAKVYGGFQLVPAPDGQFAFLITNPAFPHNGSVIPVYTNSNVGTALPPSVSPSVMPSVTIDSVWRPW