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hepC

Gene
hepC
Protein
Heparin-sulfate lyase
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Length
702 amino acids
Function
Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.
Similarity
Belongs to the polysaccharide lyase 12 family.
Mass
79.423 kDa
Sequence
MKNIFFICFCALFAFSGCADDDDDLLTGGNVDIDLLPDAKPNDVVDPQVFEAINLNYPGLEKVKEFYEAGEHYYAANALLEYYRTRTNVTNPNLSLINVTISEAEQAKADYALVDYRFHVNNFYEDKETLKPYSVKQDGGINWEYSPKDASDEYQKQLHRHQWFIPQAKAYRVSGDEKYIQSWIEVYKNWIENNPKPTTGPNTTSWWQLQVSTRIGDQVQLLEYFKNSVNFTPEWLSTFLVEFAEQADFLVDYPYESGGNILISQANALATAGTLMPEFKNAEKWMNTGYQILSEEVQNQIMSDGWHKEMSLHYHIGIVADFYEAMKLAEANQLSSKLPSDFTEPLRKAAEVVMYFTYPNYFIKGSDNVVPMFNDSWSRTRNVLKNTNFKQYVEMFPDSEELKYMQTAGNGGTAQGRTPNNDMKLFDQAGYYVLRNGWTPASTVMILSNNKSNDASNSLSAYSHNQPDNGTFELYHNGRNFFPDSGVCTYYTSGGDNDLRYWFRGIDKHNTLSIGKQNIKKAAGKLLKSEEGATELVVFENQGYDNLKHRRAVFYVNKKFFVLVDEGIGNAEGTINLSFNLCEGTASEVVMDTDKNGVHTAFSNNNNIIVRTFANKAVTCSPFTGRIAYLVDGAYNTRQSYTIDMNKSADETARYITVILPVNGSTDTSSISAKFIDSGYSENSASVEVSVNGETHTLSYTL
Protein
Heparin-sulfate lyase: hepC

Gene
hepC
Protein
Heparin-sulfate lyase
Organism
Bacteroides stercoris
Length
666 amino acids
Function
Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Also able to degrade heparin and hyaluronic acid. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.
Similarity
Belongs to the polysaccharide lyase 12 family.
Mass
77.325 kDa
Sequence
MNKTFKYIVLLALACFVGKANAQELKTEVFSLLNLDYPGLEKVKALHQEGKDADAAKALLDYYRARTNVKTPDINLKKVTIGKDEQKMADEALQHTFFAHKGYQPSFNYGEDIDWRYWPVKDNELRWQLHRHKWFTPMGKAYRVSGDEKYAVEWTKQYIDWIKKNPLVKVDKKEYEMTGDNQLKGDVENARFAWRPLEVSNRLQDQTSQFQLFLPSPSFTPEFLTEFLVNYHKHAIHILGIYSAQGNHLLFEAQRMIYAGAFFPEFKEAAAWRKSGIDIMNREINVQVYNDGGQFELDPHYHLAAINIFCKALNIADLYGFRNEFPQEYLDTIEKMIVFYANVSFPDYTNPCFSDAKLTNKKEMLKNYRNWSKMFPKNQFIKYLATDGKEGALPEYLSKGFLKSGFFVFRNSWGTDATQMVVKAGPKAFWHCQPDNGTFELWFNGKNLFPDSGSYVYAGEGEVMEQRNWHRQTCVHNTVTLNNKNLDQTESVTKLWQPEGNVQILVTENPSYKNLKHRRSVFFVDNSYFVIVDEMVGSQKGSINLHYQMPKGEIANSREDMTFVTQFEEGSNMKLQCFGPEGMTMKKEPGWCSTAYRKRYKRMNVSFNVKKDSEDAVRYITVICPIKNSADAPKLSAKFKNKTFNENGLEVEVKVNGKKQSLNYKL
Protein
Heparin-sulfate lyase: hepC

Gene
hepC
Protein
Heparin-sulfate lyase
Organism
Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3)
Length
659 amino acids
Function
Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.
Similarity
Belongs to the polysaccharide lyase 12 family.
Mass
75.807 kDa
Sequence
MTTKIFKRIIVFAVIALSSGNILAQSSSITRKDFDHINLEYSGLEKVNKAVAAGNYDDAAKALLAYYREKSKAREPDFSNAEKPADIRQPIDKVTREMADKALVHQFQPHKGYGYFDYGKDINWQMWPVKDNEVRWQLHRVKWWQAMALVYHATGDEKYAREWVYQYSDWARKNPLGLSQDNDKFVWRPLEVSDRVQSLPPTFSLFVNSPAFTPAFLMEFLNSYHQQADYLSTHYAEQGNHRLFEAQRNLFAGVSFPEFKDSPRWRQTGISVLNTEIKKQVYADGMQFELSPIYHVAAIDIFLKAYGSAKRVNLEKEFPQSYVQTVENMIMALISISLPDYNTPMFGDSWITDKNFRMAQFASWARVFPANQAIKYFATDGKQGKAPNFLSKALSNAGFYTFRSGWDKNATVMVLKASPPGEFHAQPDNGTFELFIKGRNFTPDAGVFVYSGDEAIMKLRNWYRQTRIHSTLTLDNQNMVITKARQNKWETGNNLDVLTYTNPSYPNLDHQRSVLFINKKYFLVIDRAIGEATGNLGVHWQLKEDSNPVFDKTKNRVYTTYRDGNNLMIQSLNADRTSLNEEEGKVSYVYNKELKRPAFVFEKPKKNAGTQNFVSIVYPYDGQKAPEISIRENKGNDFEKGKLNLTLTINGKQQLVLVP
Protein
Heparin-sulfate lyase: hepC