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hemN

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
Length
494 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
54.499 kDa
Sequence
MIPSAITSPAPDRRALSDFRALAGRIDGNGPRYTSYPTADRFHNGPDLSLYHDALAACRADAPAPLSLYLHIPFCENICYYCGCNKIITRDHGRSARYVNYLGREMALVADRLGPRRQVLQSHWGGGTPTFLDPGEMRRVMALLHEHFELAAEGEHSIEIDPRRVDHARMALLAELGFNRVSLGVQDFDPEVQQAIHRIQPFEETRAVVDAARTLGFRSVSLDLIYGLPHQTAARFGRTIDQVLALRPDRLSVYSYAHLPHVFKPQRRIDENALPPAGEKLDILVSTIERLSAEGYVYIGMDHFALPDDDLAVAQREGRLQRNFQGYSTHAGYDQVGLGISAIGAIAGRYVQNARTLDEYYGALDHGRLPLARGVAMSADDHLRREIIGALMCNGVLDIPALEARHGIRFGTAFAPELADLAALGADGLVQCAPDRITVTPLGRLLVRRVAMVFDRYLREDAARPASTGAQAVAANDGAQPVRFVPRARYSRVV

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
466 amino acids
Function
Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
53.161 kDa
Sequence
MTTTFPTVEFSAELLNKYNQGIPRYTSYPPATELNKEFDPSDFQTAINLGNYKKTPLSLYCHIPFCAKACYFCGCNTIITQHKPAVDPYLKAVAKQIALVAPLVDQQRPVQQLHWGGGTPNYLTLEQAEFLFNTITDAFPLAENAEISIEINPCYVDKDYIFALRQLGFNRISFGIQDFNSQVQQAVNRIQPEAMLFQVMDWIRQANFDSVNVDLIYGLPHQNLATFRETLRKTAQLNPDRIAVFNFAYVPWLKPVQKKMPESALPPAEEKLKIMQATIADLTEQGYVFIGMDHFAKPDDELAIAQRRGELHRNFQGYTTQPESDLLGFGITSISMLQDVYAQNHKTLKAFYNALDREVMPIEKGFKLSQDDLIRRTVIKELMCQFKLSAQELESKYNLGFDCDFNDYFAKELSALDVLEADGLLRRLGDGLEVTPRGRILIRNIAAVFDTYLQNKSKQQMFSRAI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
466 amino acids
Function
Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
53.161 kDa
Sequence
MTTTFPTVEFSAELLNKYNQGIPRYTSYPPATELNKEFDPSDFQTAINLGNYKKTPLSLYCHIPFCAKACYFCGCNTIITQHKPAVDPYLKAVAKQIALVAPLVDQQRPVQQLHWGGGTPNYLTLEQAEFLFNTITDAFPLAENAEISIEINPCYVDKDYIFALRQLGFNRISFGIQDFNSQVQQAVNRIQPEAMLFQVMDWIRQANFDSVNVDLIYGLPHQNLATFRETLRKTAQLNPDRIAVFNFAYVPWLKPVQKKMPESALPPAEEKLKIMQATIADLTEQGYVFIGMDHFAKPDDELAIAQRRGELHRNFQGYTTQPESDLLGFGITSISMLQDVYAQNHKTLKAFYNALDREVMPIEKGFKLSQDDLIRRTVIKELMCQFKLSAQELESKYNLGFDCDFNDYFAKELSALDVLEADGLLRRLGDGLEVTPRGRILIRNIAAVFDTYLQNKSKQQMFSRAI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
460 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
52.488 kDa
Sequence
MLDTIRWDADLIRRYDLSGPRYTSYPTAVQFHEGIGPFDQLHALRDSRKAGHPLSLYVHIPFCANICYYCACNKVITKDRGRSAPYLARLVREIEIVSRHLSREQVVEQLHFGGGTPTFLSPGQLRELMSQLRTHLNLLDDDSGDYGIEIDPREADWSTMGLLRELGFNRVSLGVQDFDMEVQKAVNRMQTPEETRTIVEAARTLQYRSINLDLIYGLPKQTPDSFARTVDEVIALQPDRLSVFNYAHLPERFMPQRRINADDLPSPGQKLEMLQRTTEQLAAAGYRYIGMDHFALPDDELASAQEDGTLQRNFQGYTTHGHCDLVGLGVSAISQIGDLYSQNSSDINDYQTSLDNGQLAIRRGLHCNSDDRVRRAVIQQLICHFELAFEDIETEFGIDFRSYFAELWPDLERFAADGLIRLDAKGIDITSSGRLLVRSICMLFDRYLPSLNRQRFSRVI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
460 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
52.488 kDa
Sequence
MLDTIRWDADLIRRYDLSGPRYTSYPTAVQFHEGIGPFDQLHALRDSRKAGHPLSLYVHIPFCANICYYCACNKVITKDRGRSAPYLARLVREIEIVSRHLSREQVVEQLHFGGGTPTFLSPGQLRELMSQLRTHLNLLDDDSGDYGIEIDPREADWSTMGLLRELGFNRVSLGVQDFDMEVQKAVNRMQTPEETRTIVEAARTLQYRSINLDLIYGLPKQTPDSFARTVDEVIALQPDRLSVFNYAHLPERFMPQRRINADDLPSPGQKLEMLQRTTEQLAAAGYRYIGMDHFALPDDELASAQEDGTLQRNFQGYTTHGHCDLVGLGVSAISQIGDLYSQNSSDINDYQTSLDNGQLAIRRGLHCNSDDRVRRAVIQQLICHFELAFEDIETEFGIDFRSYFAELWPDLERFAADGLIRLDAKGIDITSSGRLLVRSICMLFDRYLPSLNRQRFSRVI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Length
457 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
53.246 kDa
Sequence
MQTIDFEKFSQYSKPGPRYTSYPTAVEFNENFNEESLKTAFFNHDNLKNPMPLSLYTHLPFCRSACYFCACSVIYTSLEEKKIRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFSPIQLDEITQSIQEVFPNFSKDIEMSCEIDPRHFTKEHMQTLFDRGFNRLSFGVQDFDFEVQKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKEGFLKTLEWVLKLDPDRLAVFNYAHVPWVKKTMRKIDETLLPSLRDKLEILESLISFLEKANYQMIGMDHFAKSDNELYLALQKAELRRNFQGYTTKKFTQTIGIGVTSIGEGGDYYTQNYKDLHHYEKALDLGHLPVERGVALSQEDVLRKEVIMQMMSNLKLDYSKIEEKFSVDFKAHFKKELEKLKPYEEAGLLSFNSKGFEMTKTGGMLVRNMAMEFDAYLRGGEKHFSKTL

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
457 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
52.828 kDa
Sequence
MSEQQIDWDLALIQKYNYSGPRYTSYPTALEFSEDFEDAAFLQAVARYPERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIRHRAPLFADRHVSQLHWGGGTPTYLNKAQISRLMTLLRENFHFNTDAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHARDIGFTSTNIDLIYGLPKQTPESFAFTLKRVTELNPDRLSVFNYAHLPTLFAAQRKIKDADLPSAQQKLDILQETIVSLTQAGYQFIGMDHFARPDDELAVAQREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDGYMQNQKELKRYYQQVDERGNALWRGITLTRDDCIRRDVIKALICNFRLDFNAVEQQWGLHFAEYFAEDLQLLSPLAKDGLVDISEKGIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Length
457 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
53.246 kDa
Sequence
MQTIDFEKFSQYSKPGPRYTSYPTAVEFNENFNEESLKTAFFNHDNLKNPMPLSLYTHLPFCRSACYFCACSVIYTSLEEKKIRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFSPIQLDEITQSIQEVFPNFSKDIEMSCEIDPRHFTKEHMQTLFDRGFNRLSFGVQDFDFEVQKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKEGFLKTLEWVLKLDPDRLAVFNYAHVPWVKKTMRKIDETLLPSLRDKLEILESLISFLEKANYQMIGMDHFAKSDNELYLALQKAELRRNFQGYTTKKFTQTIGIGVTSIGEGGDYYTQNYKDLHHYEKALDLGHLPVERGVALSQEDVLRKEVIMQMMSNLKLDYSKIEEKFSVDFKAHFKKELEKLKPYEEAGLLSFNSKGFEMTKTGGMLVRNMAMEFDAYLRGGEKHFSKTL

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
457 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
52.828 kDa
Sequence
MSEQQIDWDLALIQKYNYSGPRYTSYPTALEFSEDFEDAAFLQAVARYPERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIRHRAPLFADRHVSQLHWGGGTPTYLNKAQISRLMTLLRENFHFNTDAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHARDIGFTSTNIDLIYGLPKQTPESFAFTLKRVTELNPDRLSVFNYAHLPTLFAAQRKIKDADLPSAQQKLDILQETIVSLTQAGYQFIGMDHFARPDDELAVAQREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDGYMQNQKELKRYYQQVDERGNALWRGITLTRDDCIRRDVIKALICNFRLDFNAVEQQWGLHFAEYFAEDLQLLSPLAKDGLVDISEKGIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Escherichia coli (strain K12)
Length
457 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX. It can use NAD or NADP, but NAD is preferred.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
52.729 kDa
Sequence
MSVQQIDWDLALIQKYNYSGPRYTSYPTALEFSEDFGEQAFLQAVARYPERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIVHRAPLFAGRHVSQLHWGGGTPTYLNKAQISRLMKLLRENFQFNADAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHAREIGFTSTNIDLIYGLPKQTPESFAFTLKRVAELNPDRLSVFNYAHLPTIFAAQRKIKDADLPSPQQKLDILQETIAFLTQSGYQFIGMDHFARPDDELAVAQREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDCYAQNQKELKQYYQQVDEQGNALWRGIALTRDDCIRRDVIKSLICNFRLDYAPIEKQWDLHFADYFAEDLKLLAPLAKDGLVDVDEKGIQVTAKGRLLIRNICMCFDTYLRQKARMQQFSRVI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Helicobacter pylori (strain J99 / ATCC 700824)
Length
457 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
53.278 kDa
Sequence
MQTIDFEKFSQYSKPGPRYTSYPTAVEFKENFNEESLKTAFFNHDNLKNPMPLSLYTHLPFCRSACYFCACSVIYTSLEEKKVRYISYLKKELALLKNAMDTNREVAQFHYGGGTPTFFSPPQLDEITQSIQEVFPNFSQDIEMSCEIDPRHFTKEHMQTLFDRGFNRLSFGVQDFDLEVQKAIHRIQPFEMVQESVKLARDYGIKSINFDLIYGLPNQTKEGFLKTLEWVLKLDPDRLAVFNYAHVPWVKKTMRKIDETLLPSPRDKLEILESLISFLEKANYQMIGMDHFAKSDNELYLALQKAELRRNFQGYTTKKFTQTIGIGVTSIGEGSDYYTQNYKDLHYYEKALDLGHLPVERGVALSQEDVLRKEVIMQMMSNLKLDYSKIEEKFSIDFKAHFKKELEKLKPYEEAGLLSFNSKGFEMTRTGGMLVRNMAMEFDAYLRGGEKHFSKTL

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Aquifex aeolicus (strain VF5)
Length
456 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
53.785 kDa
Sequence
MKAEFDKELIKKYDRPGPRYTSYPPATEFTEEVKEDEYVKRLIKSNERKTPLSLYFHIPFCEQRCLYCGCNVIISHRKGIEEPYLERVCREMDLVSQYLDKDRKVIQLHWGGGTPNYLSPEQIKWFMEEIRKRFEFGDNAEISIELDPRYLTDEQIKAIKDAGFNRISLGVQDLDPKVQQAVNRVQPYELIKEKMEKLREAGFESINLDLIYGLPYQTKESFEKTVEKVIELNPDRIATYSFAYIPQVKPHQQLLPKEALPSAEEKLRIFEMVINKFQEAGYVYIGMDHFAKPEDELAVAQRKGELWRNFQGYTTKKGVELLGFGATSIGMLYDSYFQNWKTLRDYNKTVDEGKIPVFRGYVLNEDDFIRREVIMDIMCNLGVEFSKIENMFGINFREYFAKELEELKEMEEDGLIKVEEDRIKIMPVGRLLIRNVAMVFDAHLRRKKELNFSRTI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Length
452 amino acids
Function
Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
49.947 kDa
Sequence
MTNIALLQSLGLFDARVPRYTSYPAAPVFSGAVGADFQAQAIEALDPAVPISVYIHVPFCERLCWFCACRTQGTQTLAPVEAYVGTLLQELELVKKHLPAGVKAGRLHWGGGTPTILSPELIHKLAQAIKAVIPFAEDYEFSVEIDPMMVDEPKIRALSEEGMNRASIGIQDFTDIVQSAIGREQPFENTRACVETLRRYGVHSLNTDLVYGLPHQNRESLAATIDKVLQLGPDRVAIFGYAHVPWMAKRQKLIDENVLPNDMERHELANLAAKMFTEGGFERIGIDHFARPDDSMAVAARSGKLRRNFQGYTDDTCPTLLGIGASSISKFEQGYLQNTAATAAYIKAIEEGRLPGYRGHRMTDEDYLHGRAIEMIMCEFRLDLPALRARFGEAAETMVPRITEAAAKFAPFITVDEAGSMSIEAEGRALTRMIARVFDAYETPEARYSQAS

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Length
452 amino acids
Function
Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
49.947 kDa
Sequence
MTNIALLQSLGLFDARVPRYTSYPAAPVFSGAVGADFQAQAIEALDPAVPISVYIHVPFCERLCWFCACRTQGTQTLAPVEAYVGTLLQELELVKKHLPAGVKAGRLHWGGGTPTILSPELIHKLAQAIKAVIPFAEDYEFSVEIDPMMVDEPKIRALSEEGMNRASIGIQDFTDIVQSAIGREQPFENTRACVETLRRYGVHSLNTDLVYGLPHQNRESLAATIDKVLQLGPDRVAIFGYAHVPWMAKRQKLIDENVLPNDMERHELANLAAKMFTEGGFERIGIDHFARPDDSMAVAARSGKLRRNFQGYTDDTCPTLLGIGASSISKFEQGYLQNTAATAAYIKAIEEGRLPGYRGHRMTDEDYLHGRAIEMIMCEFRLDLPALRARFGEAAETMVPRITEAAAKFAPFITVDEAGSMSIEAEGRALTRMIARVFDAYETPEARYSQAS

Gene
hemN
Protein
Coproporphyrinogen III oxidase, anaerobic 1
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Length
452 amino acids
Function
Anaerobic transformation of coproporphyrinogen III into protoporphyrinogen IX. Dedicated to bacteriochlorophyll biosynthesis.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
50.054 kDa
Sequence
MTNIALLQSLGLFDARVPRYTSYPAAPVFSGAVGADFQAQAIEALDPAVPISVYVHVPFCERLCWFCACRTQGTQTLAPVEAYVGTLLQELELVKQHLPAGVKAGRLHWGGGTPTILSPELIHKLAQAIKAVIPFAEDYEFSVEIDPMMVDEPKIRALSEEGMNRASIGIQDFTDIVQNAIGREQPFENTKACVETLRRYGVHSLNTDLVYGLPHQNRESLAATIDKVLSLRPDRVAIFGYAHVPWMAKRQKLIDETVLPPDIERHELANLAARLFTEGGFERIGIDHFALPDDSMAVAARSRKLRRNFQGYTDDTCPTLLGIGASSISKFEQGYLQNTAATAAYIKSIEEGRLPGYRGHRMTEEDYLHGRAIEMIMCDFFLDLPALRARFGEPAETMVPRIAEAAEKFTPFVTVDADGSMSIAKEGRALARMIARLFDAYETPEARYSQAS

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Paracoccus denitrificans (strain Pd 1222)
Length
451 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
49.848 kDa
Sequence
MEQQSQLERLGLFDARVPRYTSYPTAPHFTPAVGEPVFRDWIAAIPAGAAISLYMHVPFCRRLCWFCACRTQGTQSDEPVRAYAKALLAELDMLKSALAPGVRLSRLHWGGGTPTLMPAEMMRLVAGAVLDAFPLAEGAEFSVEIDPNEIDEARMDALAEAGLNRASIGVQDFDPEIQKIIGREQSFEVTKRAVDMIRDRGIASLNADILYGLPHQDPHRIAESVQKLLALSPDRVALYGYAHVPWMAKRQVMIPSEALPDPHGRLRLFETARELFLADGYDEIGIDHFARPGDGLARAQKAGLLRRNFQGYTDDRAEVLVGLGASSISRFPQGYAQNAPATGAHLARIRDGRFSTTRGHAFSAEDRWRSRMIEALMCDFEIRAEEFIRDHGFDAESLSRILTPVAAHFGDMVDADASGLRITPRGRPLTRMIARMFDGYDMAASGHSAAI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Paracoccus denitrificans (strain Pd 1222)
Length
451 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
49.848 kDa
Sequence
MEQQSQLERLGLFDARVPRYTSYPTAPHFTPAVGEPVFRDWIAAIPAGAAISLYMHVPFCRRLCWFCACRTQGTQSDEPVRAYAKALLAELDMLKSALAPGVRLSRLHWGGGTPTLMPAEMMRLVAGAVLDAFPLAEGAEFSVEIDPNEIDEARMDALAEAGLNRASIGVQDFDPEIQKIIGREQSFEVTKRAVDMIRDRGIASLNADILYGLPHQDPHRIAESVQKLLALSPDRVALYGYAHVPWMAKRQVMIPSEALPDPHGRLRLFETARELFLADGYDEIGIDHFARPGDGLARAQKAGLLRRNFQGYTDDRAEVLVGLGASSISRFPQGYAQNAPATGAHLARIRDGRFSTTRGHAFSAEDRWRSRMIEALMCDFEIRAEEFIRDHGFDAESLSRILTPVAAHFGDMVDADASGLRITPRGRPLTRMIARMFDGYDMAASGHSAAI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Length
450 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
49.327 kDa
Sequence
MRADLAVSYGEERLPRYTSYPTAPHFSPVIDAGTYARWLSELPAGASASLYLHVPFCREMCWYCGCHTQIVRRDDLIAAYQRTLRSEIALVAETIGRRIKVEHIHFGGGTPTIMAPEAFAELMAAMRQAFFVLPSAEIAVEIDPRTLTADMVEAMRLSGVNRASLGVQSFDPIVQRAINRIQSFEQTAAVVDMLRHAGIAGINFDLIYGLPHQTVASCLDTVRRSLLLAPDRFSVFGYAHVPDFKKHQRMINQGALPDGPARHDQACAIANALKEAGYVQIGLDHFARPDDSMAVAFEERTLRRNFQGYTTDQGEVLLGFGASAIGHLPQGYVQNEVQIGAYAQSIGASRLATAKGYGLTDDDRLRADIIERIMCEFSADLGDICARHGAEPEAMLKSASRLKPLISDGVVRLDGDRLAVANDSRFLVRSVAAAFDAHLDPGKQLHSRAV

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Thermosynechococcus vulcanus
Length
325 amino acids
Function
Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
36.817 kDa
Fragment
single
Sequence
AFLMTKDAEISIEVSPRYINGDYFLRGRKLGFNRISFGVQDFDPQVQLAVNRVQRETMFFQVMEWIRAAEFESVNIDLIYGLPYQTVQSFEATIAKTLRLDPDRIAVFNFAYLPNLKPIQKRIDPTTLPDSATKLTILQRVIERLTSQGYRYIGMDHFAKPTDELAIAQRSGDLKRNFQGYTTLPTADLIGFGLTSISMLQAAYAQNQKHLATYFSDVAAGHHGPQECGFNCTVEDLLRRTIIMELMCQFSLDKGAIARQFNLDFDAYFASELAALRELAADGLLHLGRDRLEVTPVGRLLIRNITAVFDAYLQQKSGRTFSKAI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Thermosynechococcus vulcanus
Length
325 amino acids
Function
Involved in the heme and chlorophyll biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
36.817 kDa
Fragment
single
Sequence
AFLMTKDAEISIEVSPRYINGDYFLRGRKLGFNRISFGVQDFDPQVQLAVNRVQRETMFFQVMEWIRAAEFESVNIDLIYGLPYQTVQSFEATIAKTLRLDPDRIAVFNFAYLPNLKPIQKRIDPTTLPDSATKLTILQRVIERLTSQGYRYIGMDHFAKPTDELAIAQRSGDLKRNFQGYTTLPTADLIGFGLTSISMLQAAYAQNQKHLATYFSDVAAGHHGPQECGFNCTVEDLLRRTIIMELMCQFSLDKGAIARQFNLDFDAYFASELAALRELAADGLLHLGRDRLEVTPVGRLLIRNITAVFDAYLQQKSGRTFSKAI

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Mannheimia haemolytica
Length
146 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
17.351 kDa
Fragment
single
Sequence
MSEIIWDLALIQKYNHSGPRYTSYPTALEFNENYTNEDFIRAAARYPERPLSLYVHIPFCHKLCYFCGCNKVITRHRHKVEIYLDYLEREIKTRAPLFQNRLVTQIHWGRGTPTYLDEDQSARLMQMLRANFDVSDDAEISIEMDP

Gene
hemN
Protein
Oxygen-independent coproporphyrinogen III oxidase
Organism
Mannheimia haemolytica
Length
146 amino acids
Function
Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Similarity
Belongs to the anaerobic coproporphyrinogen-III oxidase family.
Mass
17.351 kDa
Fragment
single
Sequence
MSEIIWDLALIQKYNHSGPRYTSYPTALEFNENYTNEDFIRAAARYPERPLSLYVHIPFCHKLCYFCGCNKVITRHRHKVEIYLDYLEREIKTRAPLFQNRLVTQIHWGRGTPTYLDEDQSARLMQMLRANFDVSDDAEISIEMDP